Results 41 to 50 of about 565,685 (338)
The role of corruption and unethical behaviour in precluding the placement of industry sponsored clinical trials in sub-Saharan Africa: stakeholder views [PDF]
, 2016 Clinical trials still represent the gold standard in testing the safety and efficacy of new and existing treatments. However, developing regions including sub-Saharan Africa remain underrepresented in pharmaceutical industry sponsored trials for a number
Atkinson, Jacqueline, Egharevba, Efe
core +2 more sources
Exosomes and Immune Response in Cancer: Friends or Foes?
Frontiers in Immunology, 2018 Exosomes are a type of extracellular vesicle whose study has grown exponentially in recent years. This led to the understanding that these structures, far from being inert waste by-products of cellular functioning, are active players in intercellular ...
Francisco M. Barros +10 more
doaj +1 more source
An alternative approach to deal with the absence of clinical trials: a proportional meta-analysis of case series studies [PDF]
Acta Cirúrgica Brasileira, 2013 PURPOSE: Systematic reviews are criticized for frequently offering inconsistent evidences and absence of straightforward recommendations. Their value seems to be depreciated when the conclusions are uncertain.
Regina El Dib +2 more
doaj +2 more sources
Topical Tacrolimus for High-risk Corneal Transplantation: A randomized, clinical trial
BMC Ophthalmology, 2022 Abstract Immunological rejection after high-risk penetrating keratoplasty (PKP) remains a major problem. We investigated the efficacy and safety of topical tacrolimus (TAC) in these patients. This randomised clinical trial performed at a tertiary referral hospital included eyes of patients with a history of PKP, graft rejection, atopic ...
Shimazaki, J +4 more
openaire +4 more sources
Targeting mTOR in Pancreatic Ductal Adenocarcinoma
Frontiers in Oncology, 2016 Treatment options for advanced pancreatic ductal adenocarcinoma (PDAC) are limited, however, new therapies targeting specific tumor-related molecular characteristics may help certain patient cohorts. Emerging preclinical data has shown that inhibition of
Sentia eIriana +6 more
doaj +1 more source
Drug Design, Development and Therapy, 2015 Treatment of melasma is unsatisfactory most of the times. Hormonal role is shown to exist in pathogenesis of the melasma, and sex-hormone related drugs may have an effect on melasma.To investigate efficacy of 1% flutamide cream versus 4% hydroquinone cream on melasma.In a parallel randomized clinical trial, 74 women with melasma were allocated to ...
Hassan Adalatkhah +1 more
openaire +6 more sources
FoxO1 signaling in B cell malignancies and its therapeutic targeting
FEBS Letters, EarlyView.FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac +3 more
wiley +1 more source
Structured review of the patient-reported outcome instruments used in clinical trials in head and neck surgery [PDF]
, 2018 The number of clinical trials that relate to patients with cancer of the head and neck is growing. Patient-reported outcomes, which are rarely the primary outcome, are now an important component, and in this structured review to identify and report the ...
Barraclough, J +4 more
core +2 more sources
Double-blind clinical trial of topical steroids in anterior uveitis. [PDF]
British Journal of Ophthalmology, 1979 We present the results of a double-blind trial comparing the efficacy of betamethasone phosphate 0.1%, clobetasone butyrate 0.1%, and placebo in the treatment of acute unilateral nongranulomatous uveitis. The 2 steroids were equally comparable in improvement of the patients' symptoms, though betamethasone phosphate was significantly more effective than
J A Dunne, J P Travers
openaire +3 more sources