Results 1 to 10 of about 8,788 (204)

Effects of maternal feeding of clofibrate on hepatic fatty acid metabolism in suckling piglet [PDF]

Journal of Animal Science and Biotechnology
Background Energy deficiency is a leading cause of the high pre-weaning mortality of neonatal piglets in the swine industry. Thus, optimal energy metabolism is of crucial importance for improving the survivability of neonatal piglets.
Jinan Zhao, Brandon Pike, Feng Wang, Lin Yang, Paige Meisner, Yanling Huang, Jack Odle, Xi Lin   +7 more
doaj   +2 more sources

Peroxisome Proliferator Activator α Agonist Clofibrate Induces Pexophagy in Coconut Oil-Based High-Fat Diet-Fed Rats [PDF]

Biology
Peroxisomes are crucial for fatty acid β-oxidation in steatosis, but the role of pexophagy—the selective autophagy of peroxisomes—remains unclear. This study investigated the effects of the peroxisome proliferator-activated receptor-α (PPARα) agonist ...
Kanami Ohshima, Emika Hara, Mio Takimoto, Yidan Bai, Mai Hirata, Wen Zeng, Suzuka Uomoto, Mai Todoroki, Mio Kobayashi, Takuma Kozono, Tetsuhito Kigata, Makoto Shibutani, Toshinori Yoshida   +12 more
doaj   +2 more sources

Evaluation of Carnitine Status in Postnatal Piglets from Sows Fed Clofibrate [PDF]

Current Issues in Molecular Biology
Milk carnitine content decreases quickly with lactation days and is accompanied by PPARα downregulation. This study aimed to investigate the effects of the maternal supplementation of the PPARα agonist, clofibrate, on milk carnitine content and carnitine
Brandon Pike, Jinan Zhao, Julie A. Hicks, Tim Boston, Hsiao-Ching Liu, Jack Odle, Xi Lin   +6 more
doaj   +2 more sources

CLOFIBRATE [PDF]

Lancet, The, 1979
exaly   +12 more sources

Clofibrate in the Treatment of the Non-hemolytic Hyperbilirubinemia in Preterm Neonates in Western Iran [PDF]

Iranian Journal of Neonatology, 2021
Background: No studies, to the best of our knowledge, have been conducted on the effect of Clofibrate in reducing hyperbilirubinemia in preterm infants.
fatemeh eghbalian, Ensiyeh Jenabi, Elham Hatami, Behnaz Basiri, Katayoun Derakhshandeh, Nasrollah Pezeshki, Elham Khanlarzadeh   +6 more
doaj   +1 more source

Evaluation of the Effect of Oral Clofibrate Intake on Neonatal Total Serum Bilirubin: a Randomized Clinical Trial [PDF]

Iranian Journal of Neonatology, 2016
Background: Clofibrate is a pharmacological agent, which affects the lipid metabolism. This compound could be involved in bilirubin accumulation and excretion process.
Mahmood NouriShadkam, Mohmmad Javad Mohammadi, Khadijeh Nasiriani   +2 more
doaj   +1 more source

The effects of clofibrate on neonatal jaundice: A systematic review

International Journal of Preventive Medicine, 2022
Background: Neonatal jaundice is a prevalent disease that causes many complications, including kernicterus and even death. Previous studies have shown that clofibrate as an aryloxy isobutyric acid derivate can be effectively applied for the treatment of ...
Fathemeh Eghbalian, Ali Hasanpour- Dehkordi, Roya Raeisi   +2 more
doaj   +1 more source

Effect of clofibrate on reducing neonatal jaundice: a systematic review and meta-analysis [PDF]

Osong Public Health and Research Perspectives, 2022
In neonates, bilirubin tends to be deposited in body tissues, especially the skin and mucous membranes. Jaundice is an early symptom of bilirubin excretion disorders.
Fatemeh Eghbalian, Lotfollah Karimi, Roya Raeisi, Ayda Hasanpour Dehkordi, Hamid Bouraghi   +4 more
doaj   +1 more source

Effects of medium chain triglycerides on hepatic fatty acid oxidation in clofibrate-fed newborn piglets

Animal Nutrition, 2023
To investigate whether increasing tricarboxylic acid (TCA) cycle activity and ketogenic capacity would augment fatty acid (FA) oxidation induced by the peroxisome proliferator-activated receptor-alpha (PPARα) agonist clofibrate, suckling newborn piglets (
Jinan Zhao, Brandon Pike, Jin Huang, Zhihua Feng, Jack Odle, Xi Lin   +5 more
doaj   +1 more source

Clofibrate improves myocardial ischemia-induced damage through regulation of renin-angiotensin system and favours a pro-vasodilator profile in left ventricle

Journal of Pharmacological Sciences, 2020
Myocardial ischemia initiates a chain of pathological conditions leading to cardiomyocyte death. Therefore, pharmacological treatment to stop ischemia-induced damage is necessary.
L. Ibarra-Lara, M. Sánchez-Aguilar, L. Del Valle-Mondragón, E. Soria-Castro, L.G. Cervantes-Pérez, G. Pastelín-Hernández, A. Sánchez-Mendoza   +6 more
doaj   +1 more source