Results 161 to 170 of about 173,423,441 (192)

Clonal Hematopoiesis of Indeterminate Potential: A Multidisciplinary Challenge in Personalized Hematology

Journal of Personalized Medicine, 2020
Clonal hematopoiesis of indeterminate potential (CHIP) is a common age-related condition that represents a potential pre-phase of hematologic neoplasm. Next-generation sequencing (NGS) is used to detect and monitor clonal hematopoiesis, and the spectrum ...
Peter Valent, Georg Greiner, Gregor Hoermann   +2 more
exaly   +2 more sources

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Premalignant Clonal Hematopoiesis (Clonal Hematopoiesis of Indeterminate Potential and Clonal Cytopenia of Undetermined Significance)

Clinics in Laboratory Medicine, 2023
Premalignant clonal hematopoiesis is the presence of somatic alterations in the blood of otherwise healthy individuals. Although the condition is not considered as a cancer, it carries an increased risk of developing a hematologic malignancy, particularly in those with large neoplastic clones, multiple pathogenic mutations, and high-risk mutations.
Mark D Ewalt
exaly   +3 more sources

Clonal hematopoiesis of indeterminate potential in persons with HIV

AIDS, 2023
Background: Clonal hematopoiesis of indeterminate potential (CHIP) has been associated with older age, inflammation and with risk of coronary artery disease (CAD). We aimed to characterize the burden of CHIP, and to explore the association between CHIP, inflammatory markers, and CAD in older persons with HIV (PWH).
Knudsen, Andreas D., Eskelund, Christian Winther, Benfield, Thomas, Zhao, Yanan, Gelpi, Marco, Køber, Lars, Trøseid, Marius, Kofoed, Klaus F., Ostrowski, Sisse R., Reilly, Cavan, Borges, Álvaro H., Grønbæk, Kirsten, Nielsen, Susanne D.   +12 more
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Clonal hematopoiesis of indeterminate potential and cardiovascular disease

Translational Research, 2023
Age is the most important risk factor for cardiovascular disease and appears to be more than a marker of cumulative exposure to other risk factors such as dyslipidemia and hypertension. With aging, genetic mutations occur that are not present in our germline DNA, observed as somatic mosaicism.
Seyedmohammad, Saadatagah, Christie M, Ballantyne   +1 more
openaire   +2 more sources

Clonal hematopoiesis of indeterminate potential: implications for the cardiologists

Journal of Cardiovascular Medicine, 2023
Myeloproliferative neoplasms, including polycythemia vera, essential thrombocythemia, and myelofibrosis, are characterized by somatic gene mutations in bone marrow stem cells, which trigger an inflammatory response influencing the development of associated cardiovascular complications.
Sciatti E., D'Elia E., Gori M., Grosu A., Balestrieri G., Senni M., Barbui T., Gavazzi A.   +7 more
openaire   +2 more sources

Putative Mechanisms Underlying Cardiovascular Disease Associated with Clonal Hematopoiesis of Indeterminate Potential

Stem Cell Reports, 2020
Characterized by the expansion of somatic mutations in the hematopoietic lineages of aging individuals, clonal hematopoiesis of indeterminate potential (CHIP) is a common condition that increases the risk of developing hematological malignancies and ...
Reuben Kapur, Sarah S Burns
exaly   +2 more sources

Interplay between Clonal Hematopoiesis of Indeterminate Potential and Metabolism

Trends in Endocrinology and Metabolism, 2020
Clonal hematopoiesis of indeterminate potential (CHIP), defined as a clone of hematopoietic cells consisting of a single acquired mutation during a lifetime, has recently been discovered to be a major risk factor for atherosclerotic cardiovascular disease (CVD). As such, this phenomenon has sparked interest into the role that these single mutations may
Andrew Murphy, Laurent Yvan-Charvet, Man K S Lee   +2 more
exaly   +3 more sources

Clonal hematopoiesis of indeterminate potential and cardiovascular disease: Pathogenesis, clinical presentation, and future directions

Progress in Cardiovascular Diseases
Clonal hematopoiesis of indeterminate potential (CHIP) is a well-studied phenomenon in hematologic malignancies. With advancements in gene sampling and analysis and the use of large cohort studies, CHIP has recently been linked to cardiovascular disease (
Job A J Verdonschot, Chayakrit Krittanawong   +1 more
exaly   +2 more sources

Clonal Hematopoiesis of Indeterminate Potential

JAMA Cardiology
This JAMA Cardiology Patient Page describes clonal hematopoiesis of indeterminate potential (CHIP).
Peter, Libby, Ohad, Oren, Aeron M, Small
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Clonal hematopoiesis of indeterminate potential and risk of neurodegenerative diseases

Journal of Internal Medicine
AbstractBackgroundLittle is known regarding the association between clonal hematopoiesis of indeterminate potential (CHIP) and risk of neurodegenerative diseases.ObjectiveTo estimate the risk of neurodegenerative diseases among individuals with CHIP.MethodsWe conducted a community‐based cohort study based on UK Biobank and used Cox regression to ...
Karin E Smedby, Qianwei Liu, Huan Song
exaly   +3 more sources