Results 21 to 30 of about 4,936 (166)

Clofibrate Treatment Decreases Inflammation and Reverses Myocardial Infarction-Induced Remodelation in a Rodent Experimental Model

, 2019
Myocardial infarction (MI) initiates an inflammatory response that promotes both beneficial and deleterious effects. The early response helps the myocardium to remove damaged tissue; however, a prolonged later response brings cardiac remodeling ...
Elizabeth Soria-Castro, Juan C. Torres-Narváez, Luz G. Cervantes-Pérez, Jesús Vargas-Barrón, Juan C. Torres-Narváez, Francisco J. Roldán, Luz Ibarra-Lara, Gustavo Pastelín-Hernández, Natalia Pavón, Luz G. Cervantes-Pérez, María Sánchez-Aguilar, Alicia Sánchez-Mendoza, Francisco J. Roldán   +12 more
core   +1 more source

Stimulation of Bile Acid Biosynthesis by Clofibrate [PDF]

, 1982
The hypocholesterolemic effect of clofibrate (ethyl p-chlorophenoxyisobutyrate) was investigated in rats under conditions of severe hypercholesterolemia produced by administering relatively large amounts of cholesterol.
山嵜, フミ惠, 林, 秀徳, 福山, 潔   +2 more
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Therapie des Xanthoma disseminatum – eine systematische Literaturrecherche

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, Volume 23, Issue 9, Page 1061-1070, September 2025.
Zusammenfassung Das Xanthoma disseminatum ist eine seltene Erkrankung aus dem Spektrum der Nicht‐Langerhans‐Zell‐Histiozytosen, welche in drei Gruppen eingeteilt werden kann und teilweise mit einer Systembeteiligung einhergeht. Da die Erkrankung selten ist, fehlen standardisierte Therapierichtlinien, wodurch die Behandlung im klinischen Alltag ...
Inga Hansen‐Abeck, Mina Hillemans, Finn Abeck, Stefan W. Schneider, Nina Booken   +4 more
wiley   +1 more source

Deciphering the panvascular immune landscape of atherosclerosis

VIEW, Volume 6, Issue 4, August 2025.
Atherosclerosis (AS) involves inflammation in major arteries and can cause severe cardiovascular events like heart attacks and strokes, yet disease patterns vary significantly between arteries, complicating diagnosis and treatment. In this study, we integrated transcriptomic and single‐cell RNA sequencing data from AS plaques across five key arterial ...
Yiming Zhong, Yifan Chen, Yuehong Wang, Wenhai Pan, Honghao Huang, Lin Lin Cao, Yili Wang, Jiawen Zhang, Yunyi Liang, Xiangyue Qian, Chenxi Shi, Xiyuan Lu, Jun Pu   +12 more
wiley   +1 more source

Clofibrate Relaxes the Longitudinal Smooth Muscle of the Mouse Distal Colon through Calcium-Mediated Desensitisation of Contractile Machinery

, 2011
Peroxisome proliferator-activated receptor α (PPAR-α) is a ligand-activated transcription factor that exerts strong effects on metabolic pathways. Our aim was to elucidate the effect of clofibrate, a PPAR-α agonist, on the longitudinal muscle of the ...
Hidemitsu Nakajima, Ai Morioka, Yasu-Taka Azuma, Kazuhiro Nishiyama, Tadayoshi Takeuchi   +4 more
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Nuclear Receptor ERRγ Protects Against Cardiac Ischemic Injury by Suppressing GBP5‐Mediated Myocardial Inflammation

The FASEB Journal, Volume 39, Issue 14, 31 July 2025.
Cardiomyocyte‐specific overexpression of ERRγ after myocardial infarction improves cardiac function by suppressing the expression of its pro‐inflammatory downstream target GBP5, thereby inhibiting inflammasome assembly, alleviating myocardial inflammation, and pyroptosis.
Junhao Qiu, Qianji Che, Yichao Zhang, Mu Chen, Zhixing Wei, Yangjinming Bai, Tingting Zhao, Ji Yan, Zhengyang Wu, Zhentao Fei, Yuepeng Wang, Qian Wang, Yi‐Gang Li   +12 more
wiley   +1 more source

The Effect of Clofibrate on Neonatal Hyperbilirubinemia in Uncomplicated Jaundice

, 2008
Objective: Clofibrate has been used for several years as a hypolipidemic drug. Our aim was to study the effect of Clofibrate on neonatal hyperbilirubinemia in uncomplicated jaundice. Material & Methods: This clinical trial study has been conducted on 90
Badeli, Hamid R., Sharafi, Reza, Sajedi, Seyed Aidin   +2 more
core   +1 more source

Regulation of Carnitine Acyltransferase Synthesis in Lean and Obese Zucker Rats by Dehydroepiandrosterone and Clofibrate

, 1991
The effects of dehydroepiandrosterone (DHEA) and clofibrate on mitochondrial and peroxisomal proliferation and carnitine acyltransferases [mitochondrial carnitine palmitoyltransferase (CPT) and peroxisomal carnitine octanoyltransferase (COT)] were ...
Rona R. Ramsay, Linda J. Brady, Ramsay, R. R., Brady, P. S., Paul S. Brady, Brady, L. J.   +5 more
core   +1 more source

Optimized Dynamic Network Biomarker Deciphers a High‐Resolution Heterogeneity Within Thyroid Cancer Molecular Subtypes

Med Research, Volume 1, Issue 1, Page 10-31, June 2025.
An optimized dynamic network biomarker approach reveals a critical transition signal and identifies three distinct molecular subtypes of differentiated thyroid cancer, each with unique global regulatory landscapes. ABSTRACT The progression of differentiated thyroid carcinoma (DTC) poses significant clinical challenges, especially in determining the ...
Haonan Zhang, Ge Zhang, Pengyuan Xu, Fengyi Yu, Liwen Li, Runzhi Huang, Pengpeng Zhang, Kaisaierjiang Kadier, Yuanyuan Wang, Qiqi Gu, Yalei Ding, Tianshu Gu, Hao Chi, Shiqian Zhang, Ruhao Wu, Yudi Xu, Shanshan Zhu, Honglin Zheng, Taiqi Zhao, Qi He, Xinguang Qiu   +20 more
wiley   +1 more source

Reaction of caesium 4-chlorophenate and chlorohydrins from threonines: synthesis of clofibrate analogues

, 2005
Clofibrate is a well-known peroxisome proliferator-activated receptor-a (PPARa) agonist, used in the treatment of hyperlipaemias and atherosclerosis and to prevent heart failure.
Maria Grazia Perrone, BERTOLASI V., Ernesto Santandrea, Francesco Capitelli, PERRONE, MARIA GRAZIA, SANTANDREA E, CAPITELLI F, DI NUNNO L, Antonio Scilimati, Vincenzo Tortorella, TORTORELLA V, Leonardo Di Nunno, SCILIMATI, Antonio, Valerio Bertolasi   +13 more
core   +1 more source