Results 91 to 100 of about 494,249 (301)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Measures that can be used to teach critical thinking skills in nurse prescribers [PDF]

, 2006
Critical thinking is a pervasive skill that involves scrutinizing, differentiating, and appraising information and reflecting on the information gained in order to make judgements and inform clinical decisions. Studies inform us of the need for agreement
Adams, Banning, Banning, Bethune, Biggs, Boychuk Duchscher, Boychuk Duchscher, Brookfield, Clarke, Daly, Daly, Department of Health, Devitt, Elliott, Facione, Fraser, Gendrop, Gilmartin, Girot, Girot, Haith-Cooper, Ip, Irvine, Jones, Kawashima, Koch, Lee, Liimatainen, Loving, Maggi Banning, Marton, O’Neill, Pond, Ribbons, Seymour, Simpson, White, Wong   +37 more
core   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Exploring Differences in Clinical Decisions Between Medical Students and Expert Clinicians

Advances in Medical Education and Practice
Marcos Rojas,1,* Argenta Price,2,* Candice Jeehae Kim,1,3 Sharon F Chen,3 Kathleen Gutierrez,3 Carl Wieman,1,4 Shima Salehi1 1Graduate School of Education, Stanford University, Stanford, California, USA; 2Doerr School of Sustainability, Stanford ...
Rojas M, Price A, Kim CJ, Chen SF, Gutierrez K, Wieman C, Salehi S   +6 more
doaj  

Exploring the perception of pre-clinical and clinical educators on clinical reasoning: A qualitative study.

PLoS ONE
IntroductionEducators have differing perception on the definition and conceptualization of clinical reasoning. Even though clinical reasoning is important in making a sound diagnosis and reducing diagnostic error, educators proved to be a barrier in ...
Siti Norashikin Mohd Tambeh, Farah Dayana Zahedi, Mohamad Nurman Yaman   +2 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Developing clinical reasoning along the cognitive continuum: a mixed methods evaluation of a novel Clinical Diagnosis Assessment

BMC Medical Education
Background Clinical reasoning is a professional capability required for clinical practice. In preclinical training, clinical reasoning is often taught implicitly, and feedback is focused on discrete outcomes of decision-making.
Lucinda E. Ainge, Amanda K. Edgar, Jacqueline M. Kirkman, James A. Armitage   +3 more
doaj   +1 more source

10 tips for clinical educators in designing and delivering learning experiences to improve clinical reasoning for medical students. [version 4; peer review: 2 approved]

MedEdPublish
Background Clinical reasoning processes involve gathering and interpreting information, creating differential diagnoses and testing hypotheses to inform and guide patient management.
Charlotte Deng, Kelvin Le, Khang Duy Ricky Le   +2 more
doaj   +1 more source

Perceptions from Graduates of Professional Athletic Training Programs Involved in Peer-Assisted Learning

, 2014
Context: Research has not explored how peer-assisted learning (PAL) impacts graduates once they are practicing as athletic trainers. Peer-assisted learning has been used in a variety of health education settings but there is a lack of data on its effects
Bates, Dana K.
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source