Results 91 to 100 of about 1,939,729 (406)

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Non-Inferiority Trials in Surgical Oncology [PDF]

, 2018
The classical randomized controlled clinical trial is designed to prove superiority of an investigational therapy over an established therapy or placebo (here referred to as "superiority trial”).
Adamina, Michel, Fueglistaler, Philipp, Guller, Ulrich   +2 more
core  

The development of QUADAS : a tool for the quality assessment of studies of diagnostic accuracy included in systematic reviews [PDF]

, 2003
BACKGROUND: In the era of evidence based medicine, with systematic reviews as its cornerstone, adequate quality assessment tools should be available.
Anne WS Rutjes, AR Jadad, DL Streiner, J Deeks, Johannes B Reitsma, Jos Kleijnen, KF Schulz, M Kerr, P Bossuyt, P Glasziou, P Juni, P Juni, Patrick MM Bossuyt, Penny Whiting, S Greenland   +14 more
core   +4 more sources

Do health care institutions value research? A mixed methods study of barriers and facilitators to methodological rigor in pediatric randomized trials

BMC Medical Research Methodology, 2012
Background Pediatric randomized controlled trials (RCTs) are susceptible to a high risk of bias. We examined the barriers and facilitators that pediatric trialists face in the design and conduct of unbiased trials. Methods We used a mixed methods design,
Hamm Michele P, Scott Shannon D, Klassen Terry P, Moher David, Hartling Lisa   +4 more
doaj   +1 more source

Predicting the clinical citation count of biomedical papers using multilayer perceptron neural network [PDF]

Journal of Informetrics 2022, 2022
The number of clinical citations received from clinical guidelines or clinical trials has been considered as one of the most appropriate indicators for quantifying the clinical impact of biomedical papers. Therefore, the early prediction of the clinical citation count of biomedical papers is critical to scientific activities in biomedicine, such as ...
arxiv  

The thioredoxin‐like and one glutaredoxin domain are required to rescue the iron‐starvation phenotype of HeLa GLRX3 knock out cells

FEBS Letters, EarlyView.
Glutaredoxin (Grx) 3 proteins contain a thioredoxin domain and one to three class II Grx domains. These proteins play a crucial role in iron homeostasis in eukaryotic cells. In human Grx3, at least one of the two Grx domains, together with the thioredoxin domain, is essential for its function in iron metabolism.
Laura Magdalena Jordt, Manuela Gellert, Finja Zelms, Sander Bekeschus, Christopher Horst Lillig   +4 more
wiley   +1 more source

Optimal search strategies for identifying sound clinical prediction studies in EMBASE [PDF]

, 2005
BACKGROUND: Clinical prediction guides assist clinicians by pointing to specific elements of the patient's clinical presentation that should be considered when forming a diagnosis, prognosis or judgment regarding treatment outcome.
A Laupacis, AG Randolph, AR Jadad, BJ Ingui, BT Walsh, CE Adams, FA McAlister, Jennifer L Holland, JF Steiner, JH Wasson, JI Emparanza, JW Ely, LM Bachmann, LM Bachmann, Nancy L Wilczynski, NL Wilczynski, NL Wilczynski, NL Wilczynski, PS Wells, R Brian Haynes, RB Haynes, RB Haynes, RJ Watson, SS Wong, T McGinn, TG McGinn   +25 more
core   +3 more sources

Evaluation of sodium nitroprusside for controlled hypotension in children during surgery

Frontiers in Pharmacology, 2015
Purpose. (1) To define the onset and offset of the blood-pressure-lowering effects of sodium nitroprusside (SNP) for use in developing instructions for dose titration in children undergoing a surgical or medical procedure, and (2) to assess the safety of
David R Drover, Gregory B Hammer, Jeffrey Scott Barrett, Carol A Cohane, Tammy eReece, Anne eZajicek, Scott eSchulman, Scott eSchulman   +7 more
doaj   +1 more source

Clinical Trial Recommendations Using Semantics-Based Inductive Inference and Knowledge Graph Embeddings [PDF]

arXiv, 2023
Designing a new clinical trial entails many decisions, such as defining a cohort and setting the study objectives to name a few, and therefore can benefit from recommendations based on exhaustive mining of past clinical trial records. Here, we propose a novel recommendation methodology, based on neural embeddings trained on a first-of-a-kind knowledge ...
arxiv  

Subpar reporting of pre‐analytical variables in RNA‐focused blood plasma studies

Molecular Oncology, EarlyView.
Pre‐analytical variables strongly influence the analysis of extracellular RNA (cell‐free RNA; exRNA) derived from blood plasma. Their reporting is essential to allow interpretation and replication of results. By evaluating 200 exRNA studies, we pinpoint a lack of reporting pre‐analytical variables associated with blood collection, plasma preparation ...
Céleste Van Der Schueren, Philippe Decruyenaere, Francisco Avila Cobos, Johanna Bult, Jill Deleu, Laudonia Lidia Dipalo, Hetty Hilde Helsmoortel, Eva Hulstaert, Annelien Morlion, Elena Ramos Varas, Kathleen Schoofs, Wim Trypsteen, Eveline Vanden Eynde, Hanne Van Droogenbroeck, Kimberly Verniers, Jo Vandesompele, Anneleen Decock   +16 more
wiley   +1 more source