Navigating the Chemical Space of Multitarget-Directed Ligands: From Hybrids to Fragments in Alzheimer’s Disease [PDF]
Molecules, 2016 Multitarget drug discovery is one of the hottest topics and most active fields in the search for new molecules against Alzheimer’s disease (AD). Over the last 20 years, many promising multitarget-directed ligands (MTDLs) have been identified and ...
Federica Prati +2 more
doaj +5 more sources
Metal chaperones prevent zinc-mediated cognitive decline [PDF]
Neurobiology of Disease, 2015 Zinc transporter-3 (ZnT3) protein is responsible for loading zinc into presynaptic vesicles and consequently controls the availability of zinc at the glutamatergic synapse.
Paul A. Adlard +7 more
doaj +2 more sources
Early Clinical Response of a Large Amebic Liver Abscess to Eravacycline Prior to Metronidazole Initiation: A Case Report. [PDF]
Case Rep Infect DisEntamoeba histolytica is an amebic protozoan that is often asymptomatic, with many patients being asymptomatic carriers. However, 10 percent of cases manifest with amebic dysentery and, less commonly, amebic liver abscesses. Amebic liver abscesses are the most common extraintestinal manifestation of E. histolytica.
Anthony JA, Robinson A, Pedroza L.
europepmc +2 more sources
Clioquinol as a new therapy in epilepsy: From preclinical evidence to a proof-of-concept clinical study. [PDF]
EpilepsiaAbstract Objective Drug‐resistant epilepsy (DRE) affects >25 million people worldwide and is often associated with neuroinflammation. Increasing evidence links deficiency or malfunctioning of the enzyme phosphoglycerate dehydrogenase (PHGDH), which converts 3‐phosphoglycerate to generate serine and the neurotransmitter glycine, with (drug‐resistant ...
Thevissen K +25 more
europepmc +2 more sources
Mitigating Molecular Aggregation in Drug Discovery With Predictive Insights From Explainable AI. [PDF]
Angew Chem Int Ed EnglIn this work, MEGAN, our explainable AI model, is applied to predict small colloidally aggregating molecules (SCAMs), a significant source of false positives in drug discovery. MEGAN provides interpretable predictions and proposes structurally similar, non‐aggregating alternative molecules.
Sturm H +4 more
europepmc +2 more sources
Frontiers in Pharmacology, 2022 In recent years, studies have shown a close relationship between cardiomyocyte death and ferroptosis. Clioquinol (CQ) can inhibit ferroptosis. Porous lipid-poly (lactic-co-glycolic acid) (PLGA) microbubbles (MBs) were prepared by double emulsification ...
Nana Li +14 more
doaj +1 more source
The effects of clioquinol in morphogenesis, cell membrane and ion homeostasis in Candida albicans
BMC Microbiology, 2020 Background Candida albicans is the most prevalent opportunistic fungal pathogen. Development of antifungals with novel targets is necessary for limitations of current antifungal agents and the emergence of drug resistance.
Zimeng You, Chaoliang Zhang, Yuping Ran
doaj +1 more source
Hydroxychloroquine Does Not Function as a Direct Zinc Ionophore
Pharmaceutics, 2022 Drug-mediated correction of abnormal biological zinc homeostasis could provide new routes to treating neurodegeneration, cancer, and viral infections.
Oisín N. Kavanagh +8 more
doaj +1 more source
In vitro selective growth-inhibitory effect of 8-hydroxyquinoline on Clostridium perfringens versus Bifidobacteria in a medium containing chicken ileal digesta [PDF]
, 2016 Clostridium perfringens-induced necrotic enteritis is generally controlled by antibiotics. However, because of increasing antibiotic resistance, other antibacterial agents are required, preferably ones that do not affect the beneficial intestinal ...
Hovorkova, Petra +3 more
core +7 more sources
The pharmacological perturbation of brain zinc impairs BDNF-related signaling and the cognitive performances of young mice. [PDF]
, 2018 Zinc (Zn2+) is a pleiotropic modulator of the neuronal and brain activity. The disruption of intraneuronal Zn2+ levels triggers neurotoxic processes and affects neuronal functioning.
Bomba, Manuela +13 more
core +3 more sources