Results 231 to 240 of about 107,781 (288)

Plasmid-associated clonal expansion drives department-preference transmission of carbapenem-resistant <i>Klebsiella pneumoniae</i> in Xi'an, China: a genomic epidemiology study. [PDF]

Front Cell Infect Microbiol
Luo K, Liu S, Feng J, Li R, Zhang S, Yu R, Li F, Li Y, Wu K, Wang J, Xie T, Lei J, Yin Z, Han L.   +13 more
europepmc   +1 more source

Metabolic Imbalance Triggers Adaptive Remodeling to Accelerate Diploidization in Murine Haploid Embryonic Stem Cells

Advanced Science, EarlyView.
In this article, Shuai and colleagues demonstrate that metabolic remodeling drives self‐diploidization in murine haploid ESCs (haESCs). Mitochondrial dysfunction and imbalanced pyruvate metabolism underlie this process. Genome‐wide screening using haESCs identifies key mitochondrial quality‐control related genes, enabling a metabolism‐based medium that
Yi Fu, Wenhao Zhang, Yifan Zhang, Yu He, Yi Du, Yiding Zhao, Chunmeng Yao, Shengyi Sun, Xiaoyan Sheng, Qian Gao, Chao Tong, Ling Shuai   +11 more
wiley   +1 more source

Multistage carcinogenesis in occupational cholangiocarcinoma: the impact of clonal expansion and risk estimation. [PDF]

Genes Environ
Watanabe M, Haeno H, Mimaki S, Tsuchihara K.   +3 more
europepmc   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Vaccines combining slow release and follicle targeting of antigens increase germinal center B cell diversity and clonal expansion. [PDF]

Sci Transl Med
Rodrigues KA, Zhang YJ, Lam J, Aung A, Morgan DM, Romanov A, Maiorino L, Yousefpour P, Gibson G, Ozorowski G, Gregory JR, Amlashi P, Van R, Buckley M, Ward AB, Schief WR, Love JC, Irvine DJ.   +17 more
europepmc   +1 more source

MG53 Coordinates Macrophage Polarization and Neuroimmune Coupling to Promote Corneal Nerve Regeneration via the MPEG1–MVP–STAT6 Axis

Advanced Science, EarlyView.
Corneal nerve regeneration is critical to corneal wound healing processes. The current study reveals a novel role of MG53 in promoting corneal nerve regeneration after alkali induced injury. Mechanistically, MG53 enters macrophages via its receptor, MPEG1, promotes MVP K63 ubiquitination, and triggers STAT6 induced repair‐related genes expression ...
Peng Chen, Zhentao Zhang, Lilian Sakai, Yanping Xu, Luxi Zhang, Han Ye, William Sollenberger, Takahide Ikeda, Zhiyu Yan, Keerthika Sathish, Usman Alizai, Haitao Wen, Timothy M. Pawlik, Heather L. Chandler, Hua Zhu   +14 more
wiley   +1 more source

Widely dispersed clonal expansion of multi-fungicide-resistant <i>Aspergillus fumigatus</i> limits genomic epidemiology prospects. [PDF]

mBio
Snelders E, Celia-Sanchez BN, Nederlof YC, Zhang J, Kortenbosch HH, Zwaan BJ, Tehupeiory-Kooreman M, Giraldo-López A, van Dijk K, Wang L, Brewer MT, Momany M, Auxier B, Verweij PE.   +13 more
europepmc   +1 more source

APackOfTheClones: Visualization of clonal expansion with circle packing

Journal of Open Source Software
openaire   +1 more source

Disruption of the SNRPF–DDX24–E2F4 Feedback Loop Uncouples Splicing and Transcriptional Regulation to Suppress Ovarian Cancer Progression

Advanced Science, EarlyView.
This study identifies SNRPF as a critical oncogenic driver in ovarian cancer. By regulating a self‐sustaining SNRPF–DDX24–E2F4 feedback loop through intron retention and nonsense‐mediated decay, SNRPF couples RNA splicing with transcriptional regulation to promote tumor progression.
Yingwei Li, Zhongshao Chen, Qianqian Gao, Yuehan Gao, Ning Yang   +4 more
wiley   +1 more source

Comparing acute versus AIDS ART initiation on HIV-1 integration sites and clonal expansion. [PDF]

Signal Transduct Target Ther
Wang J, Xiao N, Zhu Z, Qiao H, Zhao F, Zhang L, Gou J, Lu M, He Y, Lu H, Li Q.   +10 more
europepmc   +1 more source