Results 281 to 290 of about 565,685 (338)

Timely Topics in Statistical Methods for Clinical Trials

Annual Review of Biophysics and Bioengineering, 1982
Clinical trials provide information on the absolute and relative efficacy and side effects of medical treatments. These studies range from the well-designed, randomized controlled trial to a study of a single treat­ ment on a series of patients compared to the responses of previous patients treated another way.
Thomas A. Louis, Frederick Mosteller, Bucknam McPeek   +2 more
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Some topics of current interest in clinical trials

Canadian Journal of Statistics, 1992
AbstractAfter a short review of the development of the modern approach to the design of clinical trials, attention is focused on the wide variety of trials, their ethical constraints, the criteria for stopping trials, and the possible use of Bayesian methods. Brief discussions are then presented of two specific topics: the analysis of categorical data,
P. Armitage
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Reproducibility of Clinical Trials of Topical Glucocorticosteroids [PDF]

International Journal of Dermatology, 1983
ABSTRACT:Clinical trials of topical glucocorticosteroids employ a variety of evaluating methods. This makes it difficult to assess the relative strengths of the products without resorting to direct comparative trials between them. We propose a standardized evaluation system for this class of pharmaceuticals that can easily be adopted by any competent ...
Torsten Fredriksson, Lars Salde, Allan Lassus   +2 more
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Clinical Trial of Topical Erythromycin in Inflammatory Acne

Drug Intelligence & Clinical Pharmacy, 1981
Sixty-nine informed subjects participated in a split-face, double-blind trial of topical erythromycin base 2% in Vehicle/N® versus Vehicle/N® alone. All subjects had grades II or III acne as described by Pillsbury. Study solutions were assigned to a randomly selected side of the subject's face. Solutions were applied twice daily.
Randall A. Prince, Douglas A. Busch, Charles D. Hepler, Harley G. Feldick   +3 more
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Amphotericin as a Topical Antifungal Antibiotic

A.M.A. Archives of Dermatology, 1959
A previously unknown Streptomyces species, isolated from a soil sample obtained at Tembladora, on the Orinoco River in South America, has been found to produce two amphoteric antifungal agents which have been named amphotericin A and amphotericin B. 1 Studies of their physical properties reveal slight differences between the infrared absorption spectra
John M. Knox, Wilson M. Fraser
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Clinical Trial of Topical Disodium Chromoglycate in Vernal Keratoconjunctivitis

Ophthalmologica, 1978
The clinical picture of Spring catarrh was studied in 96 cases. The duration of the disease was found to be 3.5 +/- 2.6 years. It exists all the year round with a higher frequency between April and August. Male children were affected about three times more frequently than females. The effect of DSCG was studied in 20 cases.
Samerra'e S, Sayegh F, Khateeb M
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Topical tretinoin in chronic rhinosinusitis with nasal polyps: a randomized clinical trial [PDF]

International Forum of Allergy & Rhinology, 2021
BackgroundChronic rhinosinusitis with nasal polyps (CRSwNP) is usually treated with corticosteroids, given their anti‐inflammatory effects. Unlike the nasal administration, the oral and ocular use of tretinoin, an immunoregulatory drug, is well established. Therefore, tretinoin was thought to act on nasal polyps, and possible adverse and/or therapeutic
Dioze Guadagnini, Fernando Augusto Lima Marson, Fernando Augusto Lima Marson, Emerson Taro Inoue Sakuma, Mariana Dalbo Contrera Toro, Eulalia Sakano, Icléia Siqueira Barreto, Sergio Dertkigil, Marcelo Augusto Antonio, Marcelo Hamilton Sampaio   +9 more
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Influence of the Base on the Results of Clinical Trials with Topical Corticosteroids

Dermatology, 1979
A comparative trial between betamethasone valerate and halcinonide has shown the former to be superior, thus contradicting the results from other trials. It is thought that the discrepancy is due to differences in the nature of the preparations used in the various studies.
Dorothy I. Vollum, Christopher G. Sparkes   +1 more
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Topical metformin in the treatment of melasma: A preliminary clinical trial

Journal of Cosmetic Dermatology, 2019
AbstractBackgroundMelasma is a common acquired pigmentary disorder characterized by symmetric hyperpigmented macules on the face. Triple combination cream (TCC) remains the gold standard treatment but its prolonged use often causes adverse effects. Recently, studies have shown that topical metformin has melanopenic action.AimsTo evaluate the safety and
Ravikumar Banavase Channakeshavaiah, Naveen Kumar Andanooru Chandrappa   +1 more
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