Results 251 to 260 of about 107,781 (288)
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“Let”-ing go with clonal expansion?
Blood, 2011In this issue of Blood, Ikeda et al report the effects of the high mobility group A2 (Δhmga2) lacking the 3' untranslated region (UTR) in hematopoietic tissues. Overexpression of Δhmga2 in transgenic mice resulted in "big mice with big blood": the mice weighed more and had a myeloproliferative phenotype with increases in peripheral blood counts ...
Robert A Brodsky, Brodsky Robert A
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Clonal expansion and epigenetic inheritance of long-lasting NK cell memory [PDF]
Nature Immunology, 2022 Clonal expansion of cells with somatically diversified receptors and their long-term maintenance as memory cells is a hallmark of adaptive immunity. Here, we studied pathogen-specific adaptation within the innate immune system, tracking natural killer ...
Timo Rückert +2 more
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Clonal expansion in non-cancer tissues
Nature Reviews Cancer, 2021Cancer is a clonal disorder derived from a single ancestor cell and its progenies that are positively selected by acquisition of 'driver mutations'. However, the evolution of positively selected clones does not necessarily imply the presence of cancer.
Nobuyuki Kakiuchi, Seishi Ogawa
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On the parameters of the clonal expansion model
Radiation and Environmental Biophysics, 1996The exact hazard function of the clonal expansion model was analyzed, and it was shown that only three of its four parameters can be determined by fitting to the age dependence of spontaneous tumor incidence rates. The same holds for the survival function.
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Clonal Integration and the Expansion of Phragmites australis
Ecological Applications, 2000The recent expansion of the reed Phragmites australis in western Atlantic salt marshes has become a conservation concern. Historically, Phragmites was restricted to the terrestrial border of marshes, but now it aggressively invades lower elevations.
Lindsay Amsberry +3 more
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Acinar cell clonal expansion in pancreas homeostasis and carcinogenesis
Nature, 2021Pancreatic ductal adenocarcinoma (PDAC) is one of the leading causes of cancer deaths worldwide1. Studies in human tissues and in mouse models have suggested that for many cancers, stem cells sustain early mutations driving tumour development2,3. For the pancreas, however, mechanisms underlying cellular renewal and initiation of PDAC remain unresolved.
Patrick Neuhöfer +6 more
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Evolution of B-cell clonal expansions with age
Cellular Immunology, 2004B-cell clonal expansions (BCE) in young mice are transient, detectable for less than 4 weeks. In contrast, BCE in old mice persist more than 2 months. The greater persistence of BCE in old mice does not appear to be due to the age of the host as the survival of phenyloxazolone chicken serum albumin-induced BCE in most old mice was shorter than in young
Paul, Szabo +5 more
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Clonal Expansion of Lipopolysaccharide-Stimulated B Lymphocytes
The Journal of Immunology, 1974Abstract The effect of lipopolysaccharide from Gram-negative bacteria (LPS) on the activation and clonal expansion of B cell precursors specific for SRC has been studies in a microculture system. Results indicate that LPS can activate the precursor cells to antibody production in the absence of antigen and without ...
Quintans, J, Lefkovits, I
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Clonal expansions of B lymphocytes in old mice
The Journal of Immunology, 1997Abstract The effect of age on the diversity of the murine Ig heavy chain repertoire has been studied in unimmunized C57BL/6 mice. We examined the heterogeneity of complementarity-determining region 3 (CDR3) sizes of Ig mRNA of the IgM and IgG isotypes using two VH families, VHJ558 and VHQ52, which together account for approximately 65%
J, LeMaoult +5 more
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Modeling Clonal Expansion from M-FISH Experiments
Journal of Computational Biology, 2008A population genetic model is used to describe dynamical aspects of chromosomal abberations observed in M-FISH experiments. Linear differential equations model the evolution of relative frequencies of mutations. The unknown parameters involved are estimated by maximum likelihood methods.
Thomas Stolte +3 more
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