Results 31 to 40 of about 159,356 (284)
Clock genes, pancreatic function, and diabetes [PDF]
Trends in Molecular Medicine, 2014 Circadian physiology is responsible for the temporal regulation of metabolism to optimize energy homeostasis throughout the day. Disturbances in the light/dark cycle, sleep/wake schedule, or feeding/activity behavior can affect the circadian function of the clocks located in the brain and peripheral tissues.
Vieira, Elaine +2 more
openaire +3 more sources
Regulated DNA Methylation and the Circadian Clock: Implications in Cancer
Biology, 2014 Since the cloning and discovery of DNA methyltransferases (DNMT), there has been a growing interest in DNA methylation, its role as an epigenetic modification, how it is established and removed, along with the implications in development and disease.
Tammy M. Joska +2 more
doaj +1 more source
Circadian clocks and breast cancer [PDF]
, 2016 Circadian clocks respond to environmental time cues to coordinate 24-hour oscillations in almost every tissue of the body. In the breast, circadian clocks regulate the rhythmic expression of numerous genes.
Blakeman, V +3 more
core +2 more sources
Integrative Cancer Therapies, 2009 Period genes ( Per2, Per1) are essential circadian clock genes. They also function as negative growth regulators. Per2 mutant mice show de novo and radiation-induced epithelial hyperplasia, tumors, and an abnormal DNA damage response. Human tumors show Period gene mutations or decreased expression.
Patricia A, Wood +2 more
openaire +2 more sources
Body weight, metabolism and clock genes [PDF]
Diabetology & Metabolic Syndrome, 2010 Biological rhythms are present in the lives of almost all organisms ranging from plants to more evolved creatures. These oscillations allow the anticipation of many physiological and behavioral mechanisms thus enabling coordination of rhythms in a timely manner, adaption to environmental changes and more efficient organization of the cellular processes
Zanquetta Melissa M +3 more
openaire +3 more sources
PLoS ONE, 2019 The use of emerging tobacco products, such as waterpipe or hookah and electronic cigarettes (e-cigs), has gained significant popularity and are promoted as safer alternatives to conventional cigarettes.
Naushad Ahmad Khan +5 more
doaj +1 more source
Transcription of Clock Genes in Medulloblastoma. [PDF]
Cancers (Basel)We investigated the transcription of circadian clock genes in publicly available datasets of gene expression in medulloblastoma (MB) tissues using the R2 Genomics Analysis and Visualization Platform. Differential expression of the core clock genes among the four consensus subgroups of MB (defined in 2012 as Group 3, Group 4, the SHH group, and the WNT ...
Vriend J, Glogowska A.
europepmc +3 more sources
Associations of clock genes polymorphisms with soft tissue sarcoma susceptibility and prognosis [PDF]
, 2018 BACKGROUND: Dysfunction of the circadian clock and polymorphisms of some circadian genes have been linked to cancer development and progression. We investigated the relationship between circadian genes germline variation and susceptibility or prognosis ...
Benna, Clara +6 more
core +2 more sources
Clock genes running amok [PDF]
EMBO reports, 2007 The rotation of the earth exposes its inhabitants to a daily rhythm of changes in temperature and light intensity. All species are well adapted to this phenomenon, as they have endogenous clocks that generate internal rhythms with a periodicity of approximately 24 hours.
Stéphanie, Perreau-Lenz +2 more
openaire +2 more sources
Journal of Circadian Rhythms, 2018 In mammals, circadian rhythmicity is sustained via a transcriptional/translational feedback loop referred to as the canonical molecular circadian clock.
Abdullah Mashhour +5 more
doaj +1 more source