Results 91 to 100 of about 608,159 (405)

Which Obstacles Prevent Us from Recruiting into Clinical Trials: A Survey about the Environment for Clinical Studies at a German University Hospital in a Comprehensive Cancer Center

Frontiers in Oncology, 2017
BackgroundProspective clinical studies are the most important tool in modern medicine. The standard in good clinical practice in clinical trials has constantly improved leading to more sophisticated protocols.
Christoph Straube, Christoph Straube, Christoph Straube, Peter Herschbach, Peter Herschbach, Peter Herschbach, Stephanie E. Combs, Stephanie E. Combs, Stephanie E. Combs, Stephanie E. Combs   +9 more
doaj   +1 more source

RAD50 missense variants differentially affect the DNA damage response and mitotic progression

FEBS Letters, EarlyView.
RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker, Swantje Kebel, Lea Völkening, Anna Vatselia, Louisa Weinhold, Girmay Asgedom, Axel Schambach, Detlev Schindler, Thilo Dörk, Kristine Bousset   +9 more
wiley   +1 more source

Can implant surfaces affect implant stability during osseointegration? A randomized clinical trial

Brazilian Oral Research, 2018
This randomized clinical trial evaluated the insertion torque (IT), primary, and secondary stability of dental implants with different surface treatments during the osseointegration period.
Luiz Carlos do CARMO FILHO, Raissa Micaella MARCELLO-MACHADO, Eduardo Dickie de CASTILHOS, Altair Antoninha DEL BEL CURY, Fernanda FAOT   +4 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Hemorrhagic transformation: A review of the rate of hemorrhage in the major clinical trials of acute ischemic stroke

Frontiers in Neurology, 2013
Acute ischemic stroke is a devastating disease that is often complicated by hemorrhagic transformation. While significant advances have been made over the past two decades with regard to emergent treatment of AIS, many of these therapeutic options are ...
Eric S Sussman, Edward Sander Connolly Jr.   +1 more
doaj   +1 more source

Randomized clinical trial of topical mupirocin versus oral erythromycin for impetigo [PDF]

Antimicrobial Agents and Chemotherapy, 1988
The safety and efficacy of a new topical antiinfective agent, mupirocin, was compared with that of oral erythromycin ethylsuccinate in the treatment of impetigo in children. Sixty-two children aged 5 months to 13 years with impetigo were assigned to be treated with either mupirocin in three daily applications or erythromycin ethylsuccinate (40 mg/kg of
J Goldfarb, Jeffrey L. Blumer, E Lemon, D. Crenshaw, J O'Horo   +4 more
openaire   +3 more sources

‘Cloud computing’ and clinical trials: report from an ECRIN workshop

Trials, 2015
Growing use of cloud computing in clinical trials prompted the European Clinical Research Infrastructures Network, a European non-profit organisation established to support multinational clinical research, to organise a one-day workshop on the topic to ...
C. Ohmann, Steve Canham, E. Danielyan, Steve Robertshaw, Y. Legré, L. Clivio, J. Demotes   +6 more
semanticscholar   +1 more source

A study of the perceived risks, benefits and barriers to the use of SDD in adult critical care units (the SuDDICU study) [PDF]

, 2010
Peer reviewedPublisher ...
A Liberati, AB Nathens, AJ Bastin, AM de Smet, BH Cuthbertson, CM Vandenbroucke-Grauls, DK Heyland, FF Sniehotta, I Ajzen, I Seppelt, J Francis, J Francis, J Grimshaw, JC Hurley, JE McKenzie, JJ Francis, K Krippendorff, L MacIntyre, L Silvestri, L Silvestri, M Eccles, MH Kollef, MK Campbell, R D'Amico, R Redman, R Shah, RB Akins, S Hrisos, S Michie, S Michie, S Michie, Selective Decontamination of the Digestive Tract Trialists' Collaborative Group   +31 more
core   +4 more sources

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source

Mapping the evolving definitions of translational research

Journal of Clinical and Translational Science, 2017
Objective Systematic review and analysis of definitions of translational research. Materials and methods The final corpus was comprised of 33 papers, each
Daniel G. Fort, Timothy M. Herr, Pamela L. Shaw, Karen E. Gutzman, Justin B. Starren   +4 more
doaj   +1 more source