Results 41 to 50 of about 332,732 (168)

The role of machine learning in clinical research: transforming the future of evidence generation

Trials, 2021
Background Interest in the application of machine learning (ML) to the design, conduct, and analysis of clinical trials has grown, but the evidence base for such applications has not been surveyed.
E. Hope Weissler, Tristan Naumann, Tomas Andersson, Rajesh Ranganath, Olivier Elemento, Yuan Luo, Daniel F. Freitag, James Benoit, Michael C. Hughes, Faisal Khan, Paul Slater, Khader Shameer, Matthew Roe, Emmette Hutchison, Scott H. Kollins, Uli Broedl, Zhaoling Meng, Jennifer L. Wong, Lesley Curtis, Erich Huang, Marzyeh Ghassemi   +20 more
doaj   +1 more source

Translational concepts of mGluR5 in synaptic diseases of the brain

Frontiers in Pharmacology, 2012
The G-protein coupled receptor family of glutamate receptors, termed metabotropic glutamate receptors (mGluRs), are implicated in numerous cellular mechanisms ranging from neural development to the processing of cognitive, sensory, and motor information.
Thomas M Piers, Dong Hyun eKim, Byeong C Kim, Byeong C Kim, Philip eRegan, Philip eRegan, Philip eRegan, Daniel John Whitcomb, Kwangwook eCho, Kwangwook eCho   +9 more
doaj   +1 more source

Vitamin D for the Treatment of Epilepsy: Basic Mechanisms, Animal Models and Clinical Trials

Frontiers in Neurology, 2016
There is increasing evidence supporting dietary and alternative therapies for epilepsy, including the ketogenic diet, modified Atkins diet, and omega-3 fatty acids.
Kevin Pendo, Christopher Michael DeGiorgio, MD   +1 more
doaj   +1 more source

Lessons learned from two randomized controlled trials: CITIES and STOP-DKD

Contemporary Clinical Trials Communications, 2020
Background: Even well-designed, theoretically driven clinical trials can fall short of achieving the desired clinical outcomes. Our research team had an opportunity to conduct two randomized controlled trials that were enrolling patients in parallel ...
Leah L. Zullig, Megan M. Oakes, Felicia McCant, Hayden B. Bosworth   +3 more
doaj   +1 more source

NEW ADVANCES IN BETA-BLOCKER THERAPY IN HEART FAILURE

Frontiers in Physiology, 2013
The use of -blockers (BB) in heart failure (HF) has been considered a contradiction for many years. Considering HF simply as a state of inadequate systolic function, BB were contraindicated because of their negative effects on myocardial contractility ...
Vincenzo eBarrese, Maurizio eTaglialatela, Maurizio eTaglialatela   +2 more
doaj   +1 more source

Olive Leaf Extract as a New Topical Management for Oral Mucositis Following Chemotherapy: A Microbiological Examination, Experimental Animal Study and Clinical Trial [PDF]

Pharmaceutica Analytica Acta, 2013
Oral mucositis is a common complication of intensive cancer chemotherapy and radiotherapy. Olive leaf extract was investigated through microbiological, experimental animal studies and clinical trial. The results were compared with the action of benzydamine HCl as positive control and normal saline as negative control.
openaire   +1 more source

Study Design Characteristics and Pharmacological Mechanisms in International Clinical Trials Registry Platform: Registered Clinical Trials on Antiviral Drugs for COVID-19

Drug Design, Development and Therapy, 2020
Weilong Zhang,1,* Yinghua Lv,1,* Juan Yang,1 Yunhui Chen,2 Yingchun He,1 Jihan Huang1 1Center for Drug Clinical Research, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203 ...
Zhang W, Lv Y, Yang J, Chen Y, He Y, Huang J   +5 more
doaj  

Is it possible to estimate the minimal clinically important treatment effect needed to change practice in preterm birth prevention? Results of an obstetrician survey used to support the design of a trial

BMC Medical Research Methodology, 2012
Background Sample sizes for obstetrical trials are often based on the opinion of investigators about clinically important effect size. We surveyed Canadian obstetricians to investigate clinically important effect sizes required before introducing new ...
Ross Sue, Milne Jill, Dwinnell Shannon, Tang Selphee, Wood Stephen   +4 more
doaj   +1 more source

Insights From Pre-Clinical and Clinical Studies on the Role of Innate Inflammation in Atherosclerosis Regression

Frontiers in Cardiovascular Medicine, 2018
Atherosclerosis, the underlying cause of coronary artery (CAD) and other cardiovascular diseases, is initiated by macrophage-mediated immune responses to lipoprotein and cholesterol accumulation in artery walls, which result in the formation of plaques ...
Karishma Rahman, Edward A. Fisher
doaj   +1 more source

Chloroprocaine 3% Gel as a Novel Ocular Topical Anesthetic: Results from a Multicenter, Randomized Clinical Trial in Patients Undergoing Cataract Surgery

Journal of Ocular Pharmacology and Therapeutics
Purpose: To compare the efficacy and safety of a novel ophthalmic anesthetic, chloroprocaine 3% gel to tetracaine 0.5% eye drops in patients undergoing cataract surgery with phacoemulsification. Methods: This was a prospective, randomized, multicenter, active-controlled, masked-observer, parallel group competitive equivalence study. The study comprised
Michele Figus, Fabrizio Giansanti, Edoardo Villani, Jorge L. Alió, Ladislav Jančo, Stefano Mercuri, Stefano Camnasio, Carlo Cagini   +7 more
openaire   +4 more sources