Results 111 to 120 of about 2,866,404 (318)

Global emergence of double and multi-carbapenemase producing organisms: epidemiology, clinical significance, and evolutionary benefits on antimicrobial resistance and virulence

Microbiology Spectrum
Redundant carbapenemase-producing (RCP) bacteria, which carry double or multiple carbapenemases, represent a new and concerning phenomenon. The objective of this study is to conduct a comprehensive analysis of the epidemiology and genetic mechanisms of ...
Pei-Bo Yuan, Li-Ting Dai, Qi-Ke Zhang, Yu-Xia Zhong, Wan-Ting Liu, Ling Yang, Ding-Qiang Chen   +6 more
doaj   +1 more source

Clinical Significance of FcγRIIIa Polymorphism in Idiopathic Thrombocytopenic Purpura

, 2006
Purpose: The FcγRIIIa receptor, one of the low-affinity immunoglobulin (Ig) receptors, plays an important role in the clearance of autoantibody-sensitized platelets, which is one of the major pathogenetic mechanisms of idiopathic thrombocytopenic purpura
유철주
core  

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

The mechanism of lncRNA PVT1 in oral squamous cell carcinoma

Frontiers in Oncology
Oral squamous cell carcinoma, a common malignancy of the head and neck, is characterized by high rates of recurrence, metastasis, and chemoresistance, contributing to its persistently low five-year survival rate.
Qunli Ren, Qunli Ren, Qunli Ren, Xiaolan Li, Xiaolan Li, Xiaolan Li, Yuxiang Li, Xiangye Hu, Kangyi Liu, Sheng Tang, Zihan Zhang, Zhihui Wen, Miao Wang, Miao Wang, Miao Wang, Qian Wang, Qian Wang, Qian Wang, Jianguo Liu, Jianguo Liu, Bin Chen, Bin Chen, Bin Chen   +22 more
doaj   +1 more source

Clinical Significance of Serum Bile Acid Profiles in Fatty Liver

Hao-Yue Sun,1 Le-Can Wu,1 Meng-Jie Xu,2 En-Dian Zheng,1 Ying-Cong Yu,1 Yi Ye1 1Department of Gastroenterology, The Wenzhou Third Clinical Institute Affiliated to Wenzhou Medical University, Wenzhou People’s Hospital, The Third Affiliated Hospital of ...
Sun HY, Yu YC, Wu LC, Zheng ED, Ye Y, Xu MJ   +5 more
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Molecular epidemiology and clinical significance of Corynebacterium striatum isolated from clinical specimens

, 2019
Jin Woong Suh,1 Yongguk Ju,2 Chang Kyu Lee,3 Jang Wook Sohn,1,2 Min Ja Kim,1,2 Young Kyung Yoon1,2 1Division of Infectious Diseases, Department of Internal Medicine, Korea University College of Medicine, Seoul, Republic of Korea; 2Institute of Emerging ...
Sohn JW, Lee CK, Suh JW, Ju Y, Kim MJ, Yoon YK   +5 more
core  

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Prevalence, clinical significance, and management of peripheral arterial disease in women: is there a role for postmenopausal hormone therapy?

, 2005
Ramesh Mazhari, Judith HsiaDivision of Cardiology, George Washington University, Washington, DC, USAAbstract: Peripheral arterial disease (PAD), like coronary heart disease, is a clinical manifestation of atherosclerosis and is associated with increased ...
Hsia, J., Mazhari, R., Judith Hsia, Ramesh Mazhari   +3 more
core  

Distinguishing between statistical significance and practical/clinical meaningfulness using statistical inference.

, 2014
Decisions about support for predictions of theories in light of data are made using statistical inference. The dominant approach in sport and exercise science is the Neyman-Pearson significance-testing approach.
Wilkinson, Mick
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source