Results 41 to 50 of about 624,126 (316)
Targeting mTOR in Pancreatic Ductal Adenocarcinoma
Frontiers in Oncology, 2016 Treatment options for advanced pancreatic ductal adenocarcinoma (PDAC) are limited, however, new therapies targeting specific tumor-related molecular characteristics may help certain patient cohorts. Emerging preclinical data has shown that inhibition of
Sentia eIriana +6 more
doaj +1 more source
Inadequate reporting quality of registered genome editing trials: an observational study
BMC Medical Research Methodology, 2022 Background To assess registration completeness and safety data of trials on human genome editing (HGE) reported in primary registries and published in journals, as HGE has safety and ethical problems, including the risk of undesirable and unpredictable ...
Diana Jurić +2 more
doaj +1 more source
Could Fractional Exhaled Nitric Oxide Test be Useful in Predicting Inhaled Corticosteroid Responsiveness in Chronic Cough? A Systematic Review [PDF]
, 2016 © 2016 Background Fractional exhaled nitric oxide (FENO) is a safe and convenient test for assessing T H 2 airway inflammation, which is potentially useful in the management of patients with chronic cough.
Chang, Yoon-Seok +15 more
core +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács +8 more
wiley +1 more source
Exosomes and Immune Response in Cancer: Friends or Foes?
Frontiers in Immunology, 2018 Exosomes are a type of extracellular vesicle whose study has grown exponentially in recent years. This led to the understanding that these structures, far from being inert waste by-products of cellular functioning, are active players in intercellular ...
Francisco M. Barros +10 more
doaj +1 more source
An alternative approach to deal with the absence of clinical trials: a proportional meta-analysis of case series studies [PDF]
Acta Cirúrgica Brasileira, 2013 PURPOSE: Systematic reviews are criticized for frequently offering inconsistent evidences and absence of straightforward recommendations. Their value seems to be depreciated when the conclusions are uncertain.
Regina El Dib +2 more
doaj +2 more sources
Issues for countries considering introducing the "fourth hurdle": The case of Hungary [PDF]
, 2004 Objectives: This study outlines the needs and current development of the "fourth hurdle" (i.e., requirement of effectiveness and cost-effectiveness data for drug coverage policy decisions) in Hungary, describes the legal background and seeks to address ...
Boncz, I, Drummond, M, Gulacsi, L
core +1 more source
Journal of Cosmetic DermatologyAbstractIntroductionMelasma is a chronic hyperpigmentation disorder, and its treatment poses a challenge to dermatologists due to its chronicity and resistance to conventional therapies. Oral isoniazid is used for the treatment of tuberculosis. One of us had previously showed that topical isoniazid exerts a strong depigmenting action in animal models ...
Najmeh, Ahramiyanpour +5 more
openaire +2 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background and Aims Wilms tumour (WT) has excellent event‐free and overall survival (OS). However, small differences exist between countries participating in the same international study. This led us to examine variation in adherence to protocol recommendations as a potential contributing factor.
Suzanne Tugnait +23 more
wiley +1 more source
, 2018 Clinical trial registries can be used to monitor the production of trial evidence and signal when systematic reviews become out of date. However, this use has been limited to date due to the extensive manual review required to search for and screen ...
Bashir, Rabia +5 more
core +1 more source