Results 81 to 90 of about 143,820 (254)

Expanding Genetic Code to Generate Human Brain Organoids with Both Vasculature and Microglia‐Like Cells

Advanced Science, EarlyView.
Using genetic code expansion, we engineered vascularized human cerebral organoids (vhCOs) with microglia‐like cells and blood‐brain barrier features. vhCOs recapitulate neurovascular interactions, regional identities, and neuronal subtypes resembling the fetal brain.
Haishuang Lin, Yaqing Wang, Hu Du, Yuxin Qin, Haoyu Zhang, Peng Wang, Lin Wei, Jianhua Qin   +7 more
wiley   +1 more source

Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis

, 2012
Aging is characterized by clonal expansion of myeloid-biased hematopoietic stem cells and by an increased risk of myeloid malignancies. Exome sequencing of 3 elderly females with clonal hematopoiesis demonstrated by X-inactivation analysis identified ...
Provost, Sylvie, Heguy, Adriana, Zineb Hamilou, Figueroa, Maria, Ross L Levine, Adriana Heguy, Vasanthakumar, Aparna, Busque, Lambert, Agnes Viale, Hamilou, Zineb, Maryam Hassimi, Hassimi, Maryam, Lambert Busque, Ari Melnick, Socci, Nicholas, Godley, Lucy A, Mason, Christopher E, Lucy A Godley, Juan Li, Abdel-Wahab, Omar, Gonen, Mithat, Parva K Bhatt, Bhatt, Parva K, Patel, Jay P, Omar Abdel-Wahab, Li, Juan, Mollica, Luigina, Jay P Patel, Luigina Mollica, Melnick, Ari, Maria E Figueroa, Cameron W Brennan, Sylvie Provost, Viale, Agnes, Brennan, Cameron, Aparna Vasanthakumar, Christopher E Mason, Nicholas Socci, Mithat Gonen, Levine, Ross L   +39 more
core   +1 more source

CHD8‐Dependent Chromatin Licensing Sustains Trophoblast Stem Cell Transcriptional Programs

Advanced Science, EarlyView.
In this study, Huang et al., identify chromatin remodeler CHD8 as an essential factor in TSC maintenance and placental development. CHD8‐dependent chromatin accessibility supports the occupancy of key trophoblast TFs and is coupled to KMT2A‐associated H3K4me3 deposition at TSC stem and cell cycle genes, providing a permissive chromatin environment for ...
Yuanyuan Huang, Zhenhua Hu, Jiali Liao, Lijun Huang, Jinyu Liu, Chen Tu, Yuchen Li, Lulu Xie, Shilei Bi, Xiaobo Fang, Jingsi Chen, Lili Du, Wei Sun, Haibin Wang, Shuang Zhang, Dunjin Chen, Zhaowei Tu   +16 more
wiley   +1 more source

Identification of Clonal Hematopoiesis Mutations in Solid Tumor Patients Undergoing Unpaired Next-Generation Sequencing Assays [PDF]

, 2018
Purpose: In this era of precision-based medicine, for optimal patient care, results reported from commercial next-generation sequencing (NGS) assays should adequately reflect the burden of somatic mutations in the tumor being sequenced.
Sean J. Yoder, Grilley-Olson, Juneko, Catherine C. Coombs, Grilley-Olson, J.E., Bolton, Kelly, Levine, R.L., Montgomery, Nathan, Levine, Ross, Ball, M., Zehir, A., Padron, E., Maria E. Balasis, Michele C. Hayward, Earp, H, Soper, J.T., Todd C. Knepper, William Y. Kim, Papaemmanuil, E., Gillis, Nancy, Elli Papaemmanuil, Parker, J.S., Berg, Jonathan, Yoder, Sean, Christine M. Walko, Richards, Kristy, Yoder, S.J., Knepper, Todd, Kim, W.Y., Mesa, T.E., Walko, Christine, Montgomery, N.D., Weiss, Jared, Nirali M. Patel, Knepper, T.C., Hayes, D, Balasis, M.E., Gillis, N.K., John T. Soper, Patel, N.M., Joel S. Parker, H. Shelton Earp, Balasis, Maria, Soper, John, Padron, Eric, Ross L. Levine, Ahmet Zehir, Tania E. Mesa, Coombs, Catherine, D. Neil Hayes, Bolton, K.L., Mesa, Tania, Tan, Xianming, Zehir, Ahmet, Jared Weiss, Juneko E. Grilley-Olson, Neil Hayes, D., Eric Padron, Markus Ball, Richards, K.L., Hayward, Michele, Weiss, J., Nathan D. Montgomery, Kristy L. Richards, Ball, Markus, Parker, Joel, Patel, Nirali, Papaemmanuil, Elli, Nancy K. Gillis, Xianming Tan, Walko, C.M., Shelton Earp, H., Kelly L. Bolton, Kim, William, Jonathan S. Berg, Hayward, M.C., Berg, J.S., Coombs, C.C., Tan, X.   +77 more
core   +1 more source

