Results 121 to 130 of about 13,113,839 (405)

Atom transfer radical polymer-modified paper for improvement in protein fixation in paper-based ELISA

BMC Chemistry, 2019
A newly modified paper-based enzyme-linked immunosorbent assay (P-ELISA) was established by immobilizing more proteins on the paper surface through an atom transfer radical polymerization (ATRP) reaction.
Lu Qi, Aihong Zhang, Yu Wang, Long Liu, Xinghe Wang   +4 more
doaj   +1 more source

Clinical Trial Participants’ Views of the Risks and Benefits of Data Sharing

New England Journal of Medicine, 2018
Background Sharing of participant‐level clinical trial data has potential benefits, but concerns about potential harms to research participants have led some pharmaceutical sponsors and investigators to urge caution.
M. Mello, Van Lieou, S. Goodman
semanticscholar   +1 more source

On‐treatment dynamics of circulating extracellular vesicles in the first‐line setting of patients with advanced non‐small cell lung cancer: the LEXOVE prospective study

Molecular Oncology, EarlyView.
The LEXOVE prospective study evaluated plasma cell‐free extracellular vesicle (cfEV) dynamics using Bradford assay and dynamic light scattering in metastatic non‐small cell lung cancer patients undergoing first‐line treatments, correlating a ∆cfEV < 20% with improved median progression‐free survival in responders versus non‐responders.
Valerio Gristina, Viviana Bazan, Nadia Barraco, Simona Taverna, Mauro Manno, Samuele Raccosta, Anna Paola Carreca, Marco Bono, Tancredi Didier Bazan Russo, Francesco Pepe, Pasquale Pisapia, Lorena Incorvaia, Giuseppe Badalamenti, Giancarlo Troncone, Umberto Malapelle, Daniele Santini, Antonio Russo, Antonio Galvano   +17 more
wiley   +1 more source

The Role of Clinical Trial Participation in Cancer Research: Barriers, Evidence, and Strategies.

American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting, 2016
Fewer than one in 20 adult patients with cancer enroll in cancer clinical trials. Although barriers to trial participation have been the subject of frequent study, the rate of trial participation has not changed substantially over time. Barriers to trial
J. Unger, E. Cook, E. Tai, A. Bleyer
semanticscholar   +2 more sources

Study on bioequivalence and influence of obesity-related indicators on pharmacokinetics and pharmacodynamics for insulin degludec in healthy subjects

Scientific Reports
This study aimed to evaluate the bioequivalence between test and reference insulin degludec (IDeg) and the effects of body composition on pharmacokinetics and pharmacodynamics of IDeg in Chinese healthy volunteers.
Rui Su, Lei Wan, Yi Tao, Mingxue Zhu, Junliang Pu, Zhongping Li, Yuan Chen, Chengyong Tang   +7 more
doaj   +1 more source

A phase I, randomized study to evaluate the safety, tolerability, and pharmacokinetics of mefunidone in healthy subjects

Frontiers in Pharmacology
BackgroundMefunidone is a novel synthetic compound and is better when compared to pirfenidone for the anti-fibrotic treatment of renal fibrosis in end-stage renal disease.
Mai Han, Bishan Huo, Gaoyun Hu, Xin Zhang, Gang Cui, Wei Wu, Na Mi, Shixi Zhang, Jiangli Jin, Xing Lu, Bidong Wu, Chunyan Xiao, Jing Wang, Zheng Bian, Jintong Li   +14 more
doaj   +1 more source

A psychological approach to providing self-management education for people with type 2 diabetes : the diabetes manual [PDF]

, 2006
Background: The objectives of this study were twofold (i) to develop the Diabetes Manual, a selfmanagement educational intervention aimed at improving biomedical and psychosocial outcomes (ii) to produce early phase evidence relating to validity and ...
Dale, Jeremy, Docherty, Andrea, Sturt, Jackie, Taylor, Hafrun, Taylor, Louise   +4 more
core   +4 more sources

Clinical Trial Designs

Indian Dermatology Online Journal, 2019
The delivery of an intervention whether drug, a dietary change, a lifestyle change, or a psychological therapy session counts as an intervention and hence must be dealt as a clinical trial [Figure 1].
Brijesh Nair
semanticscholar   +1 more source

Cellular liquid biopsy provides unique chances for disease monitoring, preclinical model generation and therapy adjustment in rare salivary gland cancer patients

Molecular Oncology, EarlyView.
We quantified and cultured circulating tumor cells (CTCs) of 62 patients with various cancer types and generated CTC‐derived tumoroid models from two salivary gland cancer patients. Cellular liquid biopsy‐derived information enabled molecular genetic assessment of systemic disease heterogeneity and functional testing for therapy selection in both ...
Nataša Stojanović Gužvić, Florian Lüke, Steffi Treitschke, Andrea Coluccio, Martin Hoffmann, Giancarlo Feliciello, Adithi Ravikumar Varadarajan, Xin Lu, Kathrin Weidele, Catherine Botteron, Silvia Materna–Reichelt, Felix Keil, Katja Evert, Florian Weber, Thomas Schamberger, Michael Althammer, Jirka Grosse, Dirk Hellwig, Christian Schulz, Stephan Seitz, Peter Ugocsai, Anke Schlenska‐Lange, Roman Mayr, Ulrich Kaiser, Wolfgang Dietmaier, Bernhard Polzer, Jens Warfsmann, Kamran Honarnejad, Tobias Pukrop, Daniel Heudobler, Christoph A. Klein, Christian Werno   +31 more
wiley   +1 more source

AAPT Diagnostic Criteria for Chronic Sickle Cell Disease Pain [PDF]

, 2017
Pain in sickle cell disease (SCD) is associated with increased morbidity, mortality, and high health care costs. Although episodic acute pain is the hallmark of this disorder, there is an increasing awareness that chronic pain is part of the pain ...
Aguilar, Ameringer, Ballas, Ballas, Ballas, Barakat, Bediako, Brandow, Brandow, Bruehl, Campbell, Campbell, Carlton Dampier, Carroll, Carroll, Carroll, Crawford, Dampier, Dampier, Dampier, Dampier, Dampier, Dampier, Darbari, Darbari, Darbari, DeBaun, Deepika S. Darbari, Dworkin, Dyson, Edwards, Fillingim, Fillingim, Franck, Gil, Gil, Hassell, Hoff, Houston-Yu, Igbineweka, Jonassaint, Kathryn Hassell, Kato, Kauf, Koshy, Levenson, Lewandowski, Long, Mahadeo, Maixner, Mathur, McClish, Milner, Minniti, Minniti, Myrvik, Niebanck, Palermo, Palermo, Palermo, Paul, Platt, Powars, Raphael, Savitt, Schwartz, Serarslan, Serjeant, Shapiro, Sil, Smith, Smith, Sogutlu, Steinberg, Taylor, Tonya M. Palermo, Tsao, Turk, Valrie, Vance, Vardeh, Walco, Walco, Wallen, Wally Smith, Wilkie, William Zempsky, Wison Schaeffer, Yawn, Zempsky   +89 more
core   +3 more sources