Results 121 to 130 of about 2,866,404 (318)

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Anti-HIV activity in traditional Chinese medicine: clinical implications of monomeric herbal remedies and compound decoctions

Frontiers in Medicine
With the global spread of human immunodeficiency virus (HIV) infection and acquired immune deficiency syndrome (AIDS), the pursuit of potent treatments has ascended as a paramount concern in global healthcare.
Nannan Zhang, Mengyuan Wang, Mengyuan Wang, Ling Gao, Congying Zhang, Xiaoguang Tang, Xianjun Liu, Chunying Bai   +7 more
doaj   +1 more source

Estimation of Clinical Significance: A Brief Note

, 1980
An unwarranted assumption in clinical psychology is to equate the concepts of clinical significance and statistical significance. The intent of this brief note is to present an equation to evaluate the clinical significance of a test measure when the ...
A. Mac Neill Horton
core   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Clinical significance of metallothioneins in cell therapy and nanomedicine

, 2013
Sushil Sharma,1 Afsha Rais,1 Ranbir Sandhu,1 Wynand Nel,1 Manuchair Ebadi21Saint James School of Medicine, Bonaire, The Netherlands; 2Department of Pharmacology, Physiology, and Therapeutics, Center of Excellence in Neuroscience, University of North ...
Sharma S, Sandhu R, Nel W, Ebadi M, Rais A   +4 more
core  

Clinical significance analysis of metaphonological performance and reading in school children with mixed dyslexia after intervention: Case study

, 2020
Investigation Learning Disabilities Laboratory (LIDA) Department of Speech and Hearing Sciences São Paulo State University Júlio de Mesquita Filho (UNESP)Investigation Learning Disabilities Laboratory (LIDA) Department of Speech and Hearing Sciences São ...
dos Santos Liporaci, Gabriela Franco [UNESP], Capellini, Simone Aparecida [UNESP]   +1 more
core  

Clinical significance of serum macrophage migration inhibitory factor (MIF) level in breast cancer.

, 2014
50th Annual Meeting of the American-Society-of-Clinical-Oncology -- MAY 30-JUN 03, 2014 -- Chicago, IL[Abstract Not Available]Amer Soc Clin ...
Tas, Faruk, Karabulut, Senem, Tastekin, Didem, Ciftci, Rumeysa, Sen, Fatma, Aksit, Ece, Vatansever, Sezai   +6 more
core   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

A comparison of clinical paediatric murmur assessment with echocardiography [PDF]

, 2004
Objective: To compare the clinical acumen of paediatric cardiovascular examination between various hospital paediatrician grades. Design: Prospective data collection of clinical and echocardiography findings on paediatric echocardiography referrals ...
Bailey, Mark, Mercieca, Victor, Spiteri, Amaris, Torpiano, John G., Grech, Victor E.   +4 more
core  

Validity and clinical significance of biomechanical testing of implant/bone interface

, 2006
Purpose: The aim of this paper was to review the clinical literature on the Resonance frequency analysis (RFA) and Periotest techniques in order to assess the validity and prognostic value of each technique to detect implants at risk for failure ...
Aparicio, C, Rangert, B, Lang, Niklaus P, Niklaus P. Lang, Bo Rangert, Rangert, Bo, Lang, NP, Carlos Aparicio, Aparicio, Carlos   +8 more
core   +1 more source