Results 71 to 80 of about 5,880,836 (301)
FEBS Letters, EarlyView.Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
wiley +1 more source
Validating clinical reasoning: A question of perspective, but whose perspective?
, 2003 This paper explores the notion of validity from different perspectives and addresses its integration with clinical reasoning. Whilst valuing the evidence-based practice (EBP) perspective in our quest for validation of practice, the authors posit that ...
Hunter, D. G., Downing, Angela
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BMC Medical Education, 2020 Background Several instruments intend to measure clinical reasoning capability, yet we lack evidence contextualizing their scores. The authors compared three clinical reasoning instruments [Clinical Reasoning Task (CRT), Patient Note Scoring rubric (PNS),
Yvonne Covin +4 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
Speech-language pathology students : learning clinical reasoning
, 2019 In the last edition of this book, our colleagues Lindy McAllister and Miranda Rose (2008) suggested there was confusion in terminology use between ‘clinical decision making’ and ‘clinical reasoning’.
Johnson, Robyn B. +2 more
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PLoS ONEIntroductionEducators have differing perception on the definition and conceptualization of clinical reasoning. Even though clinical reasoning is important in making a sound diagnosis and reducing diagnostic error, educators proved to be a barrier in ...
Siti Norashikin Mohd Tambeh +2 more
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From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
The inseparability of context and clinical reasoning. [PDF]
Early descriptions of clinical reasoning have described a dual process model that relies on analytical or nonanalytical approaches to develop a working diagnosis. In this classic research, clinical reasoning is portrayed as an individual-driven cognitive
Yang, Qian +6 more
core +2 more sources
Exploring Differences in Clinical Decisions Between Medical Students and Expert Clinicians
Advances in Medical Education and PracticeMarcos Rojas,1,* Argenta Price,2,* Candice Jeehae Kim,1,3 Sharon F Chen,3 Kathleen Gutierrez,3 Carl Wieman,1,4 Shima Salehi1 1Graduate School of Education, Stanford University, Stanford, California, USA; 2Doerr School of Sustainability, Stanford ...
Rojas M +6 more
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