Results 241 to 250 of about 2,119,256 (322)

Widely dispersed clonal expansion of multi-fungicide-resistant <i>Aspergillus fumigatus</i> limits genomic epidemiology prospects. [PDF]

mBio
Snelders E, Celia-Sanchez BN, Nederlof YC, Zhang J, Kortenbosch HH, Zwaan BJ, Tehupeiory-Kooreman M, Giraldo-López A, van Dijk K, Wang L, Brewer MT, Momany M, Auxier B, Verweij PE.   +13 more
europepmc   +1 more source

Integrated Transcriptomics Reveals Evolutionary Trajectories and Cell Density‐Dependent Mechanisms in Aldosterone‐Producing Adenomas

Advanced Science, EarlyView.
Aldosterone‐producing adenomas (APAs) develop via two distinct paths: directly from adrenal zona glomerulosa (zG) cells, or stepwise from zG cells through aldosterone‐producing micronodules (APMs) before progressing to APAs. Advanced single‐cell and spatial analyses identified distinct cell states linked to oxidative stress and cell–cell interactions ...
Zhuolun Sun, Changying Jing, Martina Tetti, Siyuan Gong, Jia Wei, Yingxian Pang, Martin Reincke, Tracy Ann Williams   +7 more
wiley   +1 more source

Multistage carcinogenesis in occupational cholangiocarcinoma: the impact of clonal expansion and risk estimation. [PDF]

Genes Environ
Watanabe M, Haeno H, Mimaki S, Tsuchihara K.   +3 more
europepmc   +1 more source

Structural and Functional Characterization of EXPO‐Derived Extracellular Vesicles in Plants

Advanced Science, EarlyView.
In this study, 3D electron tomography (ET), cryo‐ET, and immunogold transmission electron microscopy (TEM) are employed to characterize plant extracellular vesicles (EVs) under physiological conditions. EVs are classified into three distinct categories according to their size, content, and molecular‐marker profiles. Furthermore, Exo70E2‐positive medium
Jiayang Gao, Yanbin Li, Shengqi Zhang, Yilin He, Zhiqi Liu, Juan Wang, Jingmin Hua, Jinyu Chen, Junru Zhong, Huan Zhong, Yiji Xia, Yong Cui, Liwen Jiang   +12 more
wiley   +1 more source

Store‐Operated Ca2+ Entry Controls Clonal Expansion of T Cells through Metabolic Reprogramming

Immunity, 2017
M. Vaeth, Mate Maus, S. Klein-Hessling, Elizaveta Freinkman, Jun Yang, M. Eckstein, S. Cameron, S. Turvey, E. Serfling, F. Berberich-Siebelt, Richard L. Possemato, S. Feske   +11 more
semanticscholar   +1 more source

FAPα+ Macrophages Orchestrate Immune Evasion in Multiple Myeloma by Dual Regulation of PD‐L1 and T Cell Senescence

Advanced Science, EarlyView.
ABSTRACT Multiple myeloma (MM) is a hematologic malignancy driven by clonal expansion of malignant plasma cells. Despite the long‐term disease control achieved with immunotherapies in some patients, treatment resistance remains a major cause of disease relapse.
Huiyao Gu, Zhenfeng Dai, Xi Huang, Enfan Zhang, Xinyuan Dai, Haoguang Chen, Wen Cao, Jinna Zhang, Yifan Hou, Haimeng Yan, Yang Yang, Li Yang, Yi Li, Wenlong Lin, Zhen Cai, Jingsong He   +15 more
wiley   +1 more source

Comparing acute versus AIDS ART initiation on HIV-1 integration sites and clonal expansion. [PDF]

Signal Transduct Target Ther
Wang J, Xiao N, Zhu Z, Qiao H, Zhao F, Zhang L, Gou J, Lu M, He Y, Lu H, Li Q.   +10 more
europepmc   +1 more source

Interactions of Antibody Drug Conjugate Anti‐Tubulin and Topoisomerase I Inhibitor Payloads with Radiotherapy to Potentiate Immunotherapy

Advanced Science, EarlyView.
Antibody drug conjugates deliver their cytotoxic anti‐tubulin or topoisomerase I inhibitor payloads to tumors through cancer cell receptor targeting. The released drug payloads induce cellular changes that interact with radiotherapy resulting in radiosensitization that improves cancer cell kill and stimulates anti‐tumor immune responses.
Jacqueline Lesperance, Bryan S. Yung, Michael M. Allevato, Marcus M Cheng, Maria F. Camargo, Robert Saddawi‐Konefka, Kanika Dhawan, Ashwyn K. Sharma, Mahsa Mortaja, Sophie Bice, Daniel J. Scanderbeg, Diego Alvarado, Jyoti Mayadev, Ramez N. Eskander, Stephen R. Adams, Pippa F. Cosper, J. Silvio Gutkind, Sunil J. Advani   +17 more
wiley   +1 more source

Low-dose interleukin-2 induces clonal expansion of BACH2-repressed effector regulatory T cells following acute coronary syndrome. [PDF]

Nat Cardiovasc Res
Case AG, O'Brien JW, Lu Y, Charlier FTW, Zhao X, Weng Y, Masters L, Tuong ZK, Sriranjan R, Cheriyan J, Kemper C, Clatworthy MR, Mallat Z, Zhao TX.   +13 more
europepmc   +1 more source

B-108 Specific HIV integration sites are linked to clonal expansion and persistence of infected cells

, 2016
F. Maldarelli, Xiaolin Wu, Ling Su, F. Simonetti, D. Wells, W. Shao, J. Spindler, Andrea L. Ferris, J. Mellors, Mary F. Kearney, J. Coffin, S. Hughes   +11 more
semanticscholar   +1 more source