Results 31 to 40 of about 624,126 (316)

Patient and public involvement in the design of clinical trials: An overview of systematic reviews [PDF]

, 2017
BACKGROUNDFunders encourage lay-volunteer inclusion in research. There are controversy and resistance, given concerns of role confusion, exploratory methods, and limited evidence about what value lay-volunteers bring to research.
Albarqouni, Loai, Burls, Amanda, Clarke, Mike, Kirkpatrick, Jo, Liew, Su May, Price, Amy, Roberts, Nia W   +6 more
core   +3 more sources

A comparative randomized clinical trial evaluating the efficacy and safety of tacrolimus versus hydrocortisone as a topical treatment of atopic dermatitis in children

Frontiers in Pharmacology, 2023
Background: Atopic dermatitis (AD) aetiology is not exactly identified, but it is characterized by pruritic skin reactions with elevation in the levels of inflammatory markers. Despite the fact that Corticosteroids are the mainstay therapy in the management of AD, they have many local and systemic adverse effects.Objective: The aim of this study is to ...
Amal A. Mohamed, Radwa El Borolossy, Eman M. Salah, Maha S. Hussein, Nashwa M. Muharram, Naglaa Elsalawy, Mona G. Khalil, Maha O. Mahmoud, Reham Y. El-Amir, Heba M. A. Elsanhory, Nourelhuda Ahmed, Ahmed S. Adaroas, Mahmoud Montaser, Amal A. El Kholy   +13 more
openaire   +3 more sources

Knowledge and Attitudes Towards Clinical Trial Participation in Oman: A cross-sectional study

Sultan Qaboos University Medical Journal, 2018
Objectives: Clinical trials are prospective studies on human subjects designed to answer various clinical questions. However, only a limited number of clinical trials have been conducted in Oman.
Hussain Al-Lawati, Khalid Al-Baimani, Mahra Al-Zadjali, Nasra Al-Obaidani, Ziyana Al-Kiyumi, Murtadha K. Al-Khabori   +5 more
doaj   +1 more source

Everolimus as first line therapy for pancreatic neuroendocrine tumours: current knowledge and future perspectives [PDF]

, 2017
urpose Everolimus has been shown to be effective for advanced pancreatic neuroendocrine tumours (pNETs), but its positioning in the therapeutic algorithm for pNETs is matter of debate.
Badalamenti, G., Colao, A., Faggiano, A., Fanciulli, G., Gallo, M., Giordano, C., Malandrino, P., Rota, F.   +7 more
core   +1 more source

Clinical Trials in Portugal: Past and Future. Position Paper from the Colleges of Clinical Pharmacology and Pharmaceutical Medicine

Acta Médica Portuguesa
N/a.
Filipa Borges-Carneiro, Miguel Torre Souto, Isabel Silva, Paula Leão Moreira, Paula Ferraz de Oliveira, Diogo José Lopes, Luís Figueira, Marta Reina-Couto, Luís Cunha-Miranda, Diogo Ponces Bento, Fernando Magro   +10 more
doaj   +1 more source

Big data and data repurposing – using existing data to answer new questions in vascular dementia research [PDF]

, 2017
Introduction: Traditional approaches to clinical research have, as yet, failed to provide effective treatments for vascular dementia (VaD). Novel approaches to collation and synthesis of data may allow for time and cost efficient hypothesis generating ...
A Abdul-Rahim, AH Noel-Storr, Andreas Charidimou, Charlotte J. Roberts, CN Martyn, Craig W. Ritchie, CW Ritchie, D Jang, D Kerr, D Religa, DA Levine, Deborah A. Levine, Fergus N. Doubal, G Mead, G Perera, G Perera, G Rands, G. David Batty, GE Mead, Gillian Mead, HA Mucke, Hermann A. M. Mucke, HL Dunn, I Chalmers, J Danesh, J Mindell, J Sultana, JPA Ioannidis, L Gray, M Ali, M Brainin, M Jokela, M Porter, M Porter, Maria Eriksdotter, Martin Hofmann-Apitius, Myzoon Ali, NL Catlett, P Langhorne, R Lees, R Patel, R Stewart, R Xu, Robert Stewart, S Garcia-Ptacek, SK McCann, T Hoffman, T Skillbäck, TC Russ, TC Russ, TC Russ, TC Russ, Terence J. Quinn, TJ Quinn, Tom C. Russ, William Whiteley, Yun-Hee Kim   +56 more
core   +8 more sources

The Cricothyroid versus Spray-As-You-Go Method for Topical Anesthesia during Flexible Bronchoscopy: The CRISP Randomized Clinical Trial

Respiration, 2019
<b><i>Background:</i></b> Comparative characteristics of the cricothyroid injection and spray-as-you-go methods for lidocaine administration during diagnostic flexible bronchoscopy are not clear. <b><i>Objectives:</i></b> Co-primary outcomes were comparison of cough count from bronchoscope introduction ...
Karan Madan, Saurabh Mittal, Nishkarsh Gupta, Shiba Kalyan Biswal, Pawan Tiwari, Vijay Hadda, Anant Mohan, Randeep Guleria   +7 more
openaire   +5 more sources

Novel trial designs: Master protocol trials

Perspectives in Clinical Research
Conventional trial designs are resource and time-intensive. To accelerate the process of testing new interventions, we now have several novel research trial designs.
Priya Ranganathan, Vishal Deo, C. S. Pramesh, Mahesh P. Parmar   +3 more
doaj   +1 more source

Asking new questions with old data: The Centralized Open-Access Rehabilitation database for Stroke (SCOAR).

Frontiers in Neurology, 2016
Background: This paper introduces a tool for streamlining data integration in rehabilitation science, the Centralized Open-Access Rehabilitation database for Stroke (SCOAR), which allows researchers to quickly visualize relationships among variables ...
Keith Lohse, Sydney Y Schaefer, Sydney Y Schaefer, Adam Raikes, Lara Boyd, Catherine E Lang   +5 more
doaj   +1 more source

Does soy protein supplementation affect body composition in healthy exerciser adults? A systematic review and meta-analysis of clinical trials [PDF]

, 2019
Background objectives: The effects of soy protein supplementation on anthropometric parameters and body composition indices of healthy adults is equivocal.
Asbaghi, O., Clark, C.C.T., Falahi, E., Jafarnejad, S., Khosroshahi, M.Z., Rad, E.Y., Saboori, S.   +6 more
core   +3 more sources