Results 51 to 60 of about 3,728 (217)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Management of Aphthous Ulceration with Topical Quercetin: A Randomized Clinical Trial

The Journal of Contemporary Dental Practice, 2010
Abstract Aim Recurrent aphthous ulceration is the most commonly known oral mucosal disease. Quercetin is a useful therapeutic agent for the treatment of colitis and gastric ulcer. The objective of this study was to determine the effect of topical application of quercetin in the treatment of minor aphthous ulcers.
Ahmed Abd El-Meguid Mostafa, Hamdy, Mohamed Abd El-Moneam, Ibrahem   +1 more
openaire   +2 more sources

Preventing Chronic Disease (PCD) [PDF]

IntroductionDisparities in enrollment of adults in cancer clinical trials are well documented, but little is known about the attention given to this topic in comprehensive cancer control (CCC) plans.

core  

Hyperthermia-related clinical trials on cancer treatment within the ClinicalTrials.gov registry

, 2015
PURPOSE Hyperthermia has been shown to improve the effectiveness of chemotherapy and radiotherapy in the treatment of cancer. This paper summarises all recent clinical trials registered in the ClinicalTrials.gov registry.
Crezee, H, Crezee, Hans, Cihoric, Nikola, Bodis, Stephan, Aebersold, Daniel M, van Rhoon, Gerard, Nadobny, Jacek, Ghadjar, Pirus, Wust, Peter, Tsikkinis, A, Aebersold, DM, Budach, V, Cihoric, N, Aebersold, Daniel M., Aebersold, Daniel, Wust, P, Budach, Volker, Beck, Marcus, Beck, M, Bodis, S, Ghadjar, P, Tsikkinis, Alexandros, Nadobny, J   +22 more
core   +1 more source

LIFELAX – diet and LIFEstyle versus LAXatives in the management of chronic constipation in older people: randomised controlled trial [PDF]

, 2010
Objectives: To investigate the clinical effectiveness and cost-effectiveness of laxatives versus dietary and lifestyle advice, and standardised versus personalised dietary and lifestyle advice.Design: A prospective, pragmatic, three-armed cluster ...
May, Carl, McMeekin, P, Rubin, G, G Rubin, Bond, John, Corbett, S., May, C., Adamson, Ashley, Adamson, A., A Adamson, E McColl, Bond, J, Lake, AA, Heaven, Ben, Lake, A.A., May, C, Speed, C, Vanoli, A., Lake, A. A.; id_orcid, McColl, E., Speed, C., C Speed, Adamson, A, Vanoli, A, Moynihan, P, B Heaven, A Vanoli, McColl, E, Rubin, G., Corbett, Sally, Lake, Amelia, Heaven, B, Vanoli, Alessandra, Steen, Nick, IN Steen, Heaven, B., Steen, IN, J Bond, Bond, J., C May, Speed, Chris, McMeekin, Peter, McMeekin, P., McColl, Elaine, P McMeekin, Steen, I. N., Rubin, Gregory, AA Lake, Corbett, S, S Corbett, Steen, I.N., Moynihan, P., P Moynihan, Lake, A. A.   +53 more
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Focus on You: Cancer clinical trials perspectives

, 2016
BackgroundClinical trials test new ways to prevent, detect, diagnose, or treat diseases. Researchers have found that minority patients are willing to participate in clinical trials, yet these patients have barriers which hinder their access to trials ...
Newman, Antoinette F., Swain, Sandra M., Sherrie F. Wallington, Sandra M. Swain, Robinson, Brandi N., Wallington, Sherrie F., Brandi N. Robinson, Antoinette F. Newman   +7 more
core   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Clinical trials risk: a new assessment tool

, 2011
PurposeRisk management is becoming an increasingly important topic in healthcare. The dangers of conducting clinical trials were brought to the attention of the public by the media in 2006 with the TGN1412 phase 1 clinical trial.
Anthony Scott Brown
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source