Results 211 to 220 of about 143,820 (254)

Causal association between clonal hematopoiesis indeterminate potential and cancer: a Mendelian randomization study. [PDF]

Exp Biol Med (Maywood)
Jin J, Pu Q, Wu C, Lei Y, Hu Y, Yang X, Huang J, Wu F, Xiao L, Yu L.   +9 more
europepmc   +1 more source

Long‐term NSAID efficacy in haematological and bone manifestation of Ghosal haematodiaphyseal dysplasia: An expanded cohort

British Journal of Haematology, EarlyView.
Jonathan Bordat, Felipe Suarez, Matthieu Jestin, Guillaume Bonnard, Joy Benadiba, Stephane Vanderbecken, Thierry Molina, Valérie Cormier‐Daire, Regis Peffault de Latour, Marie Passet, Jean Soulier, Mathilde Doyard, Lise Larcher, Veronique Meignin, Flore Sicre de Fontbrune   +14 more
wiley   +1 more source

Evolution of CAR‐T Therapy: Functional Engineering, Manufacturing Innovation, and Future In Vivo Strategies

Cancer Science, EarlyView.
CAR‐T therapy is evolving across four interconnected dimensions: functional engineering, manufacturing innovation, alternative cell sources, and in vivo CAR programming. Together, these advances address limitations in therapeutic efficacy, safety, manufacturing complexity, scalability, and accessibility, providing complementary paths toward the next ...
Yukimi Sakoda
wiley   +1 more source

Evolution of clonal hematopoiesis during cancer treatment and its impact on outcomes. [PDF]

J Clin Invest
Arabzadeh M, Tang YH, Colin-Leitzinger C, Marzban S, Walgenbach D, Morganti S, Mahaganapathy V, Harper E, Teng M, Kresovich JK, Washington I, Parsons HA, Garber JE, West J, Ganesan S, Khiabanian H, Gillis N.   +16 more
europepmc   +1 more source

Association between chronic kidney disease and the risk of myelodysplastic syndromes: A large claims database study in Japan

British Journal of Haematology, EarlyView.
Yuta Baba, Takehiko Sambe, Tetsuya Fukuda, Tatsunori Oguchi, Kenji Momo   +4 more
wiley   +1 more source

Challenges in Gene‐Directed Therapies for Rare Neurodevelopmental Disorders Using HNRNPU as an Exemplar

Clinical Genetics, EarlyView.
Beyond diagnosing rare neurodevelopmental disorders like HNRNPU‐RNDD, developing gene‐directed therapies requires overcoming complex hurdles, including spatial, developmental, and cell‐type constraints. Addressing these requires understanding the molecular effects of dosage and chromatin dynamics to deliver precise, effective treatments.
Daniel Aiyedun, Susan F. Rogers, Doaa M. Taha, Meena Balasubramanian   +3 more
wiley   +1 more source

A 3D Bioprinted Platform That Maintains the Functional Integrity of Primary AML Cells

Cell Proliferation, EarlyView.
This study presents a 3D bioprinted platform using gelatin‐hyaluronic acid hydrogels to enhance primary AML cell survival and proliferation while preserving stem‐like properties in vitro. By recapitulating in vivo‐like metabolic activity and drug resistance, this system offers a robust tool for preclinical drug screening and personalised therapy ...
Wanling Huang, Bo Deng, Nini Guo, Yiyi Ding, Zhangjingwen Xu, Yiwen Lu, Yue Ma, Qian Ren, Nan Wang, Pengyu Huang, Xiaotong Ma   +10 more
wiley   +1 more source

Lexicon for Clonal Hematopoiesis in Liquid Biopsy. [PDF]

Clin Transl Sci
Tell R, Zehir A, Anfora AT, Basu G, Beidelschies M, Compton C, Cristiano S, Godsey JH, Hu J, Johann DJ, Juntilla M, Kansal R, Lo C, Lopez Ramos D, Mahaganapathy V, Merriam D, Rolfo C, Russell H, Singh U, Stetson D, You M, Leiman LC.   +21 more
europepmc   +1 more source

Cytoreductive therapy reduces JAK2V617F+ blood velocity and adhesion to activated endothelium

British Journal of Haematology, EarlyView.
Angelica DaSilva, Taimur Ul Islam, Swati Menon, Julia Nguyen, Paul Krenik, Conglin Ruan, Xianghua Luo, David K. Wood, Joan D. Beckman   +8 more
wiley   +1 more source

Chromatin Remodeller BRD9 Orchestrates Odontoblastic Differentiation via Coordinating RUNX2‐KLF4

Cell Proliferation, EarlyView.
During odontoblast lineage commitment, the chromatin remodeller BRD9 acts as a critical epigenetic coordinator, orchestrating the chromatin landscape to facilitate synergistic binding of key transcription factors RUNX2 and KLF4 to target loci for odontogenesis.
Wenrui Zeng, Yuxiu Lin, Yongyan Gao, Delan Huang, Yuanyuan Li, Honglei Ruan, Guohua Yuan, Huan Liu, Zhi Chen   +8 more
wiley   +1 more source