Results 91 to 100 of about 624,126 (316)

Single high-dose buprenorphine for opioid craving during withdrawal. [PDF]

, 2018
BackgroundOpioid use disorder is one of the most prevalent addiction problems worldwide. Buprenorphine is used as a medication to treat this disorder, but in countries where buprenorphine is unavailable in combination with naloxone, diversion can be a ...
Ahmadi, Jamshid, Ghahremani, Dara, Jahromi, Mina Sefidfard, London, Edythe D   +3 more
core   +2 more sources

Olive Leaf Extract as a New Topical Management for Oral Mucositis Following Chemotherapy: A Microbiological Examination, Experimental Animal Study and Clinical Trial [PDF]

Pharmaceutica Analytica Acta, 2013
Oral mucositis is a common complication of intensive cancer chemotherapy and radiotherapy. Olive leaf extract was investigated through microbiological, experimental animal studies and clinical trial. The results were compared with the action of benzydamine HCl as positive control and normal saline as negative control.
openaire   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Study Design Characteristics and Pharmacological Mechanisms in International Clinical Trials Registry Platform: Registered Clinical Trials on Antiviral Drugs for COVID-19

Drug Design, Development and Therapy, 2020
Weilong Zhang,1,* Yinghua Lv,1,* Juan Yang,1 Yunhui Chen,2 Yingchun He,1 Jihan Huang1 1Center for Drug Clinical Research, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203 ...
Zhang W, Lv Y, Yang J, Chen Y, He Y, Huang J   +5 more
doaj  

Is it possible to estimate the minimal clinically important treatment effect needed to change practice in preterm birth prevention? Results of an obstetrician survey used to support the design of a trial

BMC Medical Research Methodology, 2012
Background Sample sizes for obstetrical trials are often based on the opinion of investigators about clinically important effect size. We surveyed Canadian obstetricians to investigate clinically important effect sizes required before introducing new ...
Ross Sue, Milne Jill, Dwinnell Shannon, Tang Selphee, Wood Stephen   +4 more
doaj   +1 more source

Choosing and using methodological search filters : searchers' views [PDF]

, 2015
© 2014 The authors.
Beale, Sophie, Boachie, Charles, Duffy, Steven, Fraser, Cynthia, Glanville, Julie, Harbour, Jenny, Lefebvre, Carol, McCool, Rachael, Smith, Lynne, Varley, Danielle, Wright, Dianne   +10 more
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Insights From Pre-Clinical and Clinical Studies on the Role of Innate Inflammation in Atherosclerosis Regression

Frontiers in Cardiovascular Medicine, 2018
Atherosclerosis, the underlying cause of coronary artery (CAD) and other cardiovascular diseases, is initiated by macrophage-mediated immune responses to lipoprotein and cholesterol accumulation in artery walls, which result in the formation of plaques ...
Karishma Rahman, Edward A. Fisher
doaj   +1 more source

Chloroprocaine 3% Gel as a Novel Ocular Topical Anesthetic: Results from a Multicenter, Randomized Clinical Trial in Patients Undergoing Cataract Surgery

Journal of Ocular Pharmacology and Therapeutics
Purpose: To compare the efficacy and safety of a novel ophthalmic anesthetic, chloroprocaine 3% gel to tetracaine 0.5% eye drops in patients undergoing cataract surgery with phacoemulsification. Methods: This was a prospective, randomized, multicenter, active-controlled, masked-observer, parallel group competitive equivalence study. The study comprised
Michele Figus, Fabrizio Giansanti, Edoardo Villani, Jorge L. Alió, Ladislav Jančo, Stefano Mercuri, Stefano Camnasio, Carlo Cagini   +7 more
openaire   +4 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source