Results 21 to 30 of about 8,788 (204)

Involvement of Inflammatory Cytokines in Antiarrhythmic Effects of Clofibrate in Ouabain-Induced Arrhythmia in Isolated Rat Atria

Advances in Pharmacological Sciences, 2016
Considering the cardioprotective and anti-inflammatory properties of clofibrate, the aim of the present experiment was to investigate the involvement of local and systemic inflammatory cytokines in possible antiarrhythmic effects of clofibrate in ouabain-
Somayeh Moradi, Vahid Nikoui, Muhammad Imran Khan, Shayan Amiri, Farahnaz Jazaeri, Azam Bakhtiarian   +5 more
doaj   +1 more source

HEPATOPROTECTIVE ACTION OF Artemisia pallens lEAVES ON Pangasius Sp. TREATED WITH CHLOFIBRATE AND PHENOL [PDF]

Biotechnologia Acta, 2021
Aim. The key motive was to investigate the toxicological impact of clofibrate and phenol prescribed under human medicine, having potential in water and sediments contamination via input from sewage treatment plants as active pharmaceutical compounds ...
B. Vijaya Geetha, K S. Shreenidhi, P. Priya Vadhana, N. Purnima, A. Rashminiza, S. Sneha   +4 more
doaj   +1 more source

Tissue-specific differential induction of duplicated fatty acid-binding protein genes by the peroxisome proliferator, clofibrate, in zebrafish (Danio rerio)

BMC Evolutionary Biology, 2012
Background Force, Lynch and Conery proposed the duplication-degeneration-complementation (DDC) model in which partitioning of ancestral functions (subfunctionalization) and acquisition of novel functions (neofunctionalization) were the two primary ...
Venkatachalam Ananda B, Lall Santosh P, Denovan-Wright Eileen M, Wright Jonathan M   +3 more
doaj   +1 more source

Induction of Peroxisomal β-Oxidation as a Critical Mechanism for Ethanol-Induced Hepatic Triglyceride Accumulation. [PDF]

FASEB Bioadv
Prolonged fasting and fibrate treatment induce peroxisomal β‐oxidation and lead to excessive generation of hydrogen peroxide, which stimulates ethanol metabolism and significantly increases the formation of acetaldehyde; further oxidation of acetaldehyde into acetate remarkably elevates the mitochondrial ratio of NADH/NAD+ and causes feedback ...
Zhang Y, Zhang W, Li Y, Yao H, Wang Y, Zhang X, Zeng J.   +6 more
europepmc   +2 more sources

Fatty Liver Is Associated with Transcriptional Downregulation of Stearoyl-CoA Desaturase and Impaired Protein Dimerization [PDF]

, 2013
AIMS AND METHODS: We evaluated the modulation of liver stearoyl-CoA desaturase-1 (Scd1) by dietary factors and insulin resistance (IR) in two experimental models of high-fat diet (HFD)-induced nonalcoholic fatty liver disease (NAFLD).
Burgueño, Adriana Laura, Fernandez Gianotti, Tomas, Gonzales Mansilla, Noelia Luz, Pirola, Carlos Jose, Sookoian, Silvia Cristina   +4 more
core   +2 more sources

Stimulation of cardiac cardiolipin biosynthesis by PPARα activation

Journal of Lipid Research, 2004
The role of peroxisome proliferator-activated receptor α (PPARα)-stimulated phospholipase A2 (PLA2) in cardiac mitochondrial cardiolipin (CL) biosynthesis was examined in both in vivo and in vitro models. Treatment of rat heart H9c2 cells with clofibrate
Yan J. Jiang, Biao Lu, Fred Y. Xu, Jennifer Gartshore, William A. Taylor, Andrew J. Halayko, Frank J. Gonzalez, Jun Takasaki, Patrick C. Choy, Grant M. Hatch   +9 more
doaj   +1 more source

Comparing the effect of clofibrate and phenobarbital on the newborns with hyperbilirubinemia [PDF]

, 2013
The aim of treating hyperbilirubinemia is preventing the serum bilirubin to reach neurotoxic levels, which is done by phototherapy or blood transfusion. However, pharmacological treatments still remain vague.
Hamidi, Majid, Mesripour, Azadeh, Zamanzad, Behnam   +2 more
core   +4 more sources

Malic enzyme gene in chick embryo hepatocytes in culture: clofibrate regulates responsiveness to triiodothyronine

Journal of Lipid Research, 1996
In chick embryo hepatocytes, triiodothyronine (T3) causes a 30- to 40-fold increase in malic enzyme activity when added between 1 and 3 days, but has no effect when added between 5 and 7 days in culture.
T L Carlisle, C Roncero, C el Khadir-Mounier, D C Thurmond, A G Goodridge   +4 more
doaj   +1 more source

Treatment with PPARα Agonist Clofibrate Inhibits the Transcription and Activation of SREBPs and Reduces Triglyceride and Cholesterol Levels in Liver of Broiler Chickens

PPAR Research, 2015
PPARα agonist clofibrate reduces cholesterol and fatty acid concentrations in rodent liver by an inhibition of SREBP-dependent gene expression. In present study we investigated the regulation mechanisms of the triglyceride- and cholesterol-lowering ...
Lijun Zhang, Chunyan Li, Fang Wang, Shenghua Zhou, Mingjun Shangguan, Lina Xue, Bianying Zhang, Fuxiang Ding, Dequan Hui, Aihua Liang, Dongchang He   +10 more
doaj   +1 more source

Pharmacological manipulation of arachidonic acid-epoxygenase results in divergent effects on renal damage

Frontiers in Pharmacology, 2014
Kidney damage is markedly accelerated by high-salt (HS) intake in stroke-prone spontaneously hypertensive rats (SHRSP). Epoxyeicosatrienoic acids (EETs) are epoxygenase products of arachidonic acid which possess vasodepressor, natriuretic and anti ...
Jing eLi, Charles T. Stier, Praveen N. Chander, Vijaya L. Manthati, John R. Falck, Mairead A. Carroll   +5 more
doaj   +1 more source