Results 31 to 40 of about 8,788 (204)

Cytoprotective effects of melatonin against amitriptyline-induced toxicity in isolated rat hepatocytes [PDF]

, 2015
Purpose: Amitriptyline, one of the commonly used tricyclic antidepressants, caused rare but severe hepatotoxicity in patients who received it continuously. Previous findings showed that the intermediate metabolites of amitriptyline produced by CYP450 are
Dastmalchi, S., Eghbal, M.A., Sattari, M.R., Taziki, S.   +3 more
core   +1 more source

In vitro cholesterol synthesis in freshly isolated mononuclear cells of human blood: effect of in vivo administration of clofibrate and/or cholestyramine.

Journal of Lipid Research, 1980
The rate of incorporation of [2-14C]acetate into cholesterol has been measured in freshly isolated peripheral blood mononuclear leukocytes from patients on various hypolipidemic drugs that affect whole body cholesterol synthesis.
D J McNamara, N O Davidson, S Fernandez
doaj   +1 more source

Potential Effects of Aspirin on Transcription Factors Related to the Inflammation in Atherosclerosis: A Systematic Review

Health Science Reports, Volume 9, Issue 4, April 2026.
ABSTRACT Background and Aims Atherosclerosis (AS), a major cause of cardiovascular mortality, involves chronic inflammation mediated by transcription factors such as NF‐κB, PPARs, and AP‐2α. Beyond its antiplatelet role, aspirin exerts anti‐inflammatory effects that may influence these molecular pathways.
Mojtaba Aghaei, Reyhane Khademi, Seyed Sobhan Bahreiny, Habib Haybar, Ekhlas Torfi, Shirin Azizidoost, Najmaldin Saki   +6 more
wiley   +1 more source

Modulation of cytosolic phospholipase A2 by PPAR activators in human preadipocytes

Journal of Lipid Research, 2001
Cytosolic phospholipase A2 (cPLA2) is responsible for the release of arachidonic acid, a precursor for eicosanoid biosynthesis, from cellular phospholipids.
Yan J. Jiang, Grant M. Hatch, David Mymin, Thomas Dembinski, Edwin A. Kroeger, Patrick C. Choy   +5 more
doaj   +1 more source

Effect on cardiovascular risk of high density lipoprotein targeted drug treatments niacin, fibrates, and CETP inhibitors: meta-analysis of randomised controlled trials including 117 411 patients [PDF]

, 2014
Objective To investigate the effects on cardiovascular outcomes of drug interventions that increase high density lipoprotein levels. Design Meta-analysis.
Francis, DP, Keene, D, Price, C, Shun-Shin, MJ   +3 more
core   +1 more source

Elucidating the mechanistic relationships between peroxisome proliferator–activated receptors and hepatic fibrosis using the ROBOKOP knowledge graph

Frontiers in Toxicology
We developed the Reasoning Over Biomedical Objects linked in Knowledge Oriented Pathways (ROBOKOP) application as an open-source knowledge graph system to support evidence-based biomedical discovery and hypothesis generation.
Karamarie Fecho, Karamarie Fecho, Nyssa Tucker, Jon-Michael Beasley, Scott S. Auerbach, Chris Bizon, Alexander Tropsha, Alexander Tropsha, Alexander Tropsha   +8 more
doaj   +1 more source

Determination of clofibrate in biological fluids by thin-layer and gas—liquid chromatography

Journal of Lipid Research, 1974
A specific and sensitive method is described for the detection of clofibrate in biological fluids. The drug is separated from associated fatty acids by thin-layer chromatography and the methyl ester is quantified by gas—liquid chromatography. Recovery is
A. Sedaghat, H. Nakamura, E.H. Ahrens, Jr.   +2 more
doaj   +1 more source

Effects of treatment with clofibrate, bezafibrate, and ciprofibrate on the metabolism of cholesterol in rat liver microsomes.

Journal of Lipid Research, 1989
The effects of treatment of rats with clofibrate, bezafibrate, and ciprofibrate on the hepatic metabolism of cholesterol were studied in rat liver microsomes.
D Ståhlberg, B Angelin, K Einarsson
doaj   +1 more source

CYP4X1/sEH‐Dependent Endocannabinoid Metabolism Drives Fibroblast‐Mediated Immunosuppression to Limit Immunotherapy in Colon Cancer

Advanced Science, Volume 13, Issue 5, 27 January 2026.
A proposed mechanism to explain the role of CYP4X1/sEH‐14,15‐EET‐EA system in colon cancer immune escape. 14,15‐EET‐EA, 14,15‐epoxyeicosatrienoic acid‐ethanolamide; sEH, soluble epoxide hydrolase; CYP4X1, cytochrome P450 4X1; GPR119, G‐protein coupled receptor 119; EGFR, epidermal growth factor receptor; Gs, Gαs subunit; cAMP, cyclic adenosine ...
Min Mo, Xuewei Chen, Yanzhuo Liu, Chenlong Wang, Xuehan Chen, Nan Zhang, Nan He, Ying Li, Jingyi Wang, Honglei Chen, Jing Yang   +10 more
wiley   +1 more source

Dietary moderately oxidized oil induces expression of fibroblast growth factor 21 in the liver of pigs [PDF]

, 2012
BACKGROUND: Fibroblast growth factor 21 (FGF21), whose expression is induced by peroxisome proliferator-activated receptor alpha (PPARalpha), has been recently identified as a novel metabolic regulator which plays a crucial role in glucose homeostasis ...
Eder, Klaus, Ringseis, Robert, Varady, Juliane   +2 more
core   +2 more sources