Results 101 to 110 of about 3,456,067 (356)

Atom transfer radical polymer-modified paper for improvement in protein fixation in paper-based ELISA

BMC Chemistry, 2019
A newly modified paper-based enzyme-linked immunosorbent assay (P-ELISA) was established by immobilizing more proteins on the paper surface through an atom transfer radical polymerization (ATRP) reaction.
Lu Qi, Aihong Zhang, Yu Wang, Long Liu, Xinghe Wang   +4 more
doaj   +1 more source

Cellular liquid biopsy provides unique chances for disease monitoring, preclinical model generation and therapy adjustment in rare salivary gland cancer patients

Molecular Oncology, EarlyView.
We quantified and cultured circulating tumor cells (CTCs) of 62 patients with various cancer types and generated CTC‐derived tumoroid models from two salivary gland cancer patients. Cellular liquid biopsy‐derived information enabled molecular genetic assessment of systemic disease heterogeneity and functional testing for therapy selection in both ...
Nataša Stojanović Gužvić, Florian Lüke, Steffi Treitschke, Andrea Coluccio, Martin Hoffmann, Giancarlo Feliciello, Adithi Ravikumar Varadarajan, Xin Lu, Kathrin Weidele, Catherine Botteron, Silvia Materna–Reichelt, Felix Keil, Katja Evert, Florian Weber, Thomas Schamberger, Michael Althammer, Jirka Grosse, Dirk Hellwig, Christian Schulz, Stephan Seitz, Peter Ugocsai, Anke Schlenska‐Lange, Roman Mayr, Ulrich Kaiser, Wolfgang Dietmaier, Bernhard Polzer, Jens Warfsmann, Kamran Honarnejad, Tobias Pukrop, Daniel Heudobler, Christoph A. Klein, Christian Werno   +31 more
wiley   +1 more source

Pharmacokinetics and Bioequivalence of Two Formulations of Azithromycin Tablets: A Randomized, Single-Dose, Three-Period, Crossover Study in Healthy Chinese Volunteers Under Fasting and Fed Conditions

Drugs in R&D
Background and Objective Azithromycin is the first azalide antibiotic that is related to the macrolide family of antibiotics. Bioequivalence studies in China are initiated by the National Medical Products Administration (NMPA), which supports a generic ...
Yingrong Chen, Libing Ye, Jue Mei, Mengli Tian, Min Xu, Qiuyue Jin, Xiang Yu, Shuixin Yang, Jie Wang   +8 more
doaj   +1 more source

AAPT Diagnostic Criteria for Chronic Sickle Cell Disease Pain [PDF]

, 2017
Pain in sickle cell disease (SCD) is associated with increased morbidity, mortality, and high health care costs. Although episodic acute pain is the hallmark of this disorder, there is an increasing awareness that chronic pain is part of the pain ...
Aguilar, Ameringer, Ballas, Ballas, Ballas, Barakat, Bediako, Brandow, Brandow, Bruehl, Campbell, Campbell, Carlton Dampier, Carroll, Carroll, Carroll, Crawford, Dampier, Dampier, Dampier, Dampier, Dampier, Dampier, Darbari, Darbari, Darbari, DeBaun, Deepika S. Darbari, Dworkin, Dyson, Edwards, Fillingim, Fillingim, Franck, Gil, Gil, Hassell, Hoff, Houston-Yu, Igbineweka, Jonassaint, Kathryn Hassell, Kato, Kauf, Koshy, Levenson, Lewandowski, Long, Mahadeo, Maixner, Mathur, McClish, Milner, Minniti, Minniti, Myrvik, Niebanck, Palermo, Palermo, Palermo, Paul, Platt, Powars, Raphael, Savitt, Schwartz, Serarslan, Serjeant, Shapiro, Sil, Smith, Smith, Sogutlu, Steinberg, Taylor, Tonya M. Palermo, Tsao, Turk, Valrie, Vance, Vardeh, Walco, Walco, Wallen, Wally Smith, Wilkie, William Zempsky, Wison Schaeffer, Yawn, Zempsky   +89 more
core   +3 more sources

Targeting rapid TKI‐induced AXL upregulation overcomes adaptive ERK reactivation and exerts antileukemic effects in FLT3/ITD acute myeloid leukemia

Molecular Oncology, EarlyView.
Adaptive ERK reactivation hinders FLT3 tyrosine kinase inhibitor (TKI) treatment in FLT3/ITD acute myeloid leukemia. Here, we report that FLT3 TKI treatment rapidly induces AXL expression and upregulation that is temporally associated with the adaptive ERK reactivation.
Tessa S. Seale, Li Li, J. Kyle Bruner, Melody Chou, Bao Nguyen, Jaesung Seo, Ruiqi Zhu, Mark J. Levis, Christine A. Pratilas, Donald Small   +9 more
wiley   +1 more source

Combined spatially resolved metabolomics and spatial transcriptomics reveal the mechanism of RACK1‐mediated fatty acid synthesis

Molecular Oncology, EarlyView.
The authors analyzed the spatial distributions of gene and metabolite profiles in cervical cancer through spatial transcriptomic and spatially resolved metabolomic techniques. Pivotal genes and metabolites within these cases were then identified and validated.
Lixiu Xu, Jinqiu Li, Junqi Ma, Ayshamgul Hasim   +3 more
wiley   +1 more source

Clinical Trials and Clinical Judgment

Journal of the American College of Cardiology, 2008
![Figure][1] Cardiovascular specialists have become justifiably proud of their commitment to evidence-based medicine and clinical trials. More large-scale randomized prospective clinical trials (RCTs) are performed in cardiology than in any other field, and contemporary practice is ...
openaire   +3 more sources

Circulating tumor DNA (ctDNA) trajectories predict survival in trifluridine/tipiracil‐treated metastatic colorectal cancer patients

Molecular Oncology, EarlyView.
The authors applied joint/mixed models that predict mortality of trifluridine/tipiracil‐treated metastatic colorectal cancer patients based on circulating tumor DNA (ctDNA) trajectories. Patients at high risk of death could be spared aggressive therapy with the prospect of a higher quality of life in their remaining lifetime, whereas patients with a ...
Matthias Unseld, Stefan Kühberger, Ricarda Graf, Christine Beichler, Markus Braun, Nadia Dandachi, Ellen Heitzer, Gerald W. Prager   +7 more
wiley   +1 more source

Trials, Tricks and Transparency: How Disclosure Rules Affect Clinical Knowledge [PDF]

Scandals of selective reporting of clinical trial results by pharmaceutical firms have underlined the need for more transparency in clinical trials. We provide a theoretical framework which reproduces incentives for selective reporting and yields three ...
Matthias Dahm, Nicolás Porteiro, Paula González   +2 more
core  

Integrative systems‐level analysis reveals a contextual crosstalk between hypoxia and global metabolism in human breast tumors

Molecular Oncology, EarlyView.
Breast tumor samples scored for metabolic deregulation (M1 to M3) were given a hypoxia score (HS). The highest HS occurred in patients with strongest metabolic deregulation (M3), supporting tumor aggressiveness. HS correlated with the highest number of metabolic pathways in M1. This suggests hypoxia to be an early event in metabolic deregulation.
Raefa Abou Khouzam, Salem Chouaib, Mohammad Askandar Iqbal   +2 more
wiley   +1 more source