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Statistical Significance Versus Clinical Significance

Seminars in Cardiothoracic and Vascular Anesthesia, 2008
Unfortunately, the data were statistically nonsignificant due to insufficient power and poor experimental design. Conversely, many large clinical trials obtain a high level of statistical significance with miniscule differences between groups, which are completely clinically irrelevant. However, with proper marketing, billions can be made from results
Timothy T, Houle, David A, Stump
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Coccidioidouria: Clinical Significance

Annals of Internal Medicine, 1976
Twelve patients had urine cultures positive for Coccidioides immitis. Ten patients showed the usual criteria for dissemination, but 2 were believed, before urine culture, to have only chronic pulmonary involvement. In 8 patients, there was impairment of host defense mechanisms due either to associated disease or immunosuppressive drug therapy.
E A, Petersen   +3 more
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Clinically significant myocardial bridging

Heart, 2023
Myocardial bridging is a common anatomical variant in which a major epicardial coronary artery takes an intramyocardial course, leading to dynamic systolic compression. Because coronary perfusion occurs primarily during diastole, most patients with this anatomical variant have no associated perfusion abnormalities or symptoms.
Barbara A Danek   +2 more
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Leukotrienes: Clinical significance

Journal of the American Academy of Dermatology, 1984
The leukotrienes, so named because of their initial identification in leukocyte preparations and the presence of three conjugated double bonds (a conjugated triene), are metabolites of the same polyunsaturated fatty acids (e.g., arachidonic acid) that give rise to the prostaglandins, thromboxanes, and several other families of biologically active ...
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Clinical Significance

2006
Abstract This chapter draws upon the cases of selected individual patients, mostly from personal clinical experience, to focus on the apparent wider clinical relevance of white matter anatomy and disorders. It discusses diseases of the white matter that cause dementia, selected examples of focal white matter lesions that produce ...
Jeremy D. Schmahmann, Deepak N. Pandya
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Measures of Clinical Significance

Journal of the American Academy of Child & Adolescent Psychiatry, 2003
Behavioral scientists are interested in answering three basic questions when examining the relationships between variables (Kirk, 2001). First, is an observed result real or should it be attributed to chance (i.e., statistical significance)? Second, if the result is real, how large is it (i.e., effect size)?
Helena Chmura, Kraemer   +5 more
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Clinical Significance of Hypertriglyceridemia

Seminars in Thrombosis and Hemostasis, 1988
Available data suggest that elevated triglyceride levels in plasma, associated with increased VLDL or chylomicron remnants, are associated with premature coronary artery atherosclerosis. Whether this is a direct effect or as a result of the association of hypertriglyceridemia with decreased HDL as well as decreased LDL particle size remains to be ...
E J, Schaefer   +3 more
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Clinical significance.

Journal of Consulting and Clinical Psychology, 1999
This article initiates the special section on clinical significance. Within a brief précis and overview, the 4 methodological articles and the integrative commentary of the special section are introduced. A call for the inclusion of the assessment of clinical significance in treatment evaluations is extended.
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