Results 11 to 20 of about 3,979 (194)

Metal chaperones prevent zinc-mediated cognitive decline [PDF]

Neurobiology of Disease, 2015
Zinc transporter-3 (ZnT3) protein is responsible for loading zinc into presynaptic vesicles and consequently controls the availability of zinc at the glutamatergic synapse.
Paul A. Adlard, Jacqui Parncutt, Varsha Lal, Simon James, Dominic Hare, Philip Doble, David I. Finkelstein, Ashley I. Bush   +7 more
doaj   +2 more sources

Navigating the Chemical Space of Multitarget-Directed Ligands: From Hybrids to Fragments in Alzheimer’s Disease [PDF]

Molecules, 2016
Multitarget drug discovery is one of the hottest topics and most active fields in the search for new molecules against Alzheimer’s disease (AD). Over the last 20 years, many promising multitarget-directed ligands (MTDLs) have been identified and ...
Federica Prati, Andrea Cavalli, Maria Laura Bolognesi   +2 more
doaj   +5 more sources

Early Clinical Response of a Large Amebic Liver Abscess to Eravacycline Prior to Metronidazole Initiation: A Case Report. [PDF]

Case Rep Infect Dis
Entamoeba histolytica is an amebic protozoan that is often asymptomatic, with many patients being asymptomatic carriers. However, 10 percent of cases manifest with amebic dysentery and, less commonly, amebic liver abscesses. Amebic liver abscesses are the most common extraintestinal manifestation of E. histolytica.
Anthony JA, Robinson A, Pedroza L.
europepmc   +2 more sources

Mitigating Molecular Aggregation in Drug Discovery With Predictive Insights From Explainable AI. [PDF]

Angew Chem Int Ed Engl
In this work, MEGAN, our explainable AI model, is applied to predict small colloidally aggregating molecules (SCAMs), a significant source of false positives in drug discovery. MEGAN provides interpretable predictions and proposes structurally similar, non‐aggregating alternative molecules.
Sturm H, Teufel J, Isfeld KA, Friederich P, Davis RL.   +4 more
europepmc   +3 more sources

Clioquinol as a new therapy in epilepsy: From preclinical evidence to a proof-of-concept clinical study. [PDF]

Epilepsia
Abstract Objective Drug‐resistant epilepsy (DRE) affects >25 million people worldwide and is often associated with neuroinflammation. Increasing evidence links deficiency or malfunctioning of the enzyme phosphoglycerate dehydrogenase (PHGDH), which converts 3‐phosphoglycerate to generate serine and the neurotransmitter glycine, with (drug‐resistant ...
Thevissen K, Ny A, Copmans D, Tits J, Kamata K, Gielis E, Longin K, Sourbron J, Thergarajan P, Tan TH, Ali I, Jones NC, O'Brien TJ, Monif M, Semple BD, Germeys C, Frizzi B, Minniti V, Perrone S, Linster CL, Elia I, Van Den Bosch L, Cammue BPA, Voet A, Lagae L, de Witte P.   +25 more
europepmc   +2 more sources

Therapeutic Effect of Ultrasound Combined With Porous Lipid Clioquinol/PLGA Microbubbles on Ferroptosis in HL-1 Cardiac Cell Induced by Isoproterenol Attack

Frontiers in Pharmacology, 2022
In recent years, studies have shown a close relationship between cardiomyocyte death and ferroptosis. Clioquinol (CQ) can inhibit ferroptosis. Porous lipid-poly (lactic-co-glycolic acid) (PLGA) microbubbles (MBs) were prepared by double emulsification ...
Nana Li, Lei Dong, Yuanyuan Shen, Yongling Wang, Liansheng Chang, Hongwei Wu, Yuqiao Chang, Menghao Li, Dan Li, Zhaoyi Li, Mei He, Cheng Li, Yao Wei, Haiqin Xie, Feng Wang   +14 more
doaj   +1 more source

In vitro selective growth-inhibitory effect of 8-hydroxyquinoline on Clostridium perfringens versus Bifidobacteria in a medium containing chicken ileal digesta [PDF]

, 2016
Clostridium perfringens-induced necrotic enteritis is generally controlled by antibiotics. However, because of increasing antibiotic resistance, other antibacterial agents are required, preferably ones that do not affect the beneficial intestinal ...
Hovorkova, Petra, Kokoska, Ladislav, Skrivanova, Eva, Van Immerseel, Filip   +3 more
core   +7 more sources

The effects of clioquinol in morphogenesis, cell membrane and ion homeostasis in Candida albicans

BMC Microbiology, 2020
Background Candida albicans is the most prevalent opportunistic fungal pathogen. Development of antifungals with novel targets is necessary for limitations of current antifungal agents and the emergence of drug resistance.
Zimeng You, Chaoliang Zhang, Yuping Ran
doaj   +1 more source

Hydroxychloroquine Does Not Function as a Direct Zinc Ionophore

Pharmaceutics, 2022
Drug-mediated correction of abnormal biological zinc homeostasis could provide new routes to treating neurodegeneration, cancer, and viral infections.
Oisín N. Kavanagh, Shayon Bhattacharya, Luke Marchetti, Robert Elmes, Finbarr O’Sullivan, John P. Farragher, Shane Robinson, Damien Thompson, Gavin M. Walker   +8 more
doaj   +1 more source

Antibacterial and Antibiofilm Activity of 8-Hydroxyquinoline Derivatives Against Mycobacterium and Staphylococcus Species. [PDF]

Chem Biodivers
Synthesis of 8‐hydroxyquinoline derivatives (QD 1‐12) from different analogues of 8‐hydroxyquinoline (HQ 1‐4). The derivatives and parent compounds were evaluated for antibacterial and antibiofilm activity against Mycobacterium tuberculosis, Mycobacterium smegmatis, methicillin‐resistant Staphylococcus aureus and methicillin‐sensitive Staphylococcus ...
Lall N, Kok AM, Oosthuizen CB, Verma S, Chassagne F, Vo PH, Ho KV, Lin CH, Quave CL, Twilley D.   +9 more
europepmc   +2 more sources