Results 161 to 170 of about 187,082 (288)

Revisiting Clonal Evolution Through the Light of Retrotransposons. [PDF]

Bioessays
Lamoureux A, Elvira-Matelot E, Porteu F, Laplane L.   +3 more
europepmc   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Molecular variants, clonal evolution and clinical relevance in pediatric and adult T-cell lymphoblastic neoplasia. [PDF]

Blood Cancer J
Sandmann S, Te Vrugt M, Randau G, Beder T, Neumann M, Lange T, Alfert A, Mueller S, Hotfilder M, Rossi C, Eckert C, Moericke A, Horns JM, Zimmermann M, Varghese J, Brüggemann M, Burkhardt B.   +16 more
europepmc   +1 more source

Non-clonal evolution of microbes [PDF]

Biological Journal of the Linnean Society, 2003
RAVI JAIN, MARIA C. RIVERA, JONATHAN E. MOORE, JAMES A. LAKE   +3 more
openaire   +1 more source

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

Resolving clonal evolution and selection of extrachromosomal DNA at single-cell resolution. [PDF]

Genome Biol
Hendriksen JD, Locallo A, Schlotmann BC, González FGR, Skjøth-Rasmussen J, Yde CW, Nørøxe DS, Poulsen HS, Lassen U, Weischenfeldt J.   +9 more
europepmc   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

MYC-positive follicular lymphoma complicated by refractory lactate and clonal evolution: a case report. [PDF]

Front Oncol
Wang YQ, Wang KX, Yu HJ, Yang KP, Li DY, Wang Y, Liu Y, Meng J, Wang SY.   +8 more
europepmc   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Clonal Evolution of Pancreatobiliary Neoplasms

Archives of Pathology & Laboratory Medicine
Huamin, Wang, Olca, Basturk
openaire   +2 more sources