Results 241 to 250 of about 107,781 (288)

Dual Cytoplasmic and Chloroplastic Mechanisms Fine‐Tune Chloroplast Division through ARC3 Protein Stability

Advanced Science, EarlyView.
ARC3 levels are controlled by cytosolic and chloroplast proteolytic systems. PUB52 mediates ARC3 precursor ubiquitination and degradation in the cytosol, while CLPC1 promotes ARC3 degradation in chloroplasts, where ARC2 protects ARC3 from excessive breakdown. Disrupting these components causes chloroplast division defects, placing them upstream of ARC3.
Yang Yuan, Denghao Xiang, Ruiying Li, Zhichuang Yue, Zhipeng Wang, Honghong Hu   +5 more
wiley   +1 more source

Divergent Roles of mGlu2 and mGlu3 Receptors in Amyloid‐β Production and Cognitive Dysfunctions in Alzheimer's Disease

Advanced Science, EarlyView.
This study explores the opposing effects of the mGluR2 and mGluR3 receptors on amyloid precursor protein processing. mGluR2 promotes amyloidogenic cleavage, while mGluR3 favors non‐amyloidogenic pathways. Using a brain‐penetrant nanobody as a mGluR2 positive allosteric modulator, the study uncovers how its chronic activation aggravates amyloid‐β burden
Pierre‐André Lafon, Mireille Elodie Tsitokana, Ugo Guy Alenda, Yen‐Ling Lian, Clémentine Eva Philibert, Mathieu Oosterlaken, Marta Cimadevila, Gaëlle Dudon, Jessica Monnic, Salomé Roux, Julie Bessié, Séverine Diem, Franck Vandermoere, Laurent Prézeau, Patrick Chames, Julie Kniazeff, Sylvie Claeysen, Anaïs Menny, Jean‐Philippe Pin, Véronique Perrier, Jianfeng Liu, Philippe Rondard   +21 more
wiley   +1 more source

Low-dose interleukin-2 induces clonal expansion of BACH2-repressed effector regulatory T cells following acute coronary syndrome. [PDF]

Nat Cardiovasc Res
Case AG, O'Brien JW, Lu Y, Charlier FTW, Zhao X, Weng Y, Masters L, Tuong ZK, Sriranjan R, Cheriyan J, Kemper C, Clatworthy MR, Mallat Z, Zhao TX.   +13 more
europepmc   +1 more source

Arthrocolin B Impairs Adipogenesis via Delaying Cell Cycle Progression During the Mitotic Clonal Expansion Period. [PDF]

Int J Mol Sci
Cao G, Liao X, Zhao S, Li M, Xie Z, Yang J, Li Y, Zhu Z, Jin X, Huang R, Guo Z, Niu X, Ji X.   +12 more
europepmc   +1 more source

Ag-driven CD8 + T cell clonal expansion is a prominent feature of MASH in humans and mice. [PDF]

Hepatology
Burtis AEC, DeNicola DMC, Ferguson ME, Santos RG, Pinilla C, Kriss MS, Orlicky DJ, Tamburini BAJ, Tamburini BAJ, Gillen AE, Burchill MA.   +10 more
europepmc   +1 more source

Mealworm-Derived Protein Hydrolysates Enhance Adipogenic Differentiation via Mitotic Clonal Expansion in 3T3-L1 Cells. [PDF]

Foods
Ryu HJ, Lee SO.
europepmc   +1 more source

The longitudinal kinetics of AAV5 vector integration profiles and evaluation of clonal expansion in mice. [PDF]

Mol Ther Methods Clin Dev
Ismail AM, Witt E, Bouwman T, Clark W, Yates B, Franco M, Fong S.   +6 more
europepmc   +1 more source

Methicillin-resistant <i>Staphylococcus aureus</i> in Saudi Arabia: genomic evidence of recent clonal expansion and plasmid-driven resistance dissemination.

Front Microbiol
Alhejaili AY, Zhou G, Halawa H, Huang J, Fallatah O, Hirayban R, Iftikhar S, AlAsmari A, Milner M, Banzhaf M, Alzaidi AA, Rajeh AA, Al-Otaiby MA, Alabbad SS, Bukhari D, Aljurayyan AN, Aljasham AT, Alzeyadi ZA, Alajel SM, Alanazi RH, Alghoribi M, Almutairi MM, Pain A, Senok A, Moradigaravand D, Al Salem W.   +25 more
europepmc   +1 more source

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Clonal expansion of innate and adaptive lymphocytes

Nature Reviews Immunology, 2020
One of the hallmarks of the vertebrate adaptive immune system is the prolific expansion of individual cell clones that encounter their cognate antigen. More recently, however, there is growing evidence for the clonal expansion of innate lymphocytes, particularly in the context of pathogen challenge.
Nicholas M Adams, Simon Grassmann, Joseph C Sun   +2 more
exaly   +3 more sources

Aberrant activation of TCL1A promotes stem cell expansion in clonal haematopoiesis [PDF]

Nature, 2023
Mutations in a diverse set of driver genes increase the fitness of haematopoietic stem cells (HSCs), leading to clonal haematopoiesis(1). These lesions are precursors for blood cancers(2-6), but the basis of their fitness advantage remains largely ...
Jayakrishnan Gopakumar, Bala Bharathi Burugula, Md Mesbah Uddin   +2 more
exaly   +12 more sources