Anticancer activity of the iron facilitator LS081 [PDF]
, 2011 Background Cancer cells have increased levels of transferrin receptor and lower levels of ferritin, an iron deficient phenotype that has led to the use of iron chelators to further deplete cells of iron and limit cancer cell growth.
Zhen Li +3 more
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A Novel Targeted and High‐Efficiency Nanosystem for Combinational Therapy for Alzheimer's Disease
Advanced Science, 2020 Alzheimer's disease (AD) remains the most prevalent neurodegenerative disease, and no effective treatment is available yet. Metal‐ion‐triggered aggregates of amyloid‐beta (Aβ) peptide and acetylcholine imbalance are reported to be possible factors in AD ...
Han Yang +10 more
doaj +1 more source
Pharmacology & Therapeutics, 2019 Clioquinol, one of the first mass-produced drugs, was considered safe and efficacious for many years. It was used as an antifungal and an antiprotozoal drug until it was linked to an outbreak of subacute myelo-optic neuropathy (SMON), a debilitating disease almost exclusively confined to Japan.
Dominique R, Perez +2 more
openaire +3 more sources
Modulation of iron metabolism in aging and in Alzheimer's disease: relevance of the choroid plexus [PDF]
, 2012 Iron is essential for mammalian cellular homeostasis. However, in excess, it promotes free radical formation and is associated with aging-related progressive deterioration and with neurodegenerative disorders such as Alzheimer's disease (AD).
Ferreira, A. C. +7 more
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Iron and Alzheimer’s Disease: From Pathogenesis to Therapeutic Implications
Frontiers in Neuroscience, 2018 As people age, iron deposits in different areas of the brain may impair normal cognitive function and behavior. Abnormal iron metabolism generates hydroxyl radicals through the Fenton reaction, triggers oxidative stress reactions, damages cell lipids ...
Jun-Lin Liu +5 more
doaj +1 more source
Molecular Lysine Tweezers Counteract Aberrant Protein Aggregation. [PDF]
, 2019 Molecular tweezers (MTs) are supramolecular host molecules equipped with two aromatic pincers linked together by a spacer (Gakh, 2018). They are endowed with fascinating properties originating from their ability to hold guests between their aromatic ...
Bitan, Gal +4 more
core
Treatment for Dientamoeba fragilis: A Systematic Review and Meta-analysis
Infectious Diseases and TherapyIntroduction Dientamoeba fragilis (D. fragilis) is detected in stool tests of patients with gastrointestinal symptoms. Despite a debate over its pathogenicity, treatment is often prescribed, after excluding other reasons.
Nadav Baharav +3 more
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Prevention of Travelers' Diarrhea by Nonantibiotic Drugs [PDF]
, 2017 Travelers have resorted to a variety of drugs for prevention of diarrhea. No beneficial prophylactic effect has been confirmed for halogenated hydroxyquinolines, lactobacilli, antimotility drugs, ethacridine, and various other agents.
DuPont, Herbert L. +2 more
core
Estudio de la dermatitis por contacto alérgica mediante pruebas del parche, Serie Estándar Europea, en el Departamento de Dermatología del Hospital Universitario “Dr. José Eleuterio González”, UANL [PDF]
, 2008 Antecedentes: La dermatitis por contacto es causada por la exposición a sustancias que actúan como alergenos, irritantes primarios, o ambos. Las pruebas epicutáneas o del parche son útiles para su diagnóstico, sobre todo en casos con eczema crónico sin ...
Gutiérrez Terrazas, Teresa +3 more
core
A case-controlled study of Dientamoeba fragilis infections in children [PDF]
, 2011 Dientamoeba fragilis is a pathogenic protozoan parasite that is implicated as a cause of human diarrhoea. A case-controlled study was conducted to determine the clinical signs associated with D.
Banik, GR +5 more
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