Results 261 to 270 of about 107,781 (288)
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Persistent clonal areas and clonal expansion in Barrett's esophagus.
Cancer research, 1992Three patients with Barrett's esophagus who had cytogenetic abnormalities detected in their metaplastic epithelium developed high-grade dysplasia or adenocarcinoma during prospective surveillance over a period of 1.5 to 6 years. In the 3 cases, cytogenetic abnormalities that were associated with the most advanced histological lesions were present in ...
W H, Raskind +5 more
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Studies on T Cell Clonal Expansion
The Journal of Immunology, 1975Abstract Spleen cells from C57BL/6 mice immunized with a DBA/2 mastocytoma (P815) were harvested at various stages of the immune response and cultured in vitro in the presence and absence of antigen. Killer T cell activity in immune spleens could not be demonstrated until 6 or 7 days after antigen, but spleen cells ...
Ramesh Kamat, Christopher S Henney
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Deciphering heterogeneity of preleukemic clonal expansion
2022Clonal expansion is a critical step in the early stage of leukemia genesis. While genetic mutations that induce expansion and increase disease risk --such as TET2, DNMT3a, and ASXL-- have been identified, these mutations are also frequently found in healthy individuals and many never progress to malignancy.
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Monitoring clonal expansion in the laboratory.
Clinical and experimental rheumatology, 1996The definitive demonstration of the clonal origin of an expanded B or T cell population is achieved by the molecular analysis of B or T cell receptor gene rearrangement. However, in recent years techniques that are both sensitive and relatively easy to carry out have been introduced as the first step to the diagnosis of clonality.
P, Sala, E, Tonutti
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Quantification of Clonal Expansion of Hepatocytes in Normal and Injured Liver
2022A fundamental part of understanding how a tissue regenerates is how individual cells that make up the tissue divide. This protocol describes a method to label a random and representative sampling of hepatocytes throughout the mouse liver and quantify their cell division and clonal expansion during homeostasis and after liver injury. Clonal expansion is
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The Influence of Somatic Mutation on Clonal Expansion
1989The key feature of the process of somatic diversification is that mutations accumulate sequentially during clonal expansion. This was first recognized from the hierarchy of shared mutations in antibodies from clonally related lymphocytes (McKean et al.
M. J. Shlomchik, S. Litwin, M. Weigert
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Clonal expansion mechanisms in paroxysmal nocturnal hemoglobinuria
International Journal of HematologyParoxysmal nocturnal hemoglobinuria (PNH) is characterized by complement-dependent intravascular hemolysis and thrombosis as well as bone marrow failure. Complement dysregulation occurs as a result of defective cell surface expression of two glycosylphosphatidylinositol (GPI)-anchored complement regulators, decay-accelerating factor/CD55 and CD59 ...
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Cellular and molecular bases of B-cell clonal expansions.
Clinical and experimental rheumatology, 1996The concept that lymphomagenesis is a multistep process is now widely accepted. Various factors are involved in the development and malignant progression of B-cell lymphoproliferative disorders. The most frequently recognized alterations in these disorders are chromosomal translocations which lead to the activation of proto-oncogenes (c-myc) or genes ...
Dolcetti, R, Boiocchi, M
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