Results 51 to 60 of about 4,936 (166)

Tissue-specific differential induction of duplicated fatty acid-binding protein genes by the peroxisome proliferator, clofibrate, in zebrafish (Danio rerio)

open access: yes, 2012
Background: Force, Lynch and Conery proposed the duplication-degeneration-complementation (DDC) model in which partitioning of ancestral functions (subfunctionalization) and acquisition of novel functions (neofunctionalization) were the two primary ...
Lall, Santosh P.   +3 more
core   +1 more source

Assessment of Preclinical Liver and Skeletal Muscle Biomarkers Following Clofibrate Administration in Wistar Rats

open access: yes, 2017
Clofibrate is a known rodent hepatotoxicant classically associated with hepatocellular hypertrophy and increased serum activities of cellular alanine aminotransferase/aspartate aminotransferase (ALT/AST) in the absence of microscopic hepatocellular ...
Balázs Bánfai   +6 more
core   +1 more source

Comparison of the efficacy of Clofibrate with Phenobarbital in decreasing neonatal hyperbilirubinemia [PDF]

open access: yes
Background: Hyperbilirubinemia is a common problem in newborn infants. It can progress to kernicterus in severe forms, unless an intervention is initiated.
احدی, عادل   +4 more
core  

Indentification of β-oxidation enzymes among peroxisomal polypeptides Increase in Coomassie blue-stainable protein after clofibrate treatment

open access: yes, 1982
Peroxisomes contain enzymes catalyzing the β-oxidation of fatty acids, which have been purified and partially characterized. Hypolipidemic drugs, including clofibrate, cause a marked proliferation of peroxisomes and a striking increase in the activity of
Fujiki, Yukio   +7 more
core   +1 more source

The effect of clofibrate on decreasing serum Bilirubin in healthy term neonates under home phototherapy

open access: yes, 2010
Objective: this study was designed to determine the effect of clofibrate on neonatal uncomplicated jaundice treated with home phototherapy. Methods: This clinical trial study was performed on 60 newborns with jaundice that received home phototherapy ...
Mortazavi, Zhaleh   +3 more
core  

Synthesis and Biological Evaluation of New Clofibrate Analogues as Potential PPARa Agonists

open access: yes, 2005
Clofibrate is a lipid-profile modifying agent belonging to the fibrate class of drugs. Fibrates are known to exhibit their beneficial effects by activating peroxisome proliferator-activated receptor-a (PPARa) and used in the treatment of dyslipidemia ...
SCIARRONI A. F   +7 more
core   +1 more source

Long-term trial with Colestipol plus clofibrate in familial hypercholesterolemia

open access: yes, 1978
Twenty subjects with familial hypercholesterolemia (12 Type IIa and 8 Type IIb), previously treated with Colestipol for 16 months, were subjected to therapy with Colestipol (15 g/day) + clofibrate (2 g/day) for 15 months.
G. Baggio   +6 more
core  

Effects of clofibrate treatment on arginine-induced insulin secretion in endogenous hypertriglyceridemia

open access: yes, 1976
Arginine-induced insulin secretion was evaluated in 13 patients with endogenous hypertriglyceridemia (Fredrickson's Type IV) before and after a two-month period of Clofibrate therapy.
A. Tiengo   +4 more
core  

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