Results 91 to 100 of about 143,820 (254)

Disabling COMPASS Promoter Licensing Shifts HDAC‐Inhibited Gastric Cancer Toward Sustained Transcriptional Suppression During Recovery

Advanced Science, EarlyView.
Combined inhibition of the WDR5 WIN pocket and HDAC activity converts SAHA‐induced hyperacetylation into a promoter state with reduced WDR5–COMPASS association and H3K4me3. MYC/E2F‐linked nascent transcription and biosynthetic recovery are suppressed, while apoptosis and senescence‐like features increase, resulting in sustained growth inhibition in ...
Jintian Song, Hui Yu, Jianping Jiang, Zhihui Jiang, Zhongshi Hong, Xu Zhang, Luchuan Chen, Shenghong Wei, Yi Wang   +8 more
wiley   +1 more source

Determinants of mosaic chromosomal alteration fitness

Nature Communications
Clonal hematopoiesis (CH) is characterized by the acquisition of a somatic mutation in a hematopoietic stem cell that results in a clonal expansion. These driver mutations can be single nucleotide variants in cancer driver genes or larger structural ...
Yash Pershad, Taralynn Mack, Hannah Poisner, Yasminka A. Jakubek, Adrienne M. Stilp, Braxton D. Mitchell, Joshua P. Lewis, Eric Boerwinkle, Ruth J. F. Loos, Nathalie Chami, Zhe Wang, Kathleen Barnes, Nathan Pankratz, Myriam Fornage, Susan Redline, Bruce M. Psaty, Joshua C. Bis, Ali Shojaie, Edwin K. Silverman, Michael H. Cho, Jeong H. Yun, Dawn DeMeo, Daniel Levy, Andrew D. Johnson, Rasika A. Mathias, Margaret A. Taub, Donna Arnett, Kari E. North, Laura M. Raffield, April P. Carson, Margaret F. Doyle, Stephen S. Rich, Jerome I. Rotter, Xiuqing Guo, Nancy J. Cox, Dan M. Roden, Nora Franceschini, Pinkal Desai, Alex P. Reiner, Paul L. Auer, Paul A. Scheet, Siddhartha Jaiswal, Joshua S. Weinstock, Alexander G. Bick   +43 more
doaj   +1 more source

Uncovering the complexity of clonal hematopoiesis and blood count abnormalities [PDF]

Clonal hematopoiesis is increasingly recognized as a pre-stage of hematological malignancies and is characterized by the presence of a clonal subset of blood cells carrying a somatic gene mutation.
Kamphuis, Priscilla
core   +1 more source

Development of Versatile Nanoparticle System for Efficient Drug Delivery into Pulmonary Endothelium

Advanced Science, EarlyView.
Pediatric acute respiratory distress syndrome (PARDS) suppresses the FOXF1 transcription factor and disrupts lung development. This study shows that the FOXF1‐activating small‐molecule compound, TanFe[F], can be precisely delivered to lung endothelial cells using the innovative LEDD nanoparticle system.
Afzaal N. Mohammed, Zicheng Deng, Arnab Misra, Marcus Orzabal, Ananya Kondapally, Enhong Li, Jonathan Do, Ying‐Wei Lan, Fatemeh Kohram, Hunter Blackburn, Andreas Damianos, Tanya V. Kalin, Vladimir V. Kalinichenko   +12 more
wiley   +1 more source

Thioredoxin‐2 Alleviates Osteoporosis by Restraining FOXO3a Nuclear Translocation

Advanced Science, EarlyView.
Endothelial TRX2 preserves bone homeostasis by retaining FOXO3a at mitochondria and limiting TRAIL production. Loss of TRX2 or oxidative stress releases FOXO3a for nuclear translocation, increasing endothelial TRAIL secretion and driving osteoclast formation and bone loss.
Chi Zhan, Zhaocai Zhou, Yue Ding, Rong Lian, Xinyu Li, Xintong Zhang, Jie Cao, Zhonghui Tang, Zhengmei Lin, Zhi Song, Feng He   +10 more
wiley   +1 more source

DNMT3A and TET2 dominate clonal hematopoiesis and demonstrate benign phenotypes and different genetic predispositions

