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Clonal Hematopoiesis of Indeterminate Potential: Current Understanding and Future Directions
Current Oncology Reports, 2023This article summarizes the current knowledge about clonal hematopoiesis of indeterminate potential (CHIP), its association with cardiovascular disease (CVD), and other outcomes, pathogenesis, postulated mechanisms of various pathologies, current knowledge gaps, possible targets of intervention, and therapeutic implications.Recently, a common age ...
Inderpreet, Singh, Abhay, Singh
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Clonal hematopoiesis of indeterminate potential: recent developments and perspectives
Current Opinion in HematologyPurpose of review This review encompasses the recently published information on clonal hematopoiesis of indeterminate potential (CHIP) and discusses its future prospects. By announcing advances in the research of CHIP risk factors and related diseases, with the purpose of offering new insights to treat both hematologic and ...
Meiqi, Guo, Yuan, Li, Baobing, Zhao
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Clonal hematopoiesis of indeterminate potential and risk of immune thrombocytopenia
Journal of Internal MedicineAbstractBackgroundClonal hematopoiesis of indeterminate potential (CHIP) might contribute to the pathogenesis of immune thrombocytopenia (ITP) through immune dysfunction or impairment of megakaryopoiesis and platelet formation. However, little is known about subsequent risk of ITP among individuals with CHIP.ObjectiveTo investigate the risk of ITP ...
Qianwei Liu +6 more
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Clonal hematopoiesis of indeterminate potential in the companion dog
Leukemia, 2022Kimberley Sebastian +11 more
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Clonal hematopoiesis of indeterminate potential (CHIP): A potential contributor to lymphoma
Critical Reviews in Oncology/HematologyClonal hematopoiesis (CH) typically refers to the clonal expansion of hematopoietic stem cells (HSCs) due to genetic mutations, serving as the pathogenic basis for various diseases. Clonal hematopoiesis of indeterminate potential (CHIP) is a subtype of CH, emerging as a significant risk factor for myeloid malignancies and cardiovascular diseases, which
QingQing, Luo +3 more
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Incidence of Cytopenia in Clonal Hematopoiesis of Indeterminate Potential
BloodBackground: Clonal hematopoiesis of indeterminate potential (CHIP) is a risk factor for myeloid neoplasms (MN) and multiple other diseases of aging. CHIP with concurrent cytopenia is a five-fold stronger risk factor for these diseases.
James Brogan +6 more
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Clonal Hematopoiesis of Indeterminate Potential
Journal of Clinical Oncology, 2019Steffen, Boettcher, Benjamin L, Ebert
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Clonal hematopoiesis of indeterminate potential: contribution to disease and promising interventions
Molecular and Cellular BiochemistryIn clonal hematopoiesis of indeterminate potential (CHIP), subpopulations of blood cells carrying somatic mutations expand as the individual ages, and this expansion may elevate risk of blood cancers as well as cardiovascular disease. Individuals at higher risk of CHIP and therefore of CHIP-associated disease can be identified through mutational ...
Chongjie, Li +2 more
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Clonal Hematopoiesis of Indeterminate Potential Associated with Covert Cerebral Changes
Annals of NeurologyObjective Clonal hematopoiesis of indeterminate potential (CHIP) is an emerging risk factor for cardio‐cerebrovascular diseases. This study aimed to investigate CHIP's association with cerebrovascular or glymphatic changes in a community‐based population.
Yijuan Li +10 more
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