Results 131 to 140 of about 9,750,898 (317)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

The clinical significance of hypoalbuminaemia

Clinical Nutrition
Albumin is a relatively small molecule with a radius of 7.5 nm and a molecular weight of 65 kDa. It is the most abundant protein in plasma, accounting for 60-75% of its oncotic pressure. Its concentration in plasma is merely one static measurement reflecting a dynamic and complex system of albumin physiology, and is the net result of several different ...
Simon P. Allison, Dileep N. Lobo
openaire   +2 more sources

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Clinical Significance of FcγRIIIa Polymorphism in Idiopathic Thrombocytopenic Purpura

, 2006
Purpose: The FcγRIIIa receptor, one of the low-affinity immunoglobulin (Ig) receptors, plays an important role in the clearance of autoantibody-sensitized platelets, which is one of the major pathogenetic mechanisms of idiopathic thrombocytopenic purpura
유철주
core  

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Tumor-infiltrating immune cells state-implications for various breast cancer subtypes

Frontiers in Immunology
Breast cancer presents a variety of subtypes due to its cellular and molecular heterogeneity. The capacity of cancer cells to proliferate, invade, and metastasize depends not only on their intrinsic characters but also on their dynamic interaction with ...
Tianshuang Xu, Hongjun Zhang, Burton B. Yang, Javeria Qadir, Hui Yuan, Ting Ye   +5 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Prognostic role and clinical significance of trophoblast cell surface antigen 2 in various carcinomas

, 2017
Peng Xu,* Yang Zhao,* Kang Liu,* Shuai Lin, Xinghan Liu, Meng Wang, Pengtao Yang, Tian Tian, Yu-yao Zhu, Zhijun Dai Department of Oncology, The Second Affiliated Hospital, Xi’an Jiaotong University, Xi ...
Liu X, Wang M, Liu K, Xu P, Lin S, Zhu Y, Yang P, Tian T, Dai Z, Zhao Y   +9 more
core  

Clinical significance analysis of metaphonological performance and reading in school children with mixed dyslexia after intervention: Case study

, 2020
Investigation Learning Disabilities Laboratory (LIDA) Department of Speech and Hearing Sciences São Paulo State University Júlio de Mesquita Filho (UNESP)Investigation Learning Disabilities Laboratory (LIDA) Department of Speech and Hearing Sciences São ...
dos Santos Liporaci, Gabriela Franco [UNESP], Capellini, Simone Aparecida [UNESP]   +1 more
core