Results 11 to 20 of about 4,936 (166)

Treatment of Xanthoma disseminatum - a systematic literature review. [PDF]

J Dtsch Dermatol Ges
Summary Xanthoma disseminatum is a rare disease from the spectrum of non‐Langerhans cell histiocytoses, which can be categorized into three types and is sometimes associated with systemic involvement. Due to the its rarity, there are no standardized treatment guidelines for this disease, making treatment in everyday clinical practice more difficult ...
Hansen-Abeck I, Hillemans M, Abeck F, Schneider SW, Booken N.   +4 more
europepmc   +2 more sources

Dispersion-Enhanced Nitrogen-Centered Photocatalysis of the Direct Hydrogen Atom Transfer. [PDF]

Angew Chem Int Ed Engl
Nitrogen‐centered acridine photocatalysts for direct hydrogen atom transfer have been developed, leveraging dispersion interactions to enhance photocatalytic activity. This approach enables diverse functionalization reactions of strong C─H bonds even under cryogenic conditions and provides a new strategy for boosting the efficiency of direct HAT ...
Zhang J, Zhuang K, Trevino R, Dhungana BR, Sun H, Yin S, Li Y, Sanchez JA, Xia X, Elerian R, Sun Y, Fremin SO, Huang C, He M, Cheng M, Larionov OV, Jin S.   +16 more
europepmc   +3 more sources

Clofibrate Induces Heme Oxygenase 1 Expression through a PPARα-Independent Mechanism in Human Cancer Cells

, 2013
Background and Aims: Clofibrate, an established PPARα ligand, has recently been shown to have anticancer activity yet its mechanisms of action remain to be characterized.
Shuai Wang, Jundong Zhou, Wei-Qun Ding, Bethany N. Hannafon   +3 more
core   +1 more source

Review Article: Targeting Peroxisome Proliferator‐Activated Receptors in Primary Biliary Cholangitis

Alimentary Pharmacology &Therapeutics, Volume 63, Issue 9, Page 1215-1235, May 2026.
Peroxisome proliferator‐activated receptor (PPAR) agonists have emerged as important second‐line treatments in primary biliary cholangitis, with profiles influenced by different selectivity for α‐, δ‐ and γ‐isoforms. PPAR‐α and PPAR‐δ agonism improve cholestasis, with inflammation reduced via all isoforms. PPAR‐δ agonism also reduces pruritus.
Jörn M. Schattenberg, Jesus M. Banales, Gideon Hirschfield, Palak Trivedi, Edward E. Cable, Charles A. McWherter, Andrew N. Billin, Daria B. Crittenden, Grant Budas   +8 more
wiley   +1 more source

Potential Effects of Aspirin on Transcription Factors Related to the Inflammation in Atherosclerosis: A Systematic Review

Health Science Reports, Volume 9, Issue 4, April 2026.
ABSTRACT Background and Aims Atherosclerosis (AS), a major cause of cardiovascular mortality, involves chronic inflammation mediated by transcription factors such as NF‐κB, PPARs, and AP‐2α. Beyond its antiplatelet role, aspirin exerts anti‐inflammatory effects that may influence these molecular pathways.
Mojtaba Aghaei, Reyhane Khademi, Seyed Sobhan Bahreiny, Habib Haybar, Ekhlas Torfi, Shirin Azizidoost, Najmaldin Saki   +6 more
wiley   +1 more source

CYP4X1/sEH‐Dependent Endocannabinoid Metabolism Drives Fibroblast‐Mediated Immunosuppression to Limit Immunotherapy in Colon Cancer

Advanced Science, Volume 13, Issue 5, 27 January 2026.
A proposed mechanism to explain the role of CYP4X1/sEH‐14,15‐EET‐EA system in colon cancer immune escape. 14,15‐EET‐EA, 14,15‐epoxyeicosatrienoic acid‐ethanolamide; sEH, soluble epoxide hydrolase; CYP4X1, cytochrome P450 4X1; GPR119, G‐protein coupled receptor 119; EGFR, epidermal growth factor receptor; Gs, Gαs subunit; cAMP, cyclic adenosine ...
Min Mo, Xuewei Chen, Yanzhuo Liu, Chenlong Wang, Xuehan Chen, Nan Zhang, Nan He, Ying Li, Jingyi Wang, Honglei Chen, Jing Yang   +10 more
wiley   +1 more source

The Mechanistic Role of PPARγ in Wound Healing

PPAR Research, Volume 2026, Issue 1, 2026.
The receptor known as peroxisome proliferator‐activated receptor gamma (PPARγ) is crucial for effective wound healing, and recent progress has given a deeper understanding of its complex functions. As a biological switch, PPARγ regulates the immune response by shifting macrophages from promoting inflammation to supporting tissue regeneration, while ...
Zhaojun Wang, Kaixing Jia, Wei Wang, Xiaolong Du, Yueyan Wu, Jianan Wang, John P. Vanden Heuvel   +6 more
wiley   +1 more source

A Cell‐Penetrating Scorpion Venom Peptide Disrupts the HSP90β‐PPARα Interaction to Ameliorate Metabolic Dysfunction‐Associated Steatotic Liver Disease

iMetaMed, Volume 1, Issue 2, December 2025.
In MASLD, increased HSP90β interacts with PPARα, thereby inhibiting PPARα activation via the inhibition of its nuclear translocation. BmK Tx‐2, a cell‐penetrating peptide from Buthus martensii Karsch scorpion venom, enters hepatocytes via macropinocytosis and escapes endosomes to bind HSP90β.
Erjin Xu, Wuguang Lu, Yonggen Chen, Ming Sang, Jiao Chen, Xueting Cai, Wenhao Xu, Yuxin Zhang, Zhiheng Wang, Feng Zhang, Peng Cao   +10 more
wiley   +1 more source

Silent Dangers in Elderly Pharmacotherapy: The Interplay of Polypharmacy, Multimorbidity, and Drug Interactions

Journal of Evaluation in Clinical Practice, Volume 31, Issue 7, October 2025.
ABSTRACT Background Pharmacological therapy in older persons is inherently complex due to the interplay of age‐related physiological changes, multimorbidity, and polypharmacy. These factors increase the vulnerability of elderly patients to drug interactions and adverse drug reactions.
N. N. Ngcobo
wiley   +1 more source

COMPARING THE EFFECT OF CLOFIBRATE AND PHENOBARBITAL ON THE NEWBORNS WITH HYPERBILIRUBINEMIA [PDF]

, 2013
The aim of treating hyperbilirubinemia is preventing the serum bilirubin to reach neurotoxic levels, which is done by phototherapy or blood transfusion. However, pharmacological treatments still remain vague.
Zamanzad, Behnam., Mesripour, Azadeh., Hamidi, Majid.   +2 more
core   +3 more sources