Results 41 to 50 of about 8,788 (204)

AS601245, an Anti-Inflammatory JNK Inhibitor, and Clofibrate Have a Synergistic Effect in Inducing Cell Responses and in Affecting the Gene Expression Profile in CaCo-2 Colon Cancer Cells

PPAR Research, 2012
PPARαs are nuclear receptors highly expressed in colon cells. They can be activated by the fibrates (clofibrate, ciprofibrate etc.) used to treat hyperlipidemia.
Angelo Cerbone, Cristina Toaldo, Stefania Pizzimenti, Piergiorgio Pettazzoni, Chiara Dianzani, Rosalba Minelli, Eric Ciamporcero, Guglielmo Roma, Mario Umberto Dianzani, Roberto Canaparo, Carlo Ferretti, Giuseppina Barrera   +11 more
doaj   +1 more source

The Mechanistic Role of PPARγ in Wound Healing

PPAR Research, Volume 2026, Issue 1, 2026.
The receptor known as peroxisome proliferator‐activated receptor gamma (PPARγ) is crucial for effective wound healing, and recent progress has given a deeper understanding of its complex functions. As a biological switch, PPARγ regulates the immune response by shifting macrophages from promoting inflammation to supporting tissue regeneration, while ...
Zhaojun Wang, Kaixing Jia, Wei Wang, Xiaolong Du, Yueyan Wu, Jianan Wang, John P. Vanden Heuvel   +6 more
wiley   +1 more source

PPAR-alpha: a novel target in pancreatic cancer [PDF]

, 2015
Background: Current targeted therapies in pancreatic cancer have been ineffective. The tumor stroma, including intra- and peri-tumoral inflammation and fibrosis, is increasingly implicated in pancreatic cancer.
Hua, Alexander Mach
core   +1 more source

Effects of human pharmaceuticals on cytotoxicity, EROD activity and ROS production in fish hepatocytes. [PDF]

, 2004
Pharmaceuticals are found in the aquatic environment but their potential effects on non-target species like fish remain unknown. This in vitro study is a first approach in the toxicity assessment of human drugs on fish.
Aït-Aïssa, S., Casellas, C., Gomez, E., Laville, N., Porcher, J. M.   +4 more
core   +3 more sources

Icariin Is A PPARα Activator Inducing Lipid Metabolic Gene Expression in Mice

Molecules, 2014
Icariin is effective in the treatment of hyperlipidemia. To understand the effect of icariin on lipid metabolism, effects of icariin on PPARα and its target genes were investigated.
Yuan-Fu Lu, Yun-Yan Xu, Feng Jin, Qin Wu, Jing-Shan Shi, Jie Liu   +5 more
doaj   +1 more source

A Cell‐Penetrating Scorpion Venom Peptide Disrupts the HSP90β‐PPARα Interaction to Ameliorate Metabolic Dysfunction‐Associated Steatotic Liver Disease

iMetaMed, Volume 1, Issue 2, December 2025.
In MASLD, increased HSP90β interacts with PPARα, thereby inhibiting PPARα activation via the inhibition of its nuclear translocation. BmK Tx‐2, a cell‐penetrating peptide from Buthus martensii Karsch scorpion venom, enters hepatocytes via macropinocytosis and escapes endosomes to bind HSP90β.
Erjin Xu, Wuguang Lu, Yonggen Chen, Ming Sang, Jiao Chen, Xueting Cai, Wenhao Xu, Yuxin Zhang, Zhiheng Wang, Feng Zhang, Peng Cao   +10 more
wiley   +1 more source

The Effect of Purgative Manna and Clofibrate on Neonatal Unconjugated Hyperbilirubinemia

Acta Medica Iranica, 2019
This study was conducted to determine the effect of purgative Manna and clofibrate on unconjugated hyperbilirubinemia of term neonates. In this randomized clinical trial study, sixty neonates suffering from unconjugated hyperbilirubinemia were evaluated.
Abolfazl Mahyar, Shahrokh Mehrpisheh, Bahman Khajeh, Parviz Ayazi, Sonia Oveisi, Shifteh Mahyar, Shiva Esmaeili   +6 more
doaj   +1 more source

Adsorption of two pesticides on a clay surface: a theoretical study [PDF]

, 2012
The contamination of water resources with many organic xenobiotic compounds poses a challenge to environmental sciences and technologies [1]. Although in many cases these contaminants are present only in small concentrations, the large variety of such ...
Carvalho, A. J. Palace, Dordio, A. V., Ramalho, J.P. Prates   +2 more
core  

A review on promising natural agents effective on hyperlipidemia. [PDF]

, 2015
Hyperlipidemia is a prevalent disease and a major component of the metabolic syndrome resulting from various factors. This disease increases morbidity and mortality when combined with other prevalent diseases such as diabetes mellitus, hypertension, and ...
Bahmani, M., Mirhoseini, M., Rafieian-Kopaei, M., Sedighi, M., Shahinfard, N., Shirzad, H.   +5 more
core   +2 more sources

A quantitative analysis of fine structure and drug metabolism in livers of clofibrate-treated young adult and retired breeder rats

Journal of Lipid Research, 1978
The effects of clofibrate on the fine structure and drug-metabolizing capacity of livers of normolipidemic young adult virgin (YA) and hypercholesterolemic retired breeder (RB) male rats were measured by morphometric and biochemical procedures.
L E Anthony, D L Schmucker, J S Mooney, A L Jones, MD   +3 more
doaj   +1 more source