The nuclear receptor genes HR3 and E75 are required for the circadian rhythm in a primitive insect. [PDF]
PLoS ONE, 2014 Insect circadian rhythms are generated by a circadian clock consisting of transcriptional/translational feedback loops, in which CYCLE and CLOCK are the key elements in activating the transcription of various clock genes such as timeless (tim) and period
Yuichi Kamae +3 more
doaj +5 more sources
Altered circadian expression of clock genes and clock-regulatory epigenetic modifiers in saliva of children with fetal alcohol spectrum disorders [PDF]
Scientific ReportsPrenatal alcohol-exposed (AE) infants and children often demonstrate disrupted sleep patterns, including more frequent awakenings, reduced total sleep time, and more night-to-night sleep variability.
Ujjal Das +6 more
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Thyroxine differentially modulates the peripheral clock: lessons from the human hair follicle [PDF]
, 2015 The human hair follicle (HF) exhibits peripheral clock activity, with knock-down of clock genes (BMAL1 and PER1) prolonging active hair growth (anagen) and increasing pigmentation.
Farjo, Bessam +4 more
core +23 more sources
Rhythmic Clock Gene Expression in Atlantic Salmon Parr Brain
Frontiers in Physiology, 2021 To better understand the complexity of clock genes in salmonids, a taxon with an additional whole genome duplication, an analysis was performed to identify and classify gene family members (clock, arntl, period, cryptochrome, nr1d, ror, and csnk1).
Charlotte M. Bolton +4 more
doaj +1 more source
A survey of genomic studies supports association of circadian clock genes with bipolar disorder spectrum illnesses and lithium response. [PDF]
PLoS ONE, 2012 Circadian rhythm abnormalities in bipolar disorder (BD) have led to a search for genetic abnormalities in circadian "clock genes" associated with BD. However, no significant clock gene findings have emerged from genome-wide association studies (GWAS). At
Michael J McCarthy +3 more
doaj +1 more source
Cells, 2021 The circadian clock drives time-specific gene expression, enabling biological processes to be temporally controlled. Plants that conduct crassulacean acid metabolism (CAM) photosynthesis represent an interesting case of circadian regulation of gene ...
Robert C. Moseley +4 more
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C-terminal binding protein (CtBP) activates the expression of E-box clock genes with CLOCK/CYCLE in Drosophila. [PDF]
PLoS ONE, 2013 In Drosophila, CLOCK/CYCLE heterodimer (CLK/CYC) is the primary activator of circadian clock genes that contain the E-box sequence in their promoter regions (hereafter referred to as "E-box clock genes").
Taichi Q Itoh +2 more
doaj +1 more source
Ensemble Methods for Identifying RNA Operons and Regulons in the Clock Network of Neurospora Crassa
IEEE Access, 2022 With both light entrainment data (L/D) and free running data in the dark (D/D), Variable Topology Ensemble Methods (VTENS) were used to reconstruct the entire genome-scale clock network involving 3380 genes and their products under the hypothesis that ...
Ahmad M. Al-Omari +5 more
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Feeding period restriction alters the expression of peripheral circadian rhythm genes without changing body weight in mice. [PDF]
PLoS ONE, 2012 Accumulating evidence suggests that the circadian clock is closely associated with metabolic regulation. However, whether an impaired circadian clock is a direct cause of metabolic dysregulation such as body weight gain is not clearly understood. In this
Hagoon Jang +5 more
doaj +1 more source
Circadian Rhythms in the CNS and Peripheral Clock Disorders: The Circadian Clock and Hyperlipidemia
Journal of Pharmacological Sciences, 2007 A circadian clock controls various physiological and behavioral rhythms. In mammals, a master circadian clock exists in the suprachiasmatic nucleus of the hypothalamus, and slave oscillators can be found in most tissues.
Takashi Kudo +2 more
doaj +1 more source