Results 91 to 100 of about 12,286,608 (353)

Profiling risk factors for chronic uveitis in juvenile idiopathic arthritis: a new model for EHR-based research. [PDF]

, 2013
BackgroundJuvenile idiopathic arthritis is the most common rheumatic disease in children. Chronic uveitis is a common and serious comorbid condition of juvenile idiopathic arthritis, with insidious presentation and potential to cause blindness. Knowledge
Bauer-Mehren, Anna, Cole, Tyler S, Frankovich, Jennifer, Iyer, Srinivasan, Lependu, Paea, Shah, Nigam H   +5 more
core   +3 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Modulating Placebo Effects in Clinical Trials: Study Team Briefing to Optimize Drug–Placebo Differences

Clinical and Translational Science
Clinical trials often face challenges with placebo effects that can mask actual drug effects. We evaluated whether briefing the study team members on placebo mechanisms influenced analgesia.
Martin Coenen, Ulrike Bingel, Maria Soledad Berdaguer, Christine Fuhrmann, Robert Németh, Jens Rengelshausen, Gunther Hartmann, Christoph Coch, Manfred Schedlowski   +8 more
doaj   +1 more source

Study of Thirteen Causal Genes in Turkish Patients with Clinically Suspected Maturity-Onset Diabetes of the Young (MODY) using a Targeted Next-Generation Sequencing Panel [PDF]

, 2021
Mustafa Doğan, Recep Eröz, Semih Bolu, Hüseyin Yüce, Alper Gezdirici, İlknur Arslanoğlu, Kerem Teralı   +6 more
openalex   +1 more source

Using mobile technology to engage sexual and gender minorities in clinical research. [PDF]

, 2019
IntroductionHistorical and current stigmatizing and discriminatory experiences drive sexual and gender minority (SGM) people away from health care and clinical research.
Bibbins-Domingo, Kirsten, Capriotti, Matthew R, Flentje, Annesa, Frazier, Jeffrey, Lunn, Mitchell R, Obedin-Maliver, Juno, Pletcher, Mark J, Sooksaman, Chollada, Triano, Antony J   +8 more
core   +2 more sources

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Emotive responses to ethical challenges in caring:A Malawi perspective [PDF]

, 2014
This article reports findings of a hermeneutic phenomenological study that explored the clinical learning experience for Malawian undergraduate student nurses.
Baines C, Cerbone DR, Colaizzi PF., Fineman S, Gadamer HG, Graham H, Grigulis A, Heidegger M, Hochschild AR, Maben J, Mangham L., Maslach C, Msiska G., Muula AS, Muula AS, Richards L   +15 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Nanoparticles in preventing biofilm formation on orthodontic brackets: Clinical study

Journal of Pharmacy and Bioallied Sciences
This study investigates the effectiveness of nanoparticles in preventing the formation of biofilms on orthodontic brackets. Biofilm formation is a common concern during orthodontic treatment, as it can lead to oral health issues.
Mohammad K Alam, Shahad R F. Alruwaili, Razan A I. Alderaan, Dana S A. Alanazi   +3 more
doaj   +1 more source

An Ontology to Bridge the Clinical Management of Patients and Public Health Responses for Strengthening Infectious Disease Surveillance: Design Science Study (Preprint)

, 2023
Sachiko Lim, Paul Johannesson
openalex   +1 more source