Results 61 to 70 of about 4,021 (200)

Elemental bio-imaging : in situ analysis of trace elements in tissue by laser ablation-inductively coupled plasma-mass spectrometry [PDF]

, 2009
University of Technology, Sydney. Faculty of Science.Elemental bio-imaging is a new application of laser ablation - inductively coupled plasma - mass spectrometry (LA-ICP-MS) that determines in situ trace element concentrations in thin sections of ...
Hare, D
core  

Restoration of susceptibility to amikacin by 8-hydroxyquinoline analogs complexed to zinc.

PLoS ONE, 2019
Gram-negative pathogens resistant to amikacin and other aminoglycosides of clinical relevance usually harbor the 6'-N-acetyltransferase type Ib [AAC(6')-Ib], an enzyme that catalyzes inactivation of the antibiotic by acetylation using acetyl-CoA as donor
Jesus Magallon, Kevin Chiem, Tung Tran, Maria S Ramirez, Veronica Jimenez, Marcelo E Tolmasky   +5 more
doaj   +1 more source

From Yeast to Therapeutics: Modeling Neurodegenerative Diseases in Saccharomyces cerevisiae

Yeast, Volume 42, Issue 12, Page 283-302, December 2025.
Yeast plasmids expressing human Aβ‐42, α‐syn, htt, and TDP‐43. Their fate includes an equilibrium between the endocytic pathway and aggregates that potentially disrupt endocytosis, vesicular transport, vacuolar autophagy, and mitochondrial activity. ABSTRACT Here, we review the use of Saccharomyces cerevisiae as a powerful model organism for studying ...
Jose Ribamar Ferreira‐Junior, Vittoria de Lima Camandona, Mario H. Barros   +2 more
wiley   +1 more source

Monitoring Receptor Clustering by Aggregation‐Induced Emission

ChemPlusChem, Volume 90, Issue 11, November 10, 2025.
Receptor clustering induced by molecular recognition: AIE‐functionalized bisphosphonate receptors are embedded in a lipid bilayer. Upon addition of a cationic messenger, they undergo dimerization and send out a fluorescence signal. This study introduces a simple signal transduction system that mimics the receptor tyrosine kinase mechanism by employing ...
Robert Bekus, Kevin Rudolph, Steffen Riebe, Jens Voskuhl, Thomas Schrader   +4 more
wiley   +1 more source

Mechanochemische Methoden mit Anwendung in der Late‐Stage Modifizierung Pharmazeutisch Wirksamer Verbindungen

Angewandte Chemie, Volume 137, Issue 41, October 6, 2025.
Dieser Review diskutiert mechanochemische Strategien zur späten Modifizierung bioaktiver Wirkstoffe und bietet zugleich eine wertvolle Übersicht zur Auswahl geeigneter Substrate, um das pharmazeutische Potenzial neuer und bestehender (mechano)chemischer Verfahren zu evaluieren.
Johanna Templ, Lars Borchardt
wiley   +1 more source

A nuclear role for the respiratory enzyme CLK-1 in regulating mitochondrial stress responses and longevity [PDF]

, 2015
The coordinated regulation of mitochondrial and nuclear activities is essential for cellular respiration and its disruption leads to mitochondrial dysfunction, a hallmark of ageing.
A Dillin, A Wong, AJ Whitmarsh, Alan J. Whitmarsh, AM Nargund, B Lakowski, BN Marbois, C Frezza, C Frokjaer-Jensen, C Lopez-Otin, C Yee, CE Riera, D Cristina, DA Hall, E Owusu-Ansah, E Zeiser, EB Kayser, F Levavasseur, FY Chueh, G Sutendra, G Wright, Gino B. Poulin, H Miyadera, J Yun, JE Aldridge, JJ Ewbank, JM Matés, JM Van Raamsdonk, K Itoh, Kate Fisher, KJ Livak, L Papa, LA Sena, LV O’Keefe, M Bar-Peled, MB Jensen, N Jiang, Nicholas Rooney, NS Chandel, O Yogev, O Yogev, OK Mirzoeva, RH Houtkooper, Richard M. Monaghan, Robert G. Barnes, S Brenner, S Felkai, S Suzuki, SJ Lee, SP Whelan, SW Tait, T Jonassen, T Jonassen, Tereza Andreou, TJ Schulz, VN Kotiadis, W Yang, X Liu, Y Wang   +58 more
core   +2 more sources

Quantitative analysis of mixed lipid nanostructures in rat skin by HPLC-MS

Reviews in Analytical Chemistry
Liquid chromatography-mass spectrometry (LC-MS) is a very sensitive technique for determining small concentrations of drugs in fixed dose combinations or even those deposited in skin layers.
Al-Tannak Naser F., Abouelatta Samar M., Fahmy Nesma M., Hemdan Ahmed M.   +3 more
doaj   +1 more source

Mechanochemical Strategies Applied to the Late‐Stage Modifications of Pharmaceutically Active Compounds

Angewandte Chemie International Edition, Volume 64, Issue 41, October 6, 2025.
This review highlights mechanochemical strategies for the late‐stage modification of active pharmaceutical ingredients (APIs), providing a valuable resource for selecting substrates to evaluate the pharmaceutical potential of novel and existing (mechano)chemical protocols.
Johanna Templ, Lars Borchardt
wiley   +1 more source

Synthesis, Properties, and Typical Applications of MXene‐Based Heterostructure Materials

Advanced Materials Interfaces, Volume 12, Issue 19, October 6, 2025.
In recent years, MXene‐based heterostructure materials have achieved fruitful outcomes in multiple aspects. However, a comprehensive and systematic summary of MXene‐based heterostructures is still absent. This review summarizes the performance characteristics, synthesis methods, and the latest research progress of MXene heterostructures in several ...
Baoquan Xiao, Zelin Gao, Hengbiao Zhang, Jiantao Zhang, Shiyuan Wang, Gang Long, Shenghu Wei, Jixing Huang, Runqi Yao, Xingdong Jiang, Fei Ma, Xusheng Xia, Liyun Ding   +12 more
wiley   +1 more source

Loss‐of‐function polymorphisms in NQO1 are not associated with the development of subacute myelo‐optico‐neuropathy

Molecular Genetics & Genomic Medicine
Background Subacute myelo‐optico‐neuropathy (SMON) is a neurological disorder associated with the administration of clioquinol, particularly at very high doses. Although clioquinol has been used worldwide, there was an outbreak of SMON in the 1950s–1970s
Hideki Matsumoto, Hideo Sasai, Norio Kawamoto, Masato Katsuyama, Makoto Minamiyama, Satoshi Kuru, Toshiyuki Fukao, Hidenori Ohnishi, the SMON Research Group Members   +8 more
doaj   +1 more source