Results 41 to 50 of about 4,021 (200)
Contact Dermatitis, EarlyView.Nickel sensitisation in children decreased significantly over time, while dyes and isothiazolinones are emerging allergens. These findings underscore shifting exposure patterns and the need for continuous surveillance to guide effective patch testing and prevention strategies.
Mateja Starbek Zorko +2 more
wiley +1 more source
Future Journal of Pharmaceutical Sciences, 2020 Background The heterocyclic compounds are extremely important with wide array of synthetic, pharmaceutical, and industrial applications. Heterocyclic-containing compounds have been reported for their broad spectrum of biological activities including ...
Asmaa A. Mandour +3 more
doaj +1 more source
Nanoscale Reaction Vessels Designed for Synthesis of Copper-Drug Complexes Suitable for Preclinical Development. [PDF]
PLoS ONE, 2016 The development of copper-drug complexes (CDCs) is hindered due to their very poor aqueous solubility. Diethyldithiocarbamate (DDC) is the primary metabolite of disulfiram, an approved drug for alcoholism that is being repurposed for cancer.
Mohamed Wehbe +7 more
doaj +1 more source
Heliyon, 2021 Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the etiological agent for coronavirus disease 2019 (COVID-19), has resulted in an ongoing pandemic. Presently, there are no clinically approved drugs for COVID-19.
Omonike A. Olaleye +3 more
doaj +1 more source
Copper Overload Affects α‐Synuclein Clearance Mechanisms in a Parkinson's Disease In Vitro Model
Advanced Biology, Volume 10, Issue 5, May 2026.This study reveals that copper overload disrupts neuronal protein clearance, leading to the accumulation of α‐synuclein and its phosphorylated form (p‐S129). By blocking autophagy and impairing the ubiquitin–proteasome system, copper promotes toxic aggregation in dopaminergic cells.
Debora Musarò +4 more
wiley +1 more source
Clioquinol synergistically augments rescue by zinc supplementation in a mouse model of acrodermatitis enteropathica. [PDF]
PLoS ONE, 2013 BackgroundZinc deficiency due to poor nutrition or genetic mutations in zinc transporters is a global health problem and approaches to providing effective dietary zinc supplementation while avoiding potential toxic side effects are needed.Methods ...
Jim Geiser +5 more
doaj +1 more source
Computational Design of Azole Derivatives as Multifunctional Agents for Alzheimer's Disease
Applied Organometallic Chemistry, Volume 40, Issue 5, May 2026.A series of 19 azole derivatives were evaluated using bioinformatic tools and density functional theory in the context of multifunctional agents for Alzheimer's disease and were classified as potential antioxidant, distributor, and suppressor agents. ABSTRACT Alzheimer's disease (AD) is the most common form of dementia, characterized by multifactorial ...
Nicolás Puentes‐Díaz +5 more
wiley +1 more source
High‐Throughput Screening Reveals That CeeNU Acts as a New NLRP3 Inflammasome Inhibitor
MedComm, Volume 7, Issue 5, May 2026.We conducted a high‐throughput screen of 2747 FDA‐approved drugs to identify inhibitors of pyroptosis. We found that CeeNU significantly repressed NLRP3‐dependent IL‐1β release and GSDMD pore‐forming complex. We identified that the arginine 335 amino acid of the NACHT domain of NLRP3 is the critical point for human NLRP3 and CeeNU interaction and ...
Sen‐Lin Ji +11 more
wiley +1 more source
β-Amyloid peptides induce mitochondrial dysfunction and oxidative stress in astrocytes and death of neurons through activation of NADPH oxidase [PDF]
, 2004 β-Amyloid (βA) peptide is strongly implicated in the neurodegeneration underlying Alzheimer's disease, but the mechanisms of neurotoxicity remain controversial. This study establishes a central role for oxidative stress by the activation of NADPH oxidase
Abramov, A.Y. +2 more
core
Contact Sensitization in Adults With Atopic Dermatitis: A 21‐Year Single‐Center Tertiary Experience
Contact Dermatitis, Volume 94, Issue 5, Page 465-474, May 2026.A graphical abstract has been included as supplemental material. ABSTRACT Background Atopic dermatitis is a common chronic inflammatory skin condition. Data on contact sensitization in adults with atopic dermatitis remain limited. Objectives To investigate the prevalence of contact sensitization in adults with and without AD: Patients/Methods A ...
Francesca Caroppo +5 more
wiley +1 more source