Results 101 to 110 of about 3,600,128 (335)
Molecular Oncology, EarlyView.Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser +11 more
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interAdapt -- An Interactive Tool for Designing and Evaluating Randomized Trials with Adaptive Enrollment Criteria [PDF]
, 2014 The interAdapt R package is designed to be used by statisticians and clinical investigators to plan randomized trials. It can be used to determine if certain adaptive designs offer tangible benefits compared to standard designs, in the context of ...
Fisher, Aaron +2 more
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Molecular Oncology, EarlyView.Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu +11 more
wiley +1 more source
Clinical trials in dermatology
International Journal of Women's Dermatology, 2017 Clinical trials are the backbone of modern day medicine. Randomized, double-blinded, placebo-controlled studies are critical for advancement in medicine and dermatology. Skin conditions such as psoriasis and atopic dermatitis are among the most common health problems in the United States.
Kristin Torre, Mona Shahriari
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LEGAL ASPECTS OF CLINICAL TRIALS INVOLVING UNDER-AGE SUBJECTS IN RUSSIA
Педиатрическая фармакология, 2010 The article focuses on a complicated, no less pressing issue of conducting clinical trials in pediatrics. When vulnerable groups of patients are involved as subjects in clinical trials, specific ethical issues inevitably arise.
S.S. Zavidova, A.A. Tolpanova
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Pediatric InvestigationImportance Pediatric medication is a challenging issue globally. Promoting trials of medications for children and implementing measures to encourage innovation for addressing unmet medical and health needs are important.
Chang Liu +4 more
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Frontiers in PharmacologyBackgroundMefunidone is a novel synthetic compound and is better when compared to pirfenidone for the anti-fibrotic treatment of renal fibrosis in end-stage renal disease.
Mai Han +14 more
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Snapshot: Trial Types in Precision Medicine. [PDF]
, 2020 Integrating precision diagnostics into personalized treatments requires understanding how biomarkers relate to clinical outcomes. Various clinical data collection methods exist, each with strengths and weaknesses. Interventional data are high quality but
Bergan, Raymond +5 more
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Smallpox in Tripolitania, 1946: an epidemiological and clinical study of 500 cases, including trials of penicillin treatment [PDF]
, 1948 C. W. Dixon
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