Results 61 to 70 of about 12,182,221 (303)

Functional MRI Studies in Friedreich's Ataxia: A Systematic Review

Frontiers in Neurology, 2022
Friedreich's ataxia (FRDA) is an inherited neurodegenerative movement disorder with early onset, widespread cerebral and cerebellar pathology, and no cure still available. Functional MRI (fMRI) studies, although currently limited in number, have provided
Marinela Vavla, Filippo Arrigoni, Denis Peruzzo, Domenico Montanaro, Domenico Montanaro, Francesca Frijia, Silvia Pizzighello, Alberto De Luca, Emma Della Libera, Federica Tessarotto, Paola Guerra, Ian H. Harding, Andrea Martinuzzi   +12 more
doaj   +1 more source

Butorphanol for Post-Operative Analgesia - A Comparative Clinical Study with Ketorolac [PDF]

, 2010
Introduction: Butorphanol, an opioid derivative has been shown to have, in addition to its analgesic properties, several other advantageous effects like antistressor, sedative and anti-shivering action.
Adappa, Karunakara, Kadam, Dinesh, Kadri, Rajani, Koteshwar, Reshma, Mohan, Prashanth, Shenoy, Sunil P, Tantry, Thrivikrama Padur, Vastrad, Nandish S   +7 more
core   +1 more source

Cluster headache in Greece: an observational clinical and demographic study of 302 patients. [PDF]

, 2016
BackgroundCluster headache (CH) is considered the most excruciating primary headache syndrome; although much less prevalent than migraine, it is not rare as it affects more than 1/1000 people.
Rapoport, Alan M, Vikelis, Michail
core   +1 more source

Adherence to Protocol Recommendations for Children With Wilms Tumour in Two Consecutive Studies in the United Kingdom and Ireland—Does Variation Matter?

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background and Aims Wilms tumour (WT) has excellent event‐free and overall survival (OS). However, small differences exist between countries participating in the same international study. This led us to examine variation in adherence to protocol recommendations as a potential contributing factor.
Suzanne Tugnait, R. Al‐Saadi, A. Lopez‐Cortes, K. Dzhuma, M. Oostveen, J. Brok, S. Irtan, M. Weeks, J. Bate, S. Baker, R. Williams, M. Powis, D. Saunders, O. Olsen, T. Watson, S. Shelmerdine, S. Vaidya, L. Howell, C. Duncan, G. M. Vujanic, C. Stiller, G. P. Balchin, T. Chowdhury, K. Pritchard‐Jones   +23 more
wiley   +1 more source

Sirolimus for Extracranial Arteriovenous Malformations: A Scoping Review of the Evidence in Syndromic and Non‐Syndromic Cases

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Arteriovenous malformations (AVMs) are rare, high‐flow, vascular anomalies that can occur either sporadically or as part of a genetic syndrome. AVMs can progress with serious morbidity and even mortality if left unchecked. Sirolimus is an mTOR inhibitor that is effective in low‐flow vascular malformations; however, its role in AVMs is unclear.
Will Swansson, Ingrid Winship, Gary Hammerschlag, Laura Scardamaglia   +3 more
wiley   +1 more source

Clinical leadership in service redesign using Clinical Commissioning Groups: a mixed-methods study [PDF]

, 2018
Background: A core component of the Health and Social Care Act 2012 (Great Britain. Health and Social Care Act 2012. London: HMSO; 2012) was the idea of devolving to general practitioners (GPs) a health service leadership role for service redesign.
Abbott, Aveling, Battilana, Bourgeault, British Medical Association, Care Quality Commission, Checkland, Cloutier, Coombs, Currie, Currie, Cyert, Darzi, Denis, Denis, Denis, Dent, Department of Health, Dickinson, DiMaggio, Edwards, Eisenhardt, Eisenhardt, Field, Fitzgerald, Francis, Glaser, Great Britain, Great Britain, Greenhalgh, Greenwood, Greenwood, Gronn, Guthrie, Guthrie, Ham, Hartley, Heifetz, Heifetz, Heracleous, Ibarra, Imison, Ipsos, Kellog, Klein, Lawrence, Lawrence, Lawrence, Le Grand, Lincoln, Mays, McNulty, Miles, Miller, Moon, National Improvement and Leadership Development Board, Newman, NHS Confederation, NHS England, NHS England, NHS England, NHS England, NHS England, NHS England, NHS England and NHS Improvement, Packwood, PricewaterhouseCoopers, Radnor, Reay, Robertson, Robertson, Saks, Sanders, Seo, Sharpe, Sheaff, Smith, Spillane, Spurgeon, Storey, Storey, Storey, Storey, Storey, The Academy of Medical Sciences, The Health Foundation, The King’s Fund, Thornton, Touati, West, Williams   +90 more
core   +3 more sources

Evaluating the Utility of Paired Tumor and Germline Targeted DNA Sequencing for Pediatric Oncology Patients: A Single Institution Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski, Rebecca Ronsley, Shannon M. Stasi, Jeffrey Stevens, Erin R. Rudzinski, Christina M. Lockwood, Sarah E. S. Leary, Bonnie L. Cole, Michelle A. Ting, Vera Paulson   +9 more
wiley   +1 more source

Emotive responses to ethical challenges in caring:A Malawi perspective [PDF]

, 2014
This article reports findings of a hermeneutic phenomenological study that explored the clinical learning experience for Malawian undergraduate student nurses.
Baines C, Cerbone DR, Colaizzi PF., Fineman S, Gadamer HG, Graham H, Grigulis A, Heidegger M, Hochschild AR, Maben J, Mangham L., Maslach C, Msiska G., Muula AS, Muula AS, Richards L   +15 more
core   +1 more source

Predicting the On-Study Relapse Rate for Multiple Sclerosis Patients in Clinical Trials [PDF]

, 2005
Background: The annual relapse rate has been commonly used as a primary efficacy endpoint in phase III multiple sclerosis (MS) clinical trials. The aim of this study was to determine the relative contribution of different possible prognostic factors ...
Heigenhauser, L., Held, U., Kappos, L., Polman, C., Shang, C.   +4 more
core   +2 more sources

Preferences of Pediatric Patients and Their Caregivers for Chemotherapy‐Induced Nausea and Vomiting Control Endpoints: A Mixed Methods Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Although not always achieved, complete chemotherapy‐induced nausea and vomiting (CINV) control is the conventional goal of CINV prophylaxis. In this two‐center, mixed‐methods study, we sought to understand the preferences of adolescent patients and family caregivers for CINV control endpoints.
Haley Newman, Tadi Hondonga, Alison Berry, Caitlin Elgarten, Jason Freedman, Katelyn Oranges, Sara McDonough, Caroline Diorio, L. Lee Dupuis   +8 more
wiley   +1 more source