Results 91 to 100 of about 4,021 (200)

Time-Resolved Pharmacological Studies using Automated, On-line Monitoring of Five Parallel Suspension Cultures

Scientific Reports, 2017
Early stage pharmacological studies rely on in vitro methodologies for screening and testing compounds. Conventional assays based on endpoint measurements provide limited information because the lack in temporal resolution may not determine the ...
Ala A. Alhusban, Michael C. Breadmore, Nuri Gueven, Rosanne M. Guijt   +3 more
doaj   +1 more source

Copper/zinc chelation by clioquinol reduces spinal cord white matter damage and behavioral deficits in a murine MOG-induced multiple sclerosis model

Neurobiology of Disease, 2013
The present study aimed to evaluate the therapeutic potential of clioquinol (CQ), a metal chelator, on multiple sclerosis pathogenesis. Experimental autoimmune encephalomyelitis was induced by immunization with myelin oligodendrocyte glycoprotein (MOG(35–
Bo Young Choi, Bong Geom Jang, Jin Hee Kim, Jae-Nam Seo, Guang Wu, Min Sohn, Tae Nyoung Chung, Sang Won Suh   +7 more
doaj   +1 more source

Uji Tempel dengan Finn dan Iq Chambers pada Pasien Dermatitis Kontak Alergi di Rumah Sakit Umum Pusat Dr. Mohammad Hoesin Palembang [PDF]

, 2014
Uji tempel telah diakui secara universal sebagai alat diagnostik untuk diagnosis dermatitis kontak alergi . Berbagai penelitian telah dilakukan untuk meningkatkan standarisasi metode ini , tapi keandalan dan reproduktifitas uji tempel masih menjadi ...
Fitriyani, F. (Fitriyani), Thaha, M. A. (M), Tjekyan, R. M. (R), Y, Y. F. (Yulia)   +3 more
core  

Interventions for skin changes caused by nerve damage in leprosy

São Paulo Medical Journal
BACKGROUND More than three million persons are disabled by leprosy worldwide. The main complication of sensory nerve damage is neuropathic ulceration, particularly of the feet. In this review we explored interventions that can prevent and treat secondary
Liv Merete Reinar, Louise Forsetlund, Arild Bjrndal, Diana Lockwood   +3 more
doaj   +1 more source

Pathogenesis of Alzheimer's Disease: Molecular and Cellular Mechanisms [PDF]

, 2007
peer reviewedAlzheimer's disease is worldwide the leading cause of dementia in the elderly. Senile plaques and neurofibrillary tangles are together with neuronal loss and cortical atrophy characteristic neuropathological features of the disease.
Bouhy, D., Govaerts, L., Schoenen, Jean
core  

Two hydroxy pyridinecarboxylic acid derivatives as a possible chelating agents in neurodegenerative disease; equilibrium complexation studies with Cu(II), Zn(II). [PDF]

, 2014
The metal ion chelators 4-hydroxy-5-methyl-3-pyridinecarboxylic acid (DQ5) and 1,5-dimethyl-4-hydroxy-3-pyridinecarboxylic acid (DQ715) and Cu(II) and Zn(II) were investigated with the aim to restore the homeostasis of the brain Cu(II) and Zn(II) in ...
Dean, Annalisa, Di Marco, Valerio B., Gandin, Valentina, Jakusch, Tamás, Kiss, Tamás, Marzano, Christine, Nagy, Nóra Veronika, Sija, Éva   +7 more
core  

QM, Fukui function, molecular docking, molecular dynamics investigation on Human Estrogen Receptor (HER) with Clioquinol

Chemical Physics Impact
Clioquinol is an antifungal medication that is used to treat skin diseases such as dermatitis, foot inflammation, sports itch, and ringworm The electron localization and delocalization indices in position space are further quantum chemical instruments ...
Chandramohan Uma Maheswari
doaj   +1 more source

How reliable and robust are current biomarkers for copper status? - reply by Danzeisen et al [PDF]

, 2017
The response by Brewer & Althaus to our recent review on biomarkers for Cu(1) bears testimony that the subject is topical and of public, scientific and commercial ...
Araya, Magdalena, Danzeisen, Ruth, Harrison, Brenda, Keen, Carl, McArdle, Harry J., Solioz, Marc, Thiele, Dennis   +6 more
core  

Nanodrug‐Engineered Exosomes Achieve a Jointly Dual‐Pathway Inhibition on Cuproptosis

Advanced Science
Cuproptosis, caused by an intracellular overload of copper (Cu) ions and overexpression of ferredoxin 1 (FDX1), is identified for its regulatory role in the skin wound healing process.
Hanxiao Sun, Yang Zou, Zhengtai Chen, Yan He, Kai Ye, Huan Liu, Lihong Qiu, Yufan Zhang, Yuexue Mai, Xinghong Chen, Zhengwei Mao, Wei Wang, Chenggang Yi   +12 more
doaj   +1 more source

Alzheimer's disease immunization strategies : a review of current research [PDF]

, 2009
Scholarly project (M.S.)
Sirgedas, Laura Ona
core   +1 more source