Results 171 to 180 of about 6,041 (204)

Premalignant Clonal Hematopoiesis (Clonal Hematopoiesis of Indeterminate Potential and Clonal Cytopenia of Undetermined Significance)

Clinics in Laboratory Medicine, 2023
Premalignant clonal hematopoiesis is the presence of somatic alterations in the blood of otherwise healthy individuals. Although the condition is not considered as a cancer, it carries an increased risk of developing a hematologic malignancy, particularly in those with large neoplastic clones, multiple pathogenic mutations, and high-risk mutations.
Mark D Ewalt
exaly   +3 more sources

Clonal hematopoiesis of indeterminate potential and cardiovascular disease

Translational Research, 2023
Age is the most important risk factor for cardiovascular disease and appears to be more than a marker of cumulative exposure to other risk factors such as dyslipidemia and hypertension. With aging, genetic mutations occur that are not present in our germline DNA, observed as somatic mosaicism.
Seyedmohammad, Saadatagah, Christie M, Ballantyne   +1 more
openaire   +2 more sources

Clonal hematopoiesis of indeterminate potential in persons with HIV

AIDS, 2023
Background: Clonal hematopoiesis of indeterminate potential (CHIP) has been associated with older age, inflammation and with risk of coronary artery disease (CAD). We aimed to characterize the burden of CHIP, and to explore the association between CHIP, inflammatory markers, and CAD in older persons with HIV (PWH).
Knudsen, Andreas D., Eskelund, Christian Winther, Benfield, Thomas, Zhao, Yanan, Gelpi, Marco, Køber, Lars, Trøseid, Marius, Kofoed, Klaus F., Ostrowski, Sisse R., Reilly, Cavan, Borges, Álvaro H., Grønbæk, Kirsten, Nielsen, Susanne D.   +12 more
openaire   +3 more sources

Clonal hematopoiesis of indeterminate potential: implications for the cardiologists

Journal of Cardiovascular Medicine, 2023
Myeloproliferative neoplasms, including polycythemia vera, essential thrombocythemia, and myelofibrosis, are characterized by somatic gene mutations in bone marrow stem cells, which trigger an inflammatory response influencing the development of associated cardiovascular complications.
Sciatti E., D'Elia E., Gori M., Grosu A., Balestrieri G., Senni M., Barbui T., Gavazzi A.   +7 more
openaire   +2 more sources

Interplay between Clonal Hematopoiesis of Indeterminate Potential and Metabolism

Trends in Endocrinology and Metabolism, 2020
Clonal hematopoiesis of indeterminate potential (CHIP), defined as a clone of hematopoietic cells consisting of a single acquired mutation during a lifetime, has recently been discovered to be a major risk factor for atherosclerotic cardiovascular disease (CVD). As such, this phenomenon has sparked interest into the role that these single mutations may
Camilla Bertuzzo Veiga, Laurent Yvan-Charvet, Andrew J Murphy   +2 more
exaly   +3 more sources

Telomere Attrition and Clonal Hematopoiesis of Indeterminate Potential in Cardiovascular Disease [PDF]

International Journal of Molecular Sciences, 2021
Clinical evidence suggests that conventional cardiovascular disease (CVD) risk factors cannot explain all CVD incidences. Recent studies have shown that telomere attrition, clonal hematopoiesis of indeterminate potential (CHIP), and atherosclerosis (telomere–CHIP–atherosclerosis, TCA) evolve to play a crucial role in CVD.
Chao-Yung Wang, Yi-Chun Huang
exaly   +3 more sources

Clonal Hematopoiesis of Indeterminate Potential

JAMA Cardiology
This JAMA Cardiology Patient Page describes clonal hematopoiesis of indeterminate potential (CHIP).
Peter, Libby, Ohad, Oren, Aeron M, Small
openaire   +2 more sources

Clonal hematopoiesis of indeterminate potential and risk of neurodegenerative diseases

Journal of Internal Medicine
AbstractBackgroundLittle is known regarding the association between clonal hematopoiesis of indeterminate potential (CHIP) and risk of neurodegenerative diseases.ObjectiveTo estimate the risk of neurodegenerative diseases among individuals with CHIP.MethodsWe conducted a community‐based cohort study based on UK Biobank and used Cox regression to ...
Qianwei Liu, Karin E Smedby, Huan Song
exaly   +3 more sources

Clonal hematopoiesis of indeterminate potential and atrial fibrillation

Heart Rhythm
Atrial fibrillation (AF) is the most common sustained arrhythmia. Clonal hematopoiesis of indeterminate potential, characterized by the clonal expansion of hematopoietic stem cells owing to acquired mutations without hematologic malignancies, has emerged as a potential risk factor for AF. This narrative review summarizes the shared risk factors between
Jie Liu, Nan Zhang, Guangshuai Teng, Gary Tse, Jie Bai, Gregory Y.H. Lip, Tong Liu   +6 more
openaire   +3 more sources