Results 21 to 30 of about 4,045,482 (205)

Commentary: Towards Physico-Relevant Dissolution Testing: The Importance of Solid-State Analysis in Dissolution

open access: yes, 2009
Polymorphism and other solid-state phenomena can have effects on many physicochemical properties of pharmaceuticals. In this commentary, some aspects of solid-state pharmaceutics that are important to dissolution testing are highlighted.
Aaltonen, Jaakko   +3 more
core   +1 more source

Genetically Programmed Shape‐Morphing of Engineered Living Materials

open access: yesAdvanced Functional Materials, EarlyView.
Here, bacterial and mammalian engineered living materials (ELMs) are presented, in which living cells direct genetically programmed and enzymatically mediated shape‐morphing. The resulting deformation and shape‐recovery can be actuated in a genetically controlled manner by an ELM incorporating out‐of‐equilibrium counteracting biochemical reactions with
Jan Becker   +7 more
wiley   +1 more source

Comparison Of Dissolution Profiles Of Commercially Available Lamivudine Tablets

open access: yes, 2015
The aim of this study was to investigate the influence of dissolution medium on the in vitro release of lamivudine (100 mg) from four commercially available lamivudine tablets (one reference and three generic). Three different buffer solutions (pH 1.2, 4.
Ozturk, Naile   +2 more
core   +1 more source

Microfluidic Nano‐Assembly of Red‐Blood‐Cell (RBC) Lipids and Components for Engineering Extracellular Vesicles

open access: yesAdvanced Healthcare Materials, EarlyView.
Engineered red blood cell‐derived extracellular vesicles (eRBCEVs) are synthesized via controlled microfluidic assembly from native RBC lipids, enabling tunable encapsulation of proteins, nucleic acids, nanoparticles, and viral vectors. The platform demonstrates reproducible nanoscale architecture, preserved membrane composition, and functional cargo ...
Chiranth K. Nagaraj   +23 more
wiley   +1 more source

Engineering Concentration‐Dependent Intravitreal Mobility via Cyclic Arginine‐Enriched Nanocarrier Surface Modification: In Vivo Proof‐of‐Concept in a Porcine Large Animal Model

open access: yesAdvanced Healthcare Materials, EarlyView.
In this study, Hammer et al. highlight cyclic‐arginine surface engineering as a highly biocompatible, controllable, and concentration‐dependent regulator of intravitreal nanoparticle mobility in vivo in a translational large animal model. The cyclic arginine surface‐modification supports the development of next‐generation biomaterials for long‐acting ...
Maximilian Hammer   +12 more
wiley   +1 more source

Targeting CD300a Signaling With a Phosphatidylserine‐Presenting Hydrogel Rescues Macrophage Dysfunction and Accelerates Diabetic Wound Healing

open access: yesAdvanced Healthcare Materials, EarlyView.
Schematic illustration of the proposed mechanism: PEG/RGD‐PSLs mimic apoptotic cells to engage PS receptors (notably CD300a), transducing an inhibitory signal that suppresses the MyD88/NF‐κB pathway, leading to global anti‐inflammatory and pro‐reparative effects.
Lele Wu   +10 more
wiley   +1 more source

Dataset belonging to: Prediction of clinically relevant adverse drug events in surgical patients

open access: yes, 2018
Contains the data used for the study titled: Prediction of clinically relevant adverse drug events in surgical patients. This dataset consists of data extracted from the P-REVIEW dataset.
Bos, dr. J.M. (Radboud University) DAI=info:eu-repo/dai/nl/310271134   +8 more
core   +1 more source

Self‐Healing Hydrogel‐Enabled Modular Assembly of Bilayered Skin Construct for Hair Follicle Regeneration

open access: yesAdvanced Healthcare Materials, EarlyView.
Self‐healing assembly of two cell‐laden hydrogel layers creates a biomimetic skin construct that restores both dermal and epidermal functions, resulting in accelerated wound healing and enhanced hair follicle regeneration in a full‐thickness skin wound model. ABSTRACT Alopecia remains a pervasive clinical challenge, largely owing to the limited ability
JaeWook Park   +5 more
wiley   +1 more source

Uv Spectrophotometric Method For Determination Of The Dissolution Profile Of Rivaroxaban

open access: yes, 2014
Rivaroxaban is an oral anticoagulant that is the first available orally active direct Factor Xa inhibitor. In this study, a UV spectrophotometric method was developed for the determination of rivaroxaban content in pharmaceutical formulations and the ...
Celebier, Mustafa   +3 more
core   +1 more source

Liquisolid technique for dissolution rate enhancement of a high dose water-insoluble drug (carbamazepine) [PDF]

open access: yes, 2007
Different liquisolid formulations of carbamazepine were accomplished by dissolving the drug in the non-toxic hydrophilic liquids, and adsorbing the solution onto the surface of silica.
Yousef Javadzadeh   +8 more
core   +1 more source

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