ERα–PADI4–CXCL8 Axis Drives MDSC‐Mediated Immune Evasion in Anaplastic Thyroid Carcinoma

Advanced Science, EarlyView.
MAPK‐driven ligand‐independent ERα activation drives PADI4 transcription and translation. This enzyme then modifies CXCL8 chemokines through citrullination, generating a potent chemoattractant gradient specifically for myeloid‐derived suppressor cells.
Dongdong Zhang, Ying Cai, Junbin Zhang, Jianyong Zhang, Ran Jing, Ming Cai   +5 more
wiley   +1 more source

A framework for the molecular identification of CHIP for clinical research

HGG Advances
Summary: Clonal hematopoiesis of indeterminate potential (CHIP) is associated with many diseases of aging. Large research initiatives are needed to develop clinical guidelines for the management of individuals with CHIP and their risk of disease. However,
Philip Harraka, Robert L. O’Reilly, Jared Burke, Paul Yeh, Kerryn Howlett, Kiarash Behrouzfar, Daniele Belluoccio, Amanda Rewse, Brigid M. Lynch, Kristen J. Bubb, Stephen J. Nicholls, Roger L. Milne, Melissa C. Southey   +12 more
doaj   +1 more source

Ilexoside K Ameliorates Atherosclerosis by Suppressing CD72hi Macrophages and Blocking CXCL12–CXCR4 Axis to Inhibit Endothelial Pyroptosis

Advanced Science, EarlyView.
CD72hi macrophages drive endothelial pyroptosis and accelerate atherosclerosis through CXCL12–CXCR4‐mediated immune–vascular crosstalk. Ilexoside K suppresses this pathogenic communication by modulating CXCR4‐dependent endothelial responses, reducing inflammation and plaque progression. These findings reveal a macrophage–endothelial regulatory axis and
Xingling He, Sijing Li, Jiahui Chen, Liyu Lin, Xinyu Li, Xiaojiao Zhang, Yihui Zhang, Xingling Chen, Jinjian Guo, Zhongqi Yang, Lu Lu, Shihao Ni   +11 more
wiley   +1 more source

Primitive hematopoietic stem cells shows a polyclonal pattern in myelodysplastic syndromes

Haematologica, 2004
BACKGROUND AND OBJECTIVES: Clonal hematopoiesis is the hallmark of myelodysplastic syndromes, but the role played by pluripotent stem cells and progenitor cells in these disorders remains unclear.
F Guidetti, S Grazioli, F Capelli, C Marini, M Gallicchio, D De Micheli, L Castello, PP Sainaghi, GP Fra, G Saglio, GC Avanzi   +10 more
doaj  

PBRM1 Deficiency in Microglia Leads to Excessive Neurogenesis and Autism‐Like Behaviors via the CCL5‐CCR1/5‐β‐catenin Signaling Axis

Advanced Science, EarlyView.
Microglial PBRM1 deficiency drives excessive hippocampal neurogenesis by enhancing CCL5–CCR1/5 signaling, leading to autism‐like behaviors. A pro‐inflammatory IL1α+/TNFα+ microglial subset is identified as a key cellular contributor to this process. PBRM1 represses Ccl5 expression at the transcriptional level.
Yang‐Yang Duan, Lin‐Fei Jiao, Pei‐Pei Liu, Chun‐Hui Duan, Xiao Li, Zi‐Han Zhang, Yue‐Qi Zhang, Xin‐Li Ouyang, Hong‐Zhen Du, Sha Liu, Yi Tang, Zhao‐Qian Teng, Chang‐Mei Liu   +12 more
wiley   +1 more source

Innate immune-inflammatory signaling milieu in myeloid leukemia and aging-associated clonal hematopoiesis pathologies

Frontiers in Immunology
Age-related accumulation of somatic mutations in hematopoietic stem and progenitor cells (HSPCs), causing clonal hematopoiesis (CH), often precedes the development of hematologic malignancies.
Satyaki Bhowmik, Satyaki Bhowmik, Anwesha Bose, Anwesha Bose, Amitava Sengupta, Amitava Sengupta, Amitava Sengupta   +6 more
doaj   +1 more source