Results 201 to 210 of about 41,259 (301)

Clonal hematopoiesis sees Twin Peaks [PDF]

Blood, 2020
openaire   +2 more sources

Leveraging paired germline and somatic analysis to improve the classification of DDX41 variants

British Journal of Haematology, EarlyView.
Summary Constitutional pathogenic variants in DDX41 predispose to myelodysplasia and acute myeloid leukaemia. Acquisition of subsequent somatic hits in the second allele is frequent, with notable recurrent variants at key hotspots. Sequencing of Deoxyribonucleic acid from blood/marrow of 239 patients with suspected/confirmed haematological malignancies
Andrew George, Elisabeth Rolf, Monika Domeradzka, Sara Ribeiro, Brittany Mills, April Hallett, Suzanne Macmahon, Paula Proszek, Ridwan Shaikh, Lina Yuan, Michael Hubank, Mikel Valganon Petrizan, Terri P. McVeigh, Jamshid S. Khorashad   +13 more
wiley   +1 more source

Metabolite-induced DNA damage drives stochastic stem cell loss and clonal hematopoiesis. [PDF]

Cell Stem Cell
Kamimae-Lanning AN, Brown JM, Günther M, Esau F, Russell H, Larcher L, Langevin F, Isobe T, Wilson NK, Dingler FA, Cordell RL, Wang M, Millington CL, Claudino N, Gogola E, Nicholls M, Körber V, Göttgens B, de Bruijn MFTR, Garaycoechea JI, Soulier J, Höfer T, Patel KJ.   +22 more
europepmc   +1 more source

Immune insights into AA [PDF]

, 2017
Risitano, Antonio Maria
core   +1 more source

Decoding immune‐driven erythroid failure in pure red cell aplasia

British Journal of Haematology, EarlyView.
Pure red cell aplasia (PRCA) is increasingly recognised as a T‐cell‐mediated bone marrow failure syndrome, yet its immunogenetic drivers remain poorly defined. In their paper, Yamashita et al. integrate human leucocyte antigen (HLA) typing, T‐cell receptor repertoire analysis and mutational profiling to reveal enriched HLA alleles, signal transducer ...
Federico Spataro, Vanessa Desantis, Antonio Giovanni Solimando   +2 more
wiley   +1 more source

Immunological features of acquired pure red cell aplasia: Specific human leucocyte antigen alleles, signal transducer and activator of transcription 3 mutations and a unique T‐cell receptor beta motif

British Journal of Haematology, EarlyView.
Summary T‐cell abnormalities have been implicated in the pathogenesis of acquired pure red cell aplasia (PRCA), particularly in its major subtypes such as idiopathic PRCA, thymoma‐associated PRCA and large granular lymphocytic leukaemia (LGLL)–associated PRCA, and the precise details remain unclear.
Naruaki Yamashita, Toru Kawakami, Shuji Matsuzawa, Shotaro Miyairi, Masae Maruyama, Fumihiro Kawakami, Shunsuke Kojima, Ryu Yanagisawa, Yumiko Higuchi, Hideki Makishima, Hideyuki Nakazawa, Fumihiro Ishida   +11 more
wiley   +1 more source

Clinical impact of clonal hematopoiesis on patients with solid tumors: a systematic review and meta-analysis. [PDF]

Front Oncol
Croitoru VM, Turcu-Stiolica A, Croitoru AE, Paul D, Iacob R, Tanase AD, Saftoiu A, Sandra I, Tanase C, Croitoru-Cazacu IM.   +9 more
europepmc   +1 more source

Deciphering the full spectrum of Castleman diseases based on a cohort of 700 patients in a western country

British Journal of Haematology, EarlyView.
The spectrum of Castleman diseases has expanded over the past three decades. The phenotype of the diseases varies not only among the three major types but also according to the patient ancestry. Summary Under the Castleman disease (CD) eponym, three distinct diseases sharing common pathological features have been described over time.
Eric Oksenhendler, Marion Malphettes, Véronique Meignin, David Boutboul, Lionel Galicier   +4 more
wiley   +1 more source

The association of thrombocytopenia with haematological malignancy

British Journal of Haematology, EarlyView.
This review article discusses the interplay of immune dysregulation, clonality, and immunosuppressive therapies in immune thrombocytopenia and how this links to the risk of misattribution versus the development of haematological malignancy. Unresolved questions and directions for future research are also discussed. Isolated thrombocytopenia is commonly
Abi Vijenthira, Henrik Frederiksen, Michelle Sholzberg   +2 more
wiley   +1 more source

Interleukin-18 Inhibition Aggravates Atherosclerosis in Jak2^V617F Clonal Hematopoiesis. [PDF]

JACC Basic Transl Sci
Tavallaie M, Hsu CC, Hardaway BD, Dou H, Fidler T, Kim E, Schiavone SE, Ngai D, Xiao T, Wang N, Westerterp M, Tall AR.   +11 more
europepmc   +1 more source