Results 61 to 70 of about 8,788 (204)

Assessments of CYP‐Inhibition‐Based Drug–Drug Interactions Between Tofacitinib and Lipid‐Lowering Agents in Rats Both In Vitro and In Vivo

Pharmacology Research &Perspectives, Volume 13, Issue 3, June 2025.
ABSTRACT Tofacitinib is a widely used medication for the treatment of arthritis. It has been reported that some patients experience abnormal cholesterol levels following treatment, leading to recommendations for the coadministration of lipid‐lowering drugs such as statins.
Hang Yang, Shuanghu Wang, Quan Zhou, Peiwu Geng, Zebei Lu, Qinrong Lin, Chunhong Chen, Yunfang Zhou, Jianping Cai, Dapeng Dai   +9 more
wiley   +1 more source

Niacin-induced clotting factor synthesis deficiency with coagulopathy [PDF]

, 1992
Although coagulopathy is a well-known complication of severe niacin- induced hepatotoxic reaction, it is not found in patients with minimal aminotransferase level elevations.
Dearing, Brian D., Genton, Edward, Lavie, Carl J., Lohmann, Thomas P.   +3 more
core   +1 more source

Inhibition of lipid synthesis by clofibrate: comparative study of human skin, rat skin, and rat liver in vitro

Journal of Lipid Research, 1972
The effects of clofibrate (ethyl p-chlorophenoxyisobutyrate) on lipid synthesis by human skin were studied in vitro. The drug was found to inhibit lipid synthesis from [1-14C]acetate or [U-14C]glucose.
James E. Fulton, Jr., S.L. Hsia
doaj   +1 more source

Ibuprofen inhibits human sweet taste and glucose detection implicating an additional mechanism of metabolic disease risk reduction

British Journal of Pharmacology, Volume 182, Issue 12, Page 2682-2693, June 2025.
Background and Purpose The human sweet taste receptor, TAS1R2–TAS1R3, conveys sweet taste in the mouth and may help regulate glucose metabolism throughout the body. Ibuprofen and naproxen are structurally similar to known inhibitors of TAS1R2–TAS1R3 and have been associated with metabolic benefits.
Emily C. Hanselman, Caroline P. Harmon, Daiyong Deng, Sarah M. Sywanycz, Lauren Caronia, Peihua Jiang, Paul A. S. Breslin   +6 more
wiley   +1 more source

Nafenopin-induced rat liver peroxisome proliferation reduces DNA methylation by N-nitrosodimethylamine in vivo [PDF]

, 2017
The hypolipidaemic drug nafenopin (NAF) has been shown to enhance the hepatocarcinogenic effect of N-nitrosodimethylamine (NDMA) and N-nitrosodiethylamine in rats.
Fringes, Birgitta, Kleihues, Paul, Schmerold, Ivo, Volk, Benedikt, Wiestler, Otmar D.   +4 more
core  

BCAA catabolism in brown fat controls energy homeostasis through SLC25A44. [PDF]

, 2019
Branched-chain amino acid (BCAA; valine, leucine and isoleucine) supplementation is often beneficial to energy expenditure; however, increased circulating levels of BCAA are linked to obesity and diabetes.
A Balkow, A Bartelt, AM Cypess, Ayano Ueno, B Tasic, C Jang, Carlos Henrique Sponton, CB Newgard, CB Newgard, CJ Lynch, CR Green, CT Ferrara, DE Lackey, EG Sustarsic, F Palmieri, Francis C. Szoka, H Ohno, Haruya Takahashi, Hiroko Maki, Homa Majd, Huixia Li, K Ikeda, K Shinoda, Kaori Igarashi, Kazuki Tajima, KC Das, Kenji Ikeda, KH Pietiläinen, KM Huffman, Kyeongkyu Kim, LA Gilbert, Labros Sidossis, M Chondronikola, M Rosell, M Saito, M Wallace, MA Herman, Maki Ohishi, Mami Matsushita, Maria Chondronikola, Masayuki Saito, MD Neinast, Michael T. McManus, Mito Kuroda, Momoko Yoneshiro, Olga R. Ilkayeva, P She, Phillip J. White, PJ White, PJ White, Qiang Wang, Rachana N. Pradhan, Robert W. McGarrah, SH Um, Shingo Kajimura, T Li, T Soga, T Soga, T Yoneshiro, Takamasa Ishikawa, Takeshi Yoneshiro, Teruo Kawada, TJ Wang, Tomoyoshi Soga, Tsuyoshi Goto, V Ouellet, Vanille Juliette Greiner, X Kong, Yann Deleye, Yasuo Oguri, Yong Chen, Zachary Brown, Zhipeng Dai   +72 more
core   +1 more source

Clofibrate Attenuates ROS Production by Lipid Overload in Cultured Rat Hepatoma Cells

Journal of Pharmacy & Pharmaceutical Sciences, 2017
PURPOSE: To investigate the effect of clofibrate on inducing liver fatty acid binding protein (FABP1) following a high-fat load in a hepatocyte cell culture model.
Yufei Chen, Wei Li, Guqi Wang, Frank J Burczynski   +3 more
doaj   +1 more source

A Hypothesis: Metabolic Contributions to 16p11.2 Deletion Syndrome

BioEssays, Volume 47, Issue 3, March 2025.
16p11.2 Deletion syndrome is associated with brain, body, and behavioral symptoms. A majority of 16p11.2 genes relate to metabolism, involving amino acids/proteins, DNA, RNA, catabolism, lipids, and carbohydrates. Additional contributions include changes in cell structure, signaling, development, immune system, nervous system, and localization.
Brandon Kar Meng Choo, Sarah Barnes, Hazel Sive   +2 more
wiley   +1 more source

Different Responses of Cardiac Cells to Saturated and Unsaturated Fatty Acids

پزشکی بالینی ابن سینا, 2007
Introduction & Objective: The link between dietary fat and coronary heart disease has attracted much attention since the effect of long?chain fatty acids (LCFA) on gene transcription has been established, which in part, these effects can be explained by ...
Iraj Khodadadi, Alfred Thumser
doaj  

Decrypting the Possible Mechanistic Role of Fenofibrate in Alzheimer's Disease and Type 2 Diabetes: The Truth and Mystery

Journal of Cellular and Molecular Medicine, Volume 29, Issue 5, March 2025.
ABSTRACT Alzheimer's disease (AD) is a neurodegenerative disease caused by the progressive deposition of extracellular amyloid beta (Aβ) and intracellular neurofibrillary tangles (NFTs). Of note, metabolic disorders such as insulin resistance (IR) and type 2 diabetes (T2D) are associated with the development of brain IR and associated neurodegeneration.
Mansour A. Alsaleem, Hayder M. Al‐Kuraishy, Ali I. Al‐Gareeb, Maha M. Abdel‐Fattah, Mohammed Alrouji, Nasser A. Al‐Harchan, Mubarak Alruwaili, Marios Papadakis, Athanasios Alexiou, Gaber El‐Saber Batiha   +9 more
wiley   +1 more source