Results 111 to 120 of about 159,356 (284)

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Constructing a Model Using Clock‐Related lncRNAs for Predicting the Tumor Microenvironment of Gliomas

Brain and Behavior
Purpose Circadian locomotor output cycles kaput (CLOCK) and its related genes play important roles in cellular functions. This study aims to construct a predictive model for CLOCK‐related genes and identify lncRNAs that may influence Tumor ...
Mingjie Gong, Chengfa Sun, Zhenhua Shi, Junxiang Wang, Weiwei Zhai, Zhengquan Yu   +5 more
doaj   +1 more source

Rejuvenation by cell reprogramming: A new horizon in gerontology [PDF]

, 2018
The discovery of animal cloning and subsequent development of cell reprogramming technology were quantum leaps as they led to the achievement of rejuvenation by cell reprogramming and the emerging view that aging is a reversible epigenetic process. Here,
Brown, Oscar Alfredo, Canatelli Mallat, Martina, Chiavellini, Priscila, Goya, Rodolfo Gustavo, Hereñú, Claudia Beatriz, Lehmann, Marianne   +5 more
core   +2 more sources

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

An Overview of the Polymorphisms of Circadian Genes Associated With Endocrine Cancer

Frontiers in Endocrinology, 2019
A major consequence of the world industrialized lifestyle is the increasing period of unnatural light in environments during the day and artificial lighting at night.
Sonia Morales-Santana, Santiago Morell, Josefa Leon, Angel Carazo-Gallego, Jose C. Jimenez-Lopez, Jose C. Jimenez-Lopez, María Morell   +6 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Circadian rhythms and hormonal homeostasis: Pathophysiological implications [PDF]

, 2017
Over recent years, a deeper comprehension of the molecular mechanisms that control biological clocks and circadian rhythms has been achieved. In fact, many studies have contributed to unravelling the importance of the molecular clock for the regulation ...
Bruscalupi, Giovannella, Gnocchi, Davide
core   +2 more sources

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

A network of pro-inflammatory genes repressed by clock signalling in bronchial epithelium

ERJ Open Research
Background Circadian rhythms are biological cycles that regulate various physiological processes, including immune responses, tissue repair and oxidative stress. Previous studies indicated a role for distorted circadian signalling in COPD.
Xiaopeng Li, Karthi Srikanthan, Siti Farah Rahmawati, Dirk-Jan Slebos, Pallav L. Shah, Philip J. Johnson, Loes E.M. Kistemaker, Anika Nagelkerke, Reinoud Gosens   +8 more
doaj   +1 more source

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source