Results 61 to 70 of about 3,600,128 (335)

Single‐cell insights into the role of T cells in B‐cell malignancies

FEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source

Active Clinical Trials for Personalized Medicine

, 2015
Individualized treatment rules (ITRs) tailor treatments according to individual patient characteristics. They can significantly improve patient care and are thus becoming increasingly popular.
Cheng, Guang, Minsker, Stanislav, Zhao, Ying-Qi   +2 more
core   +2 more sources

TREC-Rio trial: a randomised controlled trial for rapid tranquillisation for agitated patients in emergency psychiatric rooms [ISRCTN44153243] [PDF]

, 2002
Agitated or violent patients constitute 10% of all emergency psychiatric treatment. Management guidelines, the preferred treatment of clinicians and clinical practice all differ.
A Jablensky, B Thornley, CB Joy, Clive E Adams, E Coutinho, Evandro SF Coutinho, Expert Consensus Guideline Group, F Moritz, G Huf, Gisele Huf, HI Kaplan, J Ludbrook, JG Cunnane, LS Pilowsky, M Fenton, M Hotopf, M Wyant, P Armitage, RL Binder, The Royal College of Psychiatrists, VW Berger, Z Atakan   +21 more
core   +3 more sources

Cyclic nucleotide signaling as a drug target in retinitis pigmentosa

FEBS Letters, EarlyView.
Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää, Ahmed B. Montaser, Henri Leinonen   +2 more
wiley   +1 more source

Persian medicine anti-dandruff topical remedies: a narrative review [PDF]

Journal of Medicinal Plants, 2022
Background: Dandruff is a common and important scalp disorder affecting almost half of the population at the pre-pubertal age. Various studies have shown that using herbs can be a good option for improving dandruff. There is a way to search for effective
Mohsen Naseri, Maryam Iranzadasl, Farzaneh Ghaffari, Vahedeh Naseri, Fatemeh Emadi, Fatemeh Alijaniha, Abdolazim Behfar, Zahra Bahaeddin   +7 more
doaj  

Safety, tolerability, pharmacokinetics and effects of diet on AD16, a novel neuroinflammatory inhibitor for Alzheimer’s disease: a randomized phase 1 study

BMC Medicine, 2023
Background AD16 is a Class 1.1 new drug candidate for Alzheimer’s disease (AD), which has demonstrated potential benefits in AD by reducing neuroinflammation in preclinical studies.
Daizhuang Peng, Sumei Xu, Ting Zou, Yahui Wang, Wenjuan Ouyang, Yalan Zhang, Chengmei Dong, Dai Li, Jie Guo, Qiuying Shen, Xiaolei Hu, Wenzhi Zhou, Xiaomin Li, Qun Qin   +13 more
doaj   +1 more source

Establishing cost-effectiveness of genetic targeting of cancer therapies [PDF]

, 2011
The clinical benefit of a new genomic instrument, the 70-gene signature for breast cancer patients, is being evaluated in a randomised clinical trial. The early, controlled implementation process is supported by a Constructive Technology Assessment to ...
Harten, W.H. van, Joore, M.A., Retèl, Valesca P., Rutgers, E.J.Th.   +3 more
core   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

Polyunsaturated fatty acids in the pathogenesis and treatment of multiple sclerosis [PDF]

, 2007
Epidemiological, biochemical, animal model and clinical trial data described in this overview strongly suggest that polyunsaturated fatty acids, particularly n-6 fatty acids, have a role in the pathogenesis and treatment of multiple sclerosis (MS).
Copeland, Esparza, Fitzgerald, Harbige, Harbige, Jones, Karpus, Laurence S. Harbige, Mohammad K. Sharief, Mokhtarian, Ovadia, Santambrogio, Selmaj, Serafina, Thompson, Thompson, Vartanian   +16 more
core   +2 more sources

Goodbye flat lymphoma biology

FEBS Letters, EarlyView.
Three‐dimensional (3D) biological systems have become key tools in lymphoma research, offering reliable in vitro and ex vivo platforms to explore pathogenesis and support precision medicine. This review highlights current 3D non‐Hodgkin lymphoma models, detailing their features, advantages, and limitations, and provides a broad perspective on future ...
Carla Faria, Cèlia Dobaño‐López, Patricia Pérez‐Galán, Christine Bezombes   +3 more
wiley   +1 more source