Results 1 to 10 of about 4,936 (166)

Clofibrate

, 2007
Clofibrate is the prototypical member of the fibrate class of antihyperlipidemic drugs. Although not clearly understood, its mechanism of action involves activation of PPARalpha which increases transcription of lipoprotein lipase which, in turn, enhances
Robert J. Theobald, Theobald, Robert J.
openaire   +2 more sources

Effects of maternal feeding of clofibrate on hepatic fatty acid metabolism in suckling piglet. [PDF]

J Anim Sci Biotechnol
Background Energy deficiency is a leading cause of the high pre-weaning mortality of neonatal piglets in the swine industry. Thus, optimal energy metabolism is of crucial importance for improving the survivability of neonatal piglets.
Zhao J, Pike B, Wang F, Yang L, Meisner P, Huang Y, Odle J, Lin X.   +7 more
europepmc   +2 more sources

Effects of Maternal Clofibrate Supplementation During Gestation and Lactation on Intestinal Fatty Acid Oxidation of Suckling Piglets. [PDF]

Int J Mol Sci
To accelerate maturation of intestinal function and promote growth and development, the effect of maternal clofibrate on intestinal fatty acid (FA) metabolism was investigated in suckling piglets.
Pike B, Zhao J, Hicks JA, Wang F, Meisner P, Yang L, Liu HC, Odle J, Lin X.   +8 more
europepmc   +2 more sources

Intestinal Carnitine Status and Fatty Acid Oxidation in Response to Clofibrate and Medium-Chain Triglyceride Supplementation in Newborn Pigs. [PDF]

Int J Mol Sci, 2023
To investigate the role of peroxisome proliferator-activated receptor alpha (PPARα) in carnitine status and intestinal fatty acid oxidation in neonates, a total of 72 suckled newborn piglets were assigned into 8 dietary treatments following a 2 ...
Pike B, Zhao J, Hicks JA, Wang F, Hagen R, Liu HC, Odle J, Lin X.   +7 more
europepmc   +2 more sources

Effects of Clofibrate on Salt Loading-Induced Hypertension in Rats [PDF]

, 2011
The effects of clofibrate on the hemodynamic and renal manifestations of increased saline intake were analyzed. Four groups of male Wistar rats were treated for five weeks: control, clofibrate (240 mg/kg/day), salt (2% via drinking water), andsalt ...
Isabel Rodríguez-Gómez, Juan Manuel Moreno, Antonio Osuna, Antonio Cruz, Rosemary Wangensteen, Andrés Quesada, Rocío Pérez-Abud, Miguel Ángel Vargas   +7 more
core   +1 more source

The effects of clofibrate on neonatal jaundice: A systematic review [PDF]

, 2022
Background: Neonatal jaundice is a prevalent disease that causes many complications, including kernicterus and even death. Previous studies have shown that clofibrate as an aryloxy isobutyric acid derivate can be effectively applied for the treatment of ...
Eghbalian, Fatemeh, Hasanpour- Dehkordi, Ali, Raeisi, Roya   +2 more
core  

Clofibrate improves glucose tolerance in fat-fed rats but decreases hepatic glucose consumption capacity

, 2002
Background/Aims: High-fat (HF) diets cause glucose intolerance. Fibrates improve glucose tolerance. We have tried to obtain information on possible hepatic mechanisms contributing to this effect.
Wiegman, C, Romijn, Johannes A., Kuipers, F, Wiegman, Coen, Gustafson, LA, Romijn, JA, Gustafson, Lori A., Sauerwein, Hans P., Kuipers, F; id_orcid, Kuipers, Folkert, Meijer, Alfred J., Sauerwein, HP, Meijer, AJ   +12 more
core   +2 more sources

Benefit of Clofibrate on indirect hyperbilirubinemia in newborn

, 2018
Background: hyperbilirubinemia develop in all newborns and resolves within the first several weeks after birth. Clofibrate is planned for management of indirect hyperbilirubinemia Aim: to evaluate Benefit of Clofibrate on indirect hyperbilirubinemia in ...
Baha D. Moohy Alosy
core   +1 more source

Mechanism of increased hepatic concentration of carnitine by clofibrate

, 1986
Our previous studies have shown that treatment of rats with clofibrate, a hypolipidemic drug, greatly increases the total concentration of carnitine in the liver (H. S. Paul and S. A. Adibi, J. Clin. Invest. 64: 405-412, 1979).
S. A. Adibi, H. S. Paul, C. E. Gleditsch
core   +1 more source

The Treatment of Cerebrovascular Disease With Clofibrate

, 1973
A cooperative study in 20 Veterans Administration hospitals investigated the effect of clofibrate on morbidity and mortality due to atherosclerotic vascular disease in men with either an established cerebral infarction or transient cerebrovascular ...

core   +1 more source