Results 11 to 20 of about 4,045,482 (205)

Exploring clinically relevant dissolution specifications for oral solid dosage forms of weak acid drugs using an in silico modeling and simulation approach

European Journal of Pharmaceutical Sciences, 2021
The aim of this study was to explore clinically relevant dissolution specifications for weak acid drugs using an in silico drug absorption model. Loxoprofen sodium and ibuprofen were used as model drugs in this study. An in silico drug absorption model was developed using Stella Professional software and the prediction model accurately represented the ...
Atsushi, Kambayashi, Chikako, Yomota
openaire   +2 more sources

Clinically-relevant CNVs detected.

, 2022
Clinically-relevant CNVs detected.
Sian Ellard (25182), Kashyap A. Patel (12251414), Michael N. Weedon (10953860), Matthew N. Wakeling (12251417), Sarah E. Flanagan (8415405), Elisa De Franco (8231166), Matthew B. Johnson (1922497), Thomas W. Laver (8415384)   +7 more
core   +1 more source

Effect of divalent metal cations on hydroxyapatite dissolution kinetics relevant to dental caries and erosion. [PDF]

, 2012
PhDIn recent years there has been an increasing awareness of the influence of various trace elements on reducing the progression of dental caries and of erosion. However, there are few clinical and even fewer in-vitro studies of the cariostatic effect of
Lingawi, Hanadi Saud
core   +4 more sources

Development and assessment of a USP Apparatus 3 dissolution test method for sustained-release Nevirapine matrix tablets [PDF]

, 2016
Dissolution testing is a quality control tool used to assess batch-to-batch performance of dosage forms, thereby providing continued assurance of product quality.
Mwila, Chiluba, Khamanga, Sandile M M, Walker, Roderick B   +2 more
core   +1 more source

Intrinsic dissolution simulation of highly and poorly soluble drugs for BCS solubility classification [PDF]

, 2017
Intrinsic dissolution testing allows characterizing drug substances through its dissolution rate when exposed to a specified surface area in a specific dissolution media, This can be used to determine if a drug substance is highly or poorly soluble.
Raimar Löbenberg, Beatriz Ayumi Sakamoto Kakuda, Duque, Marcelo Dutra [UNIFESP], Ferraz, Humberto Gomes, Silva, Daniela Amaral, Sakamoto Kakuda, Beatriz Ayumi [UNIFESP], Carpentieri Rodrigues, Leticia Norma [UNIFESP], Daniela Amaral Silva, Humberto Gomes Ferraz, Lobenberg, Raimar, Marcelo Dutra Duque, Michele Georges Issa, Issa, Michele Georges, Leticia Norma Carpentieri Rodrigues   +13 more
core   +1 more source

Moving and Union Dissolution [PDF]

, 2008
This paper examines the effect of migration and residential mobility on union dissolution among married and cohabiting couples. Moving is a stressful life event, and a large, multidisciplinary litera-ture has shown that family migration often benefits ...
Cooke, T., Boyle, P.J., Kulu, Hill, Mulder, Clara H, Boyle, Paul, Cooke, Thomas, Gayle, V., Mulder, Clara H., Kulu, H., Gayle, Vernon, Mulder, C.H., Boyle, Paul J.   +11 more
core   +2 more sources

Experimental determination of plagioclase dissolution rates as a function of its composition and pH at 22°C. [PDF]

, 2014
The steady-state, far-from-equilibrium dissolution rates of nine distinct plagioclases ranging in composition from An2 to An89 were measured in mixed flow reactors at 22 ± 2 C and pH from 2 to 11.
Gudbrandsson S., Wolff-Boenisch D., Gislason S. R. and Oelkers E. H.
core   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

A Holistic Platform Approach for Developing Robust Pulmonary mRNA Delivery: Integrating Novel Phenolic Acid‐Derived Ionizable Lipids and Device Engineering

Advanced Functional Materials, EarlyView.
An integrated pulmonary mRNA delivery platform combining novel biodegradable syringic acid‐derived ionizable lipids, design‐of‐experiments formulation optimization, and vibrating‐mesh nebulizer engineering enabled stable aerosolization and efficient lung delivery.
Neha Kaushal, Younan Ma, Asad Khanmohammed, Dipen Parande, Hanming Zhang, Saket Dolare, Juliet Chen, Apiwat Wangweerawong, Saswata Karmakar, Hongfeng Deng, Frank Koppenhagen, Shraddha Sharma, Eric Reyes, Sherry He, Lianne Boeglin, Caroline Woo, Azadeh Paksa, Ayed Allawzi, Anusha Dias, Gregory Troiano, Shrirang Karve, Frank DeRosa   +21 more
wiley   +1 more source

An Epigenetic Fate Converter Based on Nuclei‐Targeting Lipid Nanoparticles Drives Neuronal Programming of Stem Cells for Spinal Cord Repair

Advanced Functional Materials, EarlyView.
Schematic illustration of LNP‐MPG nuclei‐targeting delivery of HMW‐FGF2 promoting histone acetylation to regulate the fate of DPSCs and treat spinal cord injury. LNPs components include pHMW‐FGF2 plasmid, DSPC, Dlin‐MC3‐DMA, cholesterol, and PEG2000, and are modified with MPG to form HMW‐FGF2@LNP‐MPG (HLM). HLM nuclei‐targets DPSCs to deliver HMW‐FGF2,
Heng Zhou, Qiang Qin, Xiqin Li, Hanyu Ding, Chun Xu, Yan He, Qingsong Ye   +6 more
wiley   +1 more source