Results 101 to 110 of about 565,685 (338)

Vitamin D for the Treatment of Epilepsy: Basic Mechanisms, Animal Models and Clinical Trials

Frontiers in Neurology, 2016
There is increasing evidence supporting dietary and alternative therapies for epilepsy, including the ketogenic diet, modified Atkins diet, and omega-3 fatty acids.
Kevin Pendo, Christopher Michael DeGiorgio, MD   +1 more
doaj   +1 more source

Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression

Molecular Oncology, EarlyView.
Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park, Jae Won Oh, Hyewon Chung, Jung Won Kwon, Yi Rang Na, Kwang Pyo Kim, Seung Hyeok Seok   +6 more
wiley   +1 more source

IMI – industry guidelines and ethical considerations for myopia control report [PDF]

, 2019
PURPOSE. To discuss guidelines and ethical considerations associated with the development and prescription of treatments intended for myopia control (MC). METHODS.
Drove, Bjorn, Gifford, Kate L, Gonzalez-meijome, Jose Manuel, Gray, Lyle, Jones, Lyndon, Kratzer, Timo, Newman, Steve, Nichols, Jason J, Ohlendorf, Arne, Ramdass, Stephanie, Resnikoff, Serge, Santadomigo-Rubido, Jacinto, Schmid, Katrina L, Tan, Donald, Tan, Kai-Ooh, Vera-Diaz, Fuensanta A, Wong, Yee-Ling   +16 more
core   +1 more source

Insights From Pre-Clinical and Clinical Studies on the Role of Innate Inflammation in Atherosclerosis Regression

Frontiers in Cardiovascular Medicine, 2018
Atherosclerosis, the underlying cause of coronary artery (CAD) and other cardiovascular diseases, is initiated by macrophage-mediated immune responses to lipoprotein and cholesterol accumulation in artery walls, which result in the formation of plaques ...
Karishma Rahman, Edward A. Fisher
doaj   +1 more source

Plasma lipidomic and metabolomic profiles in high‐grade glioma patients before and after 72‐h presurgery water‐only fasting

Molecular Oncology, EarlyView.
Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé, Lisa Hahnefeld, Katharina J. Wenger, Donat Kögel, Joachim Steinbach, Gerd Geisslinger, Michael W. Ronellenfitsch, Irmgard Tegeder   +7 more
wiley   +1 more source

The development of QUADAS : a tool for the quality assessment of studies of diagnostic accuracy included in systematic reviews [PDF]

, 2003
BACKGROUND: In the era of evidence based medicine, with systematic reviews as its cornerstone, adequate quality assessment tools should be available.
Anne WS Rutjes, AR Jadad, DL Streiner, J Deeks, Johannes B Reitsma, Jos Kleijnen, KF Schulz, M Kerr, P Bossuyt, P Glasziou, P Juni, P Juni, Patrick MM Bossuyt, Penny Whiting, S Greenland   +14 more
core   +4 more sources

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

Molecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak, Żaneta Zarębska, Marcin P. Sajek, Adriana Grabowska, Alessia Buratin, Paweł Głodowicz, Julia O. Misiorek, Konrad Kuczyński, Stefania Bortoluzzi, Marek Żywicki, Jan G. Kosiński, Agnieszka Rybak‐Wolf, Rafał Piestrzeniewicz, Anna M. Barciszewska, Katarzyna Rolle   +14 more
wiley   +1 more source

A new cognitive evaluation battery for Down syndrome and its relevance for clinical trials

Frontiers in Psychology, 2015
The recent prospect of pharmaceutical interventions for cognitive impairment of Down syndrome(DS) has boosted a number of clinical trials in this population.
Susana ede Sola, Susana ede Sola, Rafael ede la Torre, Rafael ede la Torre, Rafael ede la Torre, Gonzalo eSanchez-Benavides, Gonzalo eSanchez-Benavides, Bessy eBenejam, Aida eCuenca-Royo, Aida eCuenca-Royo, Laura edel Hoyo, Joan eRodriguez, Silvina eCatuara-Solarz, Judit eSanchez-Gutiérrez, Ivan eDueñas-Espin, Ivan eDueñas-Espin, Gimena eHernandez, Gimena eHernandez, Jordi ePeña-Casanova, Jordi ePeña-Casanova, Klaus eLangohr, Klaus eLangohr, Sebastià eVidela, Henri eBléhaut, Magi eFarré, Magi eFarré, Mara eDierssen, Mara eDierssen, the eTESDAD Study Group   +28 more
doaj   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

In silico assessment of biomedical products: the conundrum of rare but not so rare events in two case studies [PDF]

, 2017
In silico clinical trials, defined as “The use of individualized computer simulation in the development or regulatory evaluation of a medicinal product, medical device, or medical intervention,” have been proposed as a possible strategy to reduce the ...
Adam Himes, American Diabetes Association, Anderson SM, Andreassen S, Bassingthwaighte JB, Bassingthwaighte JB, Basu R, Baxter W, Benson N, Bode BW, Boris Kovatchev, Bosi GM, Bosmans L, Britten RD, Campbell MP, Carriero A, Chen L, Christie GR, Claudio Cobelli, Cobelli C, Cobelli C, Cooling MT, Cristofolini L, Dalla Man C, Danaei G, DiMasi JA, El Makssoud H, Falcinelli C, Fernandez JW, Fernandez JW, Fregly BJ, Fritsch A, Gasser TC, Ghanbari J, Haddad T, Haddad T, Hamed E, Heidlauf T, Hinshaw L, Hunter PJ, Kennergren C, Kohout J, Kovatchev BP, Kropff J, Krueger MW, Lavagnino M, Lehmann ED, Leone-Bay A, Li X, Li X, Lloyd CM, Lodola A, Lungu A, Maceri F, Mah JT, Marco Viceconti, Mark Palmer, Martelli S, Martelli S, Martelli S, Meagher JM, Morris PD, Nair KS, Nørgaard BL, Oberhofer K, Panteleon AE, Porzio S, Predoi-Racila M, Qasim M, Ravera EP, Renard E, Riccio AI, Salzsieder E, Scheys L, Scheys L, Shaw JE, Shim VB, Smith DW, Smith N, Sorensen JT, Srinivasan R, Steil GM, Swee JKY, Szczesny SE, Tarek Haddad, The Diabetes Control and Complications Trial Research Group, Toffanin C, UK Prospective Diabetes Study Group (UKPDS), Vettoretti M, Viceconti M, Viceconti M, Visentin R, Visentin R, Visentin R, Visentin R, Weis JA, Zarins CK, Zimmet P   +97 more
core   +1 more source