Results 91 to 100 of about 55,609,055 (315)
Sharing data from clinical trials: the rationale for a controlled access approach. [PDF]
, 2015 The move towards increased transparency around clinical trials is welcome. Much focus has been on under-reporting of trials and access to individual patient data to allow independent verification of findings.
Parmar, MK +11 more
core +2 more sources
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Management of Aphthous Ulceration with Topical Quercetin: A Randomized Clinical Trial
The Journal of Contemporary Dental Practice, 2010 Abstract Aim Recurrent aphthous ulceration is the most commonly known oral mucosal disease. Quercetin is a useful therapeutic agent for the treatment of colitis and gastric ulcer. The objective of this study was to determine the effect of topical application of quercetin in the treatment of minor aphthous ulcers.
Ahmed Abd El-Meguid Mostafa, Hamdy +1 more
openaire +2 more sources
Research Report 2006–2007 [PDF]
, 2008 The National Health and Medical Research Council Clinical Trials Centre conducts its own clinical trials, provides expertise and infrastructure for trials run by other groups, and undertakes research aiming to improve both the conduct of trials and the ...
NHMRC Clinical Trials Centre
core
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
The global landscape of particle beam radiotherapy trials over 15 years
Cancer Pathogenesis and TherapyBackground: Particle beam radiotherapy (PBRT), with its advantageous physical and biological properties, has the potential to improve therapeutic outcomes. To elucidate future clinical trial designs and policy decisions, we conducted this cross-sectional
Wei Chen +9 more
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
NEW ADVANCES IN BETA-BLOCKER THERAPY IN HEART FAILURE
Frontiers in Physiology, 2013 The use of -blockers (BB) in heart failure (HF) has been considered a contradiction for many years. Considering HF simply as a state of inadequate systolic function, BB were contraindicated because of their negative effects on myocardial contractility ...
Vincenzo eBarrese +2 more
doaj +1 more source
A statistical investigation of fraud and misconduct in clinical trials [PDF]
Research misconduct can arise In any area of research and can discredit the findings. Research misconduct at any level is unacceptable, especially in a clinical trial.
Al-Marzouki, Sanaa Mohammed
core +1 more source
Conditionally unbiased estimation in phase II/III clinical trials with early stopping for futility [PDF]
, 2013 Seamless phase II/III clinical trials combine traditional phases II and III into a single trial that is conducted in two stages, with stage 1 used to answer phase II objectives such as treatment selection and stage 2 used for the confirmatory analysis ...
Todd, Susan C. +6 more
core +1 more source