, 2017
Key Points Somatic mutations driving clonal hematopoiesis occur mainly in DNMT3A and TET2 and have no significant impact on hematological phenotypes. There is a familial predisposition to acquire TET2 mutation.
Manuel Buscarlet, Guylaine Lépine, Vincent Bourgoin, Lambert Busque, Yassamin Feroz Zada, Sylvie Provost, Natasha Szuber, Marie-Pierre Dubé, Amina Barhdadi, Luigina Mollica   +9 more
core   +1 more source

Mechanical Distraction Engages a Neuro‐Immune Program to Drive Regenerative Soft‐Tissue Healing in Ilizarov Bone Transport

Advanced Science, EarlyView.
Ilizarov bone transport accelerates healing of soft‐tissue wounds through unclear mechanisms. In a rat model, sustained mechanical distraction elicits calcitonin gene‐related peptide (CGRP)‐dominant sensory reinnervation, creating a niche that shifts immune cells from inflammatory to repair‐promoting states and speeds re‐epithelialization.
Yueliang Zhu, Jiayu Chen, Xuehuan Wen, Kaijia Tang, Ling Gao, Chenxing Wang, Yixuan Feng, Si‐He Qin, Tao Chen, Xiaohua Yu   +9 more
wiley   +1 more source

Tumor-Infiltrating Clonal Hematopoiesis [PDF]

BACKGROUND: Clonal hematopoiesis of indeterminate potential (CHIP) is an age-related condition associated with increased mortality among patients with cancer.
Pospori, Constandina, Joyce, Johanna A, Huerga Encabo, Hector, Scott, Rachel, Harris, Steve K, O'Sullivan, Jennifer, Rowan, Andrew, Barbè, Vittorio, Hoxha, Elena, Grey, William, Malanchi, Ilaria, Brierley, Charlotte K, Rane, Jayant K, Bailey, Chris, Bola, Supreet Kaur, Wack, Andreas, Zaccaria, Simone, Berger, Michael F, Downward, Julian, Slama, Ramy, Quezada, Sergio A, Bonnet, Dominique, Dijkstra, Krijn K, Hackshaw, Allan, Mead, Adam J, Magness, Alastair, Zaidi, Rija, Álvarez-Prado, Ángel F, Papaemmanuil, Elli, Lo Celso, Cristina, Rudin, Charles M, Swanton, Charles, Peggs, Karl S, Pearce, David R, Clark, Sally-Ann, Green, Mary, Iliakis, Chrysante S, Pich, Oriol, Grönroos, Eva, Zagorulya, Maria, Papazoglou, Despoina, Anastasiou, Panayiotis, Thol, Kerstin, Stonestrom, Aaron J, Bernard, Elsa, Enfield, Katey SS, Jamal-Hanjani, Mariam, Hynds, Robert E   +47 more
core   +3 more sources

Single-cell resolved clonal dynamics in human hematopoiesis and regeneration

SINGLE-CELL RESOLVED CLONAL DYNAMICS IN HUMAN HEMATOPOIESIS AND REGENERATION Single-cell resolved clonal dynamics in human hematopoiesis and regeneration / Nitsch, Lena (Rights reserved) (-
Nitsch, Lena
core  

Large Oncosomes Induce Pro‐Metastatic Stromal‐Myeloid Reprogramming

Advanced Science, EarlyView.
Large oncosomes systemically reprogram bone marrow mesenchymal stem cells through innate nucleic acid sensing, driving inflammatory and immunosuppressive remodeling that supports a metastasis‐permissive bone marrow environment, revealing a novel tumor‐host communication axis in cancer. ABSTRACT Bone metastasis can be facilitated by systemic remodeling,
Taylon Felipe Silva, Virginia Marcia Concato‐Lopes, Fatima Bedier, Lauren Newman, Diana Kitka, Jamelle Brown, Blandine Victor, Minhyung Kim, Tatyana Vagner, Catherine Grasso, Dmitriy Sheyn, Sungyong You, Michael R. Freeman, Fayyaz S. Sutterwala, Helen S. Goodridge, Caroline Jefferies, Paola de Candia, Jlenia Guarnerio, Dolores Di Vizio   +18 more
wiley   +1 